Ganglioside GM1 reduces white matter damage in neonatal rats

• Autorzy: Rong X. , Zhou W. , Chen X.-W. , Tao L. , Tang J.
• Języki publikacji: EN

Abstrakty

EN

This study investigated the neuronal protective effect of monosialotetrahexosylganglioside (GM1) on the hypoxia-ischemia white matter damage (WMD) in neonatal rats. Brain hypoxia-ischemia was induced by bilateral carotid artery occlusion in 4-day-old neonatal rats. Bilateral carotid artery occlusion (BCAO) was performed in rats in WMD and GM1 groups, while in sham group; the rat bilateral carotid arteries were merely exposed without occlusion. Immunohistochemical staining was used to determine the expression of myelin basic protein (MBP), glial fibrillary acidic protein (GFAP), and P-amyloid precursor protein (P-APP). In addition, suspension test, slope test, and open-field test were carried out on day 26 after BCAO to determine the neurobehavioral function. The percentage of MBP-positive cells was decreased while P-APP-and GFAP- positive cells were increased in WMD group. After treated with GM1, the percentage of MBP-positive cells increased significantly than WMD rats at post-operation 72 h and day 7. GFAP-positive cells and P-APP-positive cells decreased significantly in WMD group at post-operation 72 h, day 7 and 26. The suspension test, slope test, and open-field test showed that neurobehavioral function was improved in ganglioside GM1 group compared with WMD group. Taken together, our findings suggested that ganglioside GM1 treatment reduces hypoxia-ischemia induced impairment of the neurobehavioral function in WMD in neonatal rats.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2013
• Tom: 73
• Numer: 3
• Opis fizyczny: p.379-386,fig.,ref.

Twórcy

autor

Rong X.

• Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China

autor

Zhou W.

• Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China

autor

Chen X.-W.

• Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China

autor

Tao L.

• Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China

autor

Tang J.

• Department of Neonatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, China

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