Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline

• Autorzy: Furgala A. , Salat R. , Salat K.
• Języki publikacji: EN

Abstrakty

EN

Oxaliplatin is a third‑generation, platinum‑based antitumor drug used to treat colorectal cancer. Since its main adverse effect is neuropathic pain resulting from chemotherapy‑induced peripheral neuropathy (CIPN), this drug is used to study the neurobiology of CIPN in rodents and to search for analgesics that could attenuate neuropathic pain symptoms – cold and tactile allodynia that develop in most of the oxaliplatin‑treated subjects. In this research, testing across various temperatures, we assessed the cold reactivity threshold of albino Swiss mice treated with oxaliplatin. We also investigated if amitriptyline, a tricyclic antidepressant drug and a sodium channel inhibitor, could attenuate cold allodynia caused by this chemotherapeutic drug. Cold allodynia was induced using a single intraperitoneal dose of oxaliplatin. In the cold plate test while testing various temperatures the pain sensitivity threshold was assessed at different time-points after oxaliplatin (late‑phase allodynia). Antiallodynic activity of intraperitoneal amitriptyline was assessed for doses of 1, 2.5 and 10 mg/kg. A statistically significant decrease in latency time to pain reaction was detected for all temperatures applied, but the earliest response (i.e., 2 h post‑injection) was noted at 2.5°C. In all experimental groups early‑phase cold allodynia was fully developed 3 h after oxaliplatin injection and it was maintained until the end of the observation period (7 days). Early‑phase cold allodynia induced by oxaliplatin can be effectively attenuated by amitriptyline.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2018
• Tom: 78
• Numer: 4
• Opis fizyczny: p.315-321,fig.,ref.

Twórcy

autor

Furgala A.

• Chair of Pharmacodynamics, Department of Pharmacodynamics, Jagiellonian University, Medical College, Krakow, Poland

autor

Salat R.

• Faculty of Production Engineering, Warsaw University of Life Sciences, Warsaw, Poland

autor

Salat K.

• Chair of Pharmacodynamics, Department of Pharmacodynamics, Jagiellonian University, Medical College, Krakow, Poland

