Ultrastructure of renal tubular epithelial cells of rat’s kidneys after administration of L-arginine

• Autorzy: Perdycz A. , Boratynski Z. , Siermontowski P. , Kaczerska D. , Lonc G.
• Języki publikacji: EN

Abstrakty

EN

Sixteen white Wistar female rats were divided into two equal groups. Experimental group received per os 40 mg/kg b.w. of L-arginine, even other day for 2 weeks and were decapitated after 3 weeks of the experiment. Control rats received in the same manner 2 ml of distilled water and were decapitated after 3 weeks of the experiment. The renal lesions observed under electron microscope were of focal character and concerned only the experimental group. The tubules with necrotic cells were observed among normal tubules or single normal epithelial cells of the tubular wall. The boundaries between epithelial cells of the tubule wall were blurred. The mitochondria indicated abnormal structure. Numerous hsosomes and peroxisomes with dark, homogenous content were observed. The rough endoplasmic reticulum had widened channels and was focally completely destroyed. The nucleus of damaged cells was most commonly located in one of the cell poles; its shape was changed and visibly smaller than the nuclei of normal cells. Condensation and peripherally located chromatin were noticed. The lesions observed were characteristic for apoptotic cells.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2013
• Tom: 57
• Numer: 1
• Opis fizyczny: p.113-117,fig.,ref.

Twórcy

autor

Perdycz A.

• Department of Histology and Embryology with Laboratory of Experimental Cytology, Medical University of Lublin, 20-080 Lublin, Poland

autor

Boratynski Z.

• Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences Lublin, 20-950 Lublin, Poland

autor

Siermontowski P.

• Department of Maritime and Hyperbaric Department, Military Institute of Medicine, 81-519 Gdynia, Poland

autor

Kaczerska D.

• Department of Clinical Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland

autor

Lonc G.

• Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences Lublin, 20-950 Lublin, Poland

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Identyfikatory

DOI

10.2478/bvip-2013-0021