Heptoprotective role of Artemisia scoparia Waldst. and kit against CCl4-induced toxicity in rats

• Autorzy: Waris T.S. , Khan M.R. , Shah N.A. , Shuaib M. , Hussain F. , Ishaq M. , Kamal Z. , Zeb U. , Ali S. , Ahmed S. , Hussain F.
• Języki publikacji: EN

Abstrakty

EN

In this study, the methanol extract of Artemisia scoparia was evaluated for its protective potential against carbon tetrachloride (CCl₄)-induced hepatic toxicity. Seven groups of mature albino rats were used in the course of the experiment and each group was treated with specific doses of plant extract and CCl₄. Silymarin was used as a standard protective drug. The results of the experiment revealed that Artemisia scoparia plant extract was successful in fighting CCl₄ toxicity as it clearly reduced the elevated levels of liver serum markers (alkaline phosphatase and alkaline aminotransferase), lipid peroxidation, nitrite content, and H₂O₂ on one side while enhancing the levels of antioxidant enzymes (catalase, peroxidase, superoxide dismutase, glutathione-s-transferase, γ-Glutamyltranspeptidase, and glutathione reductase) and protein content. It also protected DNA from the damaging effects of CCl₄. The findings of this study demonstrate that Artemisia scoparia plant extract plays a significant role in preventing the hepatic damages instigated with CCl₄ and can be used as a protective agent against oxidative stress-associated disorders.

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 2018
• Tom: 27
• Numer: 3
• Opis fizyczny: p.1307-1314,fig.,ref.

Twórcy

autor

Waris T.S.

• Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

autor

Khan M.R.

• Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

autor

Shah N.A.

• Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan

autor

Shuaib M.

• School of Ecology and Environmental Science, Yunnan University, No. 2 North Cuihu Road, Kunming, Yunnan, 650091, P.R. China

autor

Hussain F.

• Yunnan institute of Microbiology, School of Life Science, Yunnan University, Kunming, 650091, P.R. China

autor

Ishaq M.

• School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, District Minhang Shanghai, China

autor

Kamal Z.

• School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, District Minhang Shanghai, China
• Shaheed Benazir Bhutto University, Sheringal, KP, Pakistan

autor

Zeb U.

• 7 Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xian 710069, P.R. China

autor

Ali S.

• Department of Botany, Bacha Khan University Charsadda, Pakistan

autor

Ahmed S.

• Key Laboratory of Molecular Epigenetics, Ministry of Education, School of Life Sciences, Northeast Normal University, Changchun, 130024, Jilin, P.R. China

autor

Hussain F.

• 1School of Resources, Environmental and Chemical Engineering Nanchang University, Nanchang Jiangxi, P.R. China

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Identyfikatory

DOI

10.15244/pjoes/74018