The effects of papaverine and melatonin on the biosynthesis of reduced glutathione in selected organs in mice

• Autorzy: Szaroma W. , Lach H. , Dziubek K.
• Języki publikacji: EN

Abstrakty

EN

Papaverine - (3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline, PAP) is a member of the benzylisoquinone subgroup of the opium alkaloids. It has been widely used for treating such diseases as pulmonary arterial embolism or renal and biliary colic. The aim of the research was to evaluate the influence of papaverine and melatonin on GSH metabolism in blood, brain, liver and kidney of mice. The distinct decrease in the GSH concentration was found after injection of papaverine. This decrease was reversed by earlier injection of melatonin. The obtained results suggest that the inhibiting effect of papaverine on the GSH level is connected with disturbances in energy mechanisms in cells, mainly inhibition of aerobic energy metabolism.

• Wydawca: -
• Czasopismo: Acta Biologica Cracoviensia. Series Zoologia
• Rocznik: 2012
• Tom: 54
• Opis fizyczny: p.59-64,fig.,ref.

Twórcy

autor

Szaroma W.

• Department of Animal Physiology and Toxicology, Institute of Biology, Pedagogical University of Krakow, Podbrzezie 3, 31-054 Krakow, Poland

autor

Lach H.

• Jozef Dietl Malopolska Higher School in Krakow, W.Pola 4, Krakow, Poland

autor

Dziubek K.

• Department of Animal Physiology and Toxicology, Institute of Biology, Pedagogical University of Krakow, Podbrzezie 3, 31-054 Krakow, Poland

Uwagi

PL

Rekord w opracowaniu