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Warianty tytułu
Hepcidin - a hormone in iron metabolism in man and animals. Part I. The role of hepcidin in absorption of iron of digestive tract and iron transport
Języki publikacji
Abstrakty
Hepcydyna jest hormonem peptydowym, wyizolowanym początkowo z ludzkiej krwi i moczu, a następnie z wątroby. Poznano rolą hepcydyny w regulacji wchłaniania żelaza w przewodzie pokarmowy i jego uwalniania z makrofagów. Także rola żelaza w ekspresji hepcydyny zostala określona.
The main role of iron is its part in the haemoglobin composition where it stabilizes its level. However, iron also plays a very important role in immunological processes. Hepcidin is a peptid hormone. It was first isolated from human blood and urine and its release was attributed to the liver. The lack of hepcidin production was connected with the organism overloading with iron and its excess with anaemia caused by iron deficit. Hepcidin was identified as a regulator which communicates the state of iron reserve in the organism with intestine cells responsible for the absorption. It decreases the absorption of iron in the intestines and increases the secretion of iron to the reticuloendothelial system. Experiments on animals deprived of hepcidine and with its excess allow the understanding of the dependence of iron homeostasis and confirm the role of hepcidin as a hormone regulating the iron metabolism.
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Tom
Numer
Strony
1-6
Opis fizyczny
s.1-6,bibliogr.
Twórcy
autor
- Szkola Glowna Gospodarstwa Wiejskiego, ul.Ciszewskiego 8, 02-786 Warszawa
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autor
Bibliografia
Typ dokumentu
Bibliografia
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