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The study sought a correlation between the number of AgNOR granules and the degree of cervical intraepithelial neoplasia (CIN). Thirty-five sections (5 normal, 10 CIN1, 10 CIN2 and 10 CIN3) were subjected to retrospective analysis. The percentage of cells with 1, 2, 3, 4 and more AgNORs was calculated and the number of granules per 100 cells was counted. The number of cells containing single granules decreases. However, the number increases with CIN level when the cells contain 4 and more AgNORs. The number of granules per 100 cells also increases with the degree of CIN. It can be thus concluded that the number of cells with 4 and more AgNOR granules can serve as a CIN differentiation exponent.
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p.209-212,fig.,ref.
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autor
- Medical University, M.Curie-Sklodowskiej 24A, 15-276 Bialystok, Poland
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Bibliografia
- 1. Calore EE, Maeda MY, Cavaliere MJ, Pereira SM, Shih LW, Pereira GM, de Melo JR (1997) Study of organizer nucleolar regions by the argyrophil technique in cervical intraepithelial neoplasias. Minerva Ginecol, 49: 59–62.
- 2. Lahshmi S, Nair SA, Jayasree K, Jayaprakash PG, Rajalekshmy TN, Kannan S, Pillai R (1993) Argyrophilic nucleolar organizer regions (AgNORs) in inflammatory pre-malignant and malignant lesions of the uterine cervix. Cancer Lett, 71: 197–201.
- 3. Pelusi G, Tere D, Formelli G, Rinaldi AM, Derenzini M (1997) AgNOR protein quantity of cervical smears correlates with that of histological sections in cervical intraepithelial neoplasia. Eur J Histochem, 41: 105–110.
- 4. Ploton D, Menager M, Jeanneson P, Himber G, Adnet JJ (1986) Improvement in the staining and in the visualization of the argyrophilic proteins of the nucleolar organizer region at the optical level. Histochem J, 18: 5–14.
- 5. Rowlands DC (1988) Nucleolar organising regions in cervical intraepithelial neoplasia. J Clin Pathol, 41: 1200–1202.
- 6. Sakai YI, Sakai AT, Isotani S, Cavaliere MJ, de Almeida LV, Calore EE (2001) Morphometric evaluation of nucleolar organizer regions in cervical intraepithelial neoplasia. Pathol Res Pract, 197: 189–192.
- 7. Terlikowski S, Lenczewski A, Famulski W, Sulkowski S, Kulikowski M (2001) Expression of nucleolar organizer regions (NORs) in ovarian epithelial tumors. Folia Histochem Cytobiol, 39: 161–162.
- 8. Terlikowski S, Lenczewski A, Sulkowski S, Kulikowski M (1999) Nucleolar organizer regions in differentiated preneoplastic and neoplastic endometrial lesions. Gynecol Obstet Invest, 47: 205–209.
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Bibliografia
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bwmeta1.element.agro-article-1bdc755b-54b0-41ac-89a3-94f21e7c483c