Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

PL EN


Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2013 | 73 | Suppl.1 |
Tytuł artykułu

Dynamic regulation of mRNA translation in neurons by FMRP and microRNAs

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Long term synaptic plasticity underlying learning and memory is believed to require the reversible and dynamic regulation of local protein synthesis, which is dysregulated in fragile x syndrome, the most common form of inherited intellectual disability and autism. Fragile x syndrome is caused by the loss of the Fragile X Mental Retardation, FMRP, an mRNA binding protein involved in the regulation of local protein synthesis at synapses. We elucidated a cooperative role and dynamic interaction between the Fragile X Mental Retardation, FMRP, and microRNAs to repress translation at synapses, which can be rapidly de-repressed in response to activation of gp1 metabotropic glutamate receptors. One FMRP target mRNA of interest has been postsynaptic density-95, PSD-95, which is localized to dendrites and can be translated at synapses in response to activation of mGluRs. More recent work has revealed the role of other microRNAs to regulate FMRP target mRNA translation that appears important for control of neuronal excitability. We speculate that fragile x syndrome may result from synaptic protein imbalances due to dysregulation of microRNAmediated control that is important for control of neuronal development, excitability and plasticity.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
73
Numer
Opis fizyczny
p.21
Twórcy
  • Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
autor
  • Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
autor
  • Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
autor
  • Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
autor
  • Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
  • Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-97bfe895-d266-46b6-a1f4-62e7c4ef1fa4
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.