In vitro release of cytotoxic nucleoside analogs from lactide-caprolactone and lactide-glycolide copolymers

• Autorzy: Kryczka T. , Bero M. , Kasperczyk J. , Dobrzynski P. , Marciniec B. , Popielarz-Brzezinska M. , Grieb P.
• Języki publikacji: EN

Abstrakty

EN

The aims of our study were to assess the release of cytotoxic nucleoside analogs 5-fluorouracil and 2-chloro-2-deoxyadenosine from different lactide-glycolide or lactide-caprolactone biodegradable copolymers and the effects of sterilization on this release. The polymers were sterilized either with ethylene oxide at 37°C, or with gamma radiation (15 kGy, 20 kGy, or 25 kGy). The kinetics of nucleoside release from the copolymers were measured over 50 days. Four copolymers exhibited relatively constant release of nucleosides in micromolar concentrations during the entire obser­vation period. Sterilization with either ethylene oxide or gamma radiation only slightly influenced nucleoside release. Further development of these copolymers as an intracerebral nucleoside delivery system for local treatment of brain tumors is indi­cated.

Słowa kluczowe

EN

primary malignant brain tumour; brain; treatment; sterilization; 2-chloro-2'-deoxyadenosine; cladribine; 5-fluorouracil; tumour; in vitro; biodegradable copolymer

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 1
• Opis fizyczny: p.205-210,fig.

Twórcy

autor

Kryczka T.

• Polish Academy of Sciences, Warsaw, Poland

autor

Bero M.

autor

Kasperczyk J.

autor

Dobrzynski P.

autor

Marciniec B.

autor

Popielarz-Brzezinska M.

autor

Grieb P.

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