The NTP phosphate donor in kinase reactions: Is ATP a monopolist?

• Autorzy: Shugar D.
• Języki publikacji: EN

Abstrakty

EN

This brief overview describes some of the properties of various cellular phospho­transferase systems, with particular emphasis on nucleoside 5'-triphosphate (NTP)- dependent protein kinases and nucleoside kinases, for which it is widely and impli­citly assumed that ATP is the intracellular phosphate donor. Numerous examples are presented, based on the in vitro properties of these enzymes, to show that ATP is not the only, or frequently not even the major, phosphate donor, and that this is probably reflected in vivo. It is pointed out that in vitro studies of donor and acceptor speci­ficities of kinases must take account of the intracellular concentrations of nucleoside 5-triphosphates, a problem also relevant to the design of nucleoside analogues as chemotherapeutic agents. Attention is also drawn to NTP analogues as substrates/ inhibitors of protein kinases, and to several examples of low-molecular mass non- peptide substrates of these enzymes.

Słowa kluczowe

EN

nucleoside kinase; phosphate donor; chemotherapeutic agent; inhibitor; phosphotransferase; protein kinase; kinase reaction

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 1
• Opis fizyczny: p.9-23,fig.

Twórcy

autor

Shugar D.

• Polish Academy of Sciences, A.Pawinskiego 5a, 02-106 Warsaw, Poland

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