Peroxynitrite mediated linoleic acid oxidation and tyrosine nitration in the presence of synthetic neuromelanins

• Autorzy: Stepien K. , Wilczok A. , Zajdel A. , Dzierzega-Lecznar A. , Wilczok T.
• Języki publikacji: EN

Abstrakty

EN

Peroxynitrite-mediated linoleic acid oxidation and tyrosine nitration were analysed in the presence of synthetic model neuromelanins: dopamine (DA) -melanin, cysteinyldopamine (CysDA) -melanin and various DA/CysDA copolymers. The presence of melanin significantly decreased the amount of 3-nitrotyrosine formed. This inhibitory effect depended on the type and concentration of melanin polymer. It was found that incorporation of CysDA-derived units into melanin attenuated its protective effect on tyrosine nitration induced by peroxynitrite. In the presence of bicarbonate, the melanins also inhibited 3-nitrotyrosine formation in a concentration dependent manner, although the extent of inhibition was lower than in the absence of bicarbonate. The tested melanins inhibited peroxynitrite-induced formation of linoleic acid hydroperoxides, both in the absence and in the presence of bicarbonate. In the presence of bicarbonate, among the oxidation products appeared 4-hydroxynonenal (HNE). CysDA-melanin inhibited the formation of HNE, while DA-melanin did not affect the aldehyde level. The results of the presented study suggest that neuromelanin can act as a natural scavenger of peroxynitrite.

Słowa kluczowe

EN

oxidation; linoleic acid; DA-melanin; CysDA-melanin; synthetic neuromelanin; neuromelanin; nitration; DA-CysDA-copolymer; tyrosine; peroxidation; 3-nitrotyrosine

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2000
• Tom: 47
• Numer: 4
• Opis fizyczny: p.931-940,fig.,ref.

Twórcy

autor

Stepien K.

• Medical University of Silesia, Narcyzow 1, 41-200 Sosnowiec, Poland

autor

Wilczok A.

autor

Zajdel A.

autor

Dzierzega-Lecznar A.

autor

Wilczok T.

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