Bibliografia

• Berrocoso E, Mico JA, Vitton O, Ladure P, Newman‑Tancredi A, Depoortère R, Bardin L (2011) Evaluation of milnacipran, in comparison with amitrip‑ tyline, on cold and mechanical allodynia in a rat model of neuropathic pain. Eur J Pharmacol 655: 46–51.
• Czopek A, Sałat K, Byrtus H, Rychtyk J, Pawłowski  M, Siwek A, Soluch J, Mureddu V, Filipek B (2016) Antinociceptive activity of novel amide de‑ rivatives of imidazolidine‑2,4‑dione in a  mouse model of acute pain. Pharmacol Rep 68: 529–535.
• Ewertz M, Qvortrup C, Eckhoff L (2015) Chemotherapy‑induced peripheral neuropathy in patients treated with taxanes and platinum derivatives. Acta Oncol 54: 587–591.
• Finnerup NB, Otto M, McQuay HJ, Jensen TS, Sindrup SH (2005) Algorithm for neuropathic pain treatment: An evidence based proposal. Pain 118: 289–305.
• Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanpaa  M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore A, Raja SN, Rice AS, Rowbotham M, Sena E, Siddall P, Smith BH, Wallace  M (2015) Pharmacotherapy for neuropathic pain in adults: A systematic review and meta‑analysis. Lancet Neurol 14: 162–173.
• Gagnon B, Almahrezi A, Schreier G (2003) Methadone in the treatment of neuropathic pain. Pain Res Manag 8: 149–154.
• Gong SS, Li YX, Zhang MT, Du J, Ma PS, Yao WX, Zhou R, Niu Y, Sun T, Yu JQ (2016) Neuroprotective Effect of Matrine in Mouse Model of Vincris‑ tine‑Induced Neuropathic Pain. Neurochem Res 41: 3147–3159.
• Hache G, Guiard BP, Nguyen TH, Quesseveur G, Gardier AM, Peters D, Munro G, Coudoré F (2015) Antinociceptive activity of the new triple re‑ uptake inhibitor NS18283 in a mouse model of chemotherapy‑induced neuropathic pain. Eur J Pain 19: 322–333.
• Han Y, Smith MT (2013). Pathobiology of cancer chemotherapy‑induced peripheral neuropathy (CIPN). Front Pharmacol 4: 156.
• Horishita T, Yanagihara N, Ueno S, Okura D, Horishita R, Minami T, Ogata Y, Sudo Y, Uezono Y, Sata T, Kawasaki T (2017) Antidepressants inhibit Na(v)1.3, Na(v)1.7, and Na(v)1.8 neuronal voltage‑gated sodi‑ um channels more potently than Na(v)1.2 and Na(v)1.6 channels ex‑ pressed in Xenopus oocytes. Naunyn Schmiedebergs Arch Pharmacol 390: 1255–1270.
• Jensen TS, Finnerup NB (2014) Allodynia and hyperalgesia in neuropathic pain: Clinical manifestations and mechanisms. Lancet Neurol 13: 924–935.
• Kremer M, Salvat E, Muller A, Yalcin I, Barrot M (2016) Antidepressants and gabapentinoids in neuropathic pain: mechanistic insights. Neuroscience 338: 183–206.
• Manji H (2013) Drug‑induced neuropathies. Handb Clin Neurol 115: 729–742.
• Masocha  W, Parvathy SS (2016) Preventative and therapeutic effects of a  GABA transporter 1 inhibitor administered systemically in a  mouse model of paclitaxel‑induced neuropathic pain. PeerJ 4: e2798.
• Mika J, Osikowicz  M, Makuch  W, Przewlocka B (2007) Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain. Eur J Pharmacol 560: 142–149.
• Nakanishi  M, Nakae A, Kishida Y, Baba K, Sakashita N, Shibata  M, Yoshikawa  H, Hagihara K (2016) Go‑sha‑jinki‑Gan (GJG) ameliorates allodynia in chronic constriction injury‑model mice via suppression of TNF‑expression in the spinal cord. Mol Pain 12: 1–16.
• Parisi JR, Martins de Andrade AL, Torres Silva JR, Silva ML (2017) Antiallo‑ dynic effect of intrathecal resiniferatoxin on neuropathic pain model of chronic constriction injury. Acta Neurobiol Exp 77: 317–322.
• Parvathy SS, Masocha W (2015) Coadministration of indomethacin and mi‑ nocycline attenuates established paclitaxel‑induced neuropathic ther‑ mal hyperalgesia: Involvement of cannabinoid CB 1 receptors. Sci Rep 5: 10541.
• Petrioli R, Pascucci A, Francini E, Marsili S, Sciandivasci A, Tassi R, Civitelli S, Tanzini G, Lorenzi M, FranciniG (2008) Neurotoxicity of FOLFOX‑4 as ad‑ juvant treatment for patients with colon and gastric cancer: A random‑ ized study of two different schedules of oxaliplatin. Cancer Chemother Pharmacol 61: 105–111
• Pevida  M, Lastra A, Hidalgo A, Baamonde A, Menéndez  L (2013) Spinal CCL2 and microglial activation are involved in paclitaxel‑evoked cold hy‑ peralgesia. Brain Res Bull 95: 21–27.
• Sada H, Egashira N, Ushio S, Kawashiri T, Shirahama M, Oishi R (2012) Re‑ peated administration of amitriptyline reduces oxaliplatin‑induced me‑ chanical allodynia in rats. J Pharmacol Sci 118: 547–551.
• Sakurai M, Egashira N, Kawashiri T, Yano T, Ikesue H, Oishi R (2009) Ox‑ aliplatin‑induced neuropathy in the rat: involvement of oxalate in cold hyperalgesia but not mechanical allodynia. Pain 147: 165–174.
• Sałat K, Filipek B (2015) Antinociceptive activity of transient receptor poten‑ tial channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. J Zhejiang Univ Sci B 16: 167–178.
• Sambasevam Y, Omar Farouk AA, Tengku Mohamad TAS, Sulaiman MR, Bharatham BH, Perimal EK (2017) Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury‑induced neuropathic pain: Possible involvement of the opioid system. Eur J Phar‑ macol 796: 32–38.
• Sanna MD, Ghelardini C, Galeotti N (2017) Spinal astrocytic c‑Jun N‑termi‑ nal kinase (JNK) activation as counteracting mechanism to the amitrip‑ tyline analgesic efficacy in painful peripheral neuropathies. Eur J Phar‑ macol 798: 85–93.
• Sawynok J, Zinger C (2016) Topical amitriptyline and ketamine for post‑her‑ petic neuralgia and other forms of neuropathic pain. Expert Opin Phar‑ macother 17: 601–609.
• Smith EML, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T, Bressler LR, Fadul CE, Knox C, Le‑Lindqwister N Gilman PB, Shapiro CL, Alliance for Clin‑ ical Trials in Oncology (2013) Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy‑induced painful periph‑ eral neuropathy: a randomized clinical trial. JAMA 309: 1359–1367.
• Torrance N, Ferguson JA, Afolabi E, Bennett MI, Serpell MG, Dunn KM, Smith BH (2013) Neuropathic pain in the community: More under‑treat‑ ed than refractory? Pain 154: 690–699.
• Vilholm OJ, Christensen AA, Zedan AH, Itani M (2014) Drug‑induced periph‑ eral neuropathy. Basic Clin Pharmacol Toxicol 115: 185–192.
• Xiao WH, Zheng H, Bennett GJ (2012) Characterization of oxaliplatin‑in‑ duced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel. Neuroscience 203: 194–206.
• Zhao M, Isami K, Nakamura S, Shirakawa H, Nakagawa T, Kaneko S (2012) Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice. Mol Pain 8: 55.
• Zhao M, Nakamura S, Miyake T, So K, Shirakawa H, Tokuyama S, Narita M, Nakagawa T, Kaneko S (2014) Pharmacological characterization of stan‑ dard analgesics on oxaliplatin‑induced acute cold hypersensitivity in mice. J Pharmacol Sci 124: 514–517.

Identyfikatory

DOI

10.21307/ane‑2018‑030