CDP-choline (citicoline) attenuates brain damage in a rat model of birth asphyxia

• Autorzy: Fiedorowicz M. , Makarewicz D. , Stanczak-Mrozek K. I. , Grieb P.
• Języki publikacji: EN

Abstrakty

EN

To estimate protective potential of citicoline in a model of birth asphyxia, the drug was given to 7-day old rats subjected to permanent unilateral carotid artery occlusion and exposed for 65 min to a hypoxic gas mixture. Daily citicoline doses of 100 or 300 mg/kg, or vehicle, were injected intraperitoneally for 7 consecutive days beginning immediately after the end of the ischemic-hypoxic insult, and brain damage was assessed by gross zorphology score and weight deficit two weeks after the insult. Caspase-3, α-fodrin, Bcl-2, and Hsp70 levels were assessed at 0, 1, and 24 h after the end of the hypoxic insult in another group of rat pups subjected to the same insult and given a single dose of 300 mg/kg of citicoline or the vehicle. Citicoline markedly reduced caspase-3 activation and Hsp70 expression 24 h after the insult, and dose-dependently attenuated brain damage. In the context of the well-known excellent safety profile of citicoline, these data suggest that clinical evaluation of the efficacy of the drug in human birth asphyxia may be warranted.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2008
• Tom: 68
• Numer: 3
• Opis fizyczny: p.389-397,fig.,ref.

Twórcy

autor

Fiedorowicz M.

• Department of Experimental Pharmacology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland

autor

Makarewicz D.

• Department of Neurochemistry, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland

autor

Stanczak-Mrozek K. I.

• Department of Experimental Pharmacology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland

autor

Grieb P.

• Department of Experimental Pharmacology, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland

Uwagi

PL

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