Nigrostriatal projecting neurons express GDNF receptor subunit RET in adult rats

• Autorzy: He S.-M. , Zhao Z.-W. , Zhao l. , Wang X.-L. , Jia D. , Hou F. , Gao G.-D.
• Języki publikacji: EN

Abstrakty

EN

Nigrostriatal neurons expressing RET protein, a receptor protein tyrosine kinase of glial cell line-derived neurotrophic factor (GDNF), were investigated in rats using retrograde neural tracing with horseradish peroxidase (HRP) combined with immunohistochemistry. HRP/RET double-labeled neurons were abundantly distributed in the substantia nigra pars compacta ipsilateral to the caudate-putamen stereotaxically injected with HRP. Almost all the HRP-labeled neurons in nigra exhibited RET-like immunoreactivity, which however constituted more than half of the RET-immunoreactive cells. Our results present morphological evidence that GDNF-RET interaction plays important roles in physiological processes of nigrostriatal neuronal circuits of mammals.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2008
• Tom: 68
• Numer: 3
• Opis fizyczny: p.347-353,fig.,ref.

Twórcy

autor

He S.-M.

• Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China

autor

Zhao Z.-W.

• Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China

autor

Zhao l.

• Institute of Medical Sciences, University of Aberdeen, Aberdeen, U.K.

autor

Wang X.-L.

• Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China

autor

Jia D.

• Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China

autor

Hou F.

• Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China

autor

Gao G.-D.

• Department of Neurosurgery, Institute for Functional Neurosurgery P.L.A, TangDu Hospital, Fourth Military Medical University, Xian, People's Republic of China

Uwagi

PL

Rekord w opracowaniu