Electrophysiological properties of functionally identified adult mouse motoneurons

• Autorzy: Manuel M.
• Języki publikacji: EN

Abstrakty

EN

A salient feature in Amyotrophic Lateral Sclerosis (ALS) is that the vulnerability of motoneurons depends on the physiological type of their motor unit. The most vulnerable motoneurons, and the first to degenerate, are the motoneurons of the largest motor units that innervate the fast-contracting and fatigable muscle fibers (FF type), followed by the motoneurons of intermediate motor unit size, which innervate the fast-contracting and fatigue-resistant muscle fibers (FR type). Finally, the motoneurons of the smallest motor units, which mainly innervate the slow contracting and fatigue-resistant fibers (S type) are the most resistant and the least affected at the end-stage of disease. However, not much is known about the physiology of motor units in mice, compared to other species (cats and rats in particular). I have spent the last few years studying the intrinsic properties of adult mouse motoneurons while recording simultaneously the force developed by their motor unit. We’ve already demonstrated that the unusual electrical properties of mouse motoneurons have a profound impact on the force recruitment of their motor units. In my talk, I will present recent efforts in characterizing the electrical and mechanical properties of type-identified mouse motoneurons and motor units, and their potential relevance for understanding the pathophysiological mechanisms of ALS.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2019
• Tom: 79
• Numer: Suppl.1
• Opis fizyczny: XXXV

Twórcy

autor

Manuel M.

• CNRS, SPPIN Saints‑Peres Paris Institute for the Neurosciences, Universite de Paris, Paris, France