Expression of cocaine- and amphetamine-egulated transcript in the pancreas of the European bison

• Autorzy: Mozel S. , Matysek M. , Zacharko-Siembida A. , Szalak R. , Krzysiak M. , Arciszewski M.B.
• Języki publikacji: EN

Abstrakty

EN

Cocaine- and amphetamine-regulated transcript (CART) is a recently discovered neuropeptide thought to mainly act in most laboratory mammals and humans as anorexigenic factor. The expression of CART in wild living animals is barely known. In the present study immunohistochemical stainings were applied to identify CART-immunoreactive (IR) structures in the pancreas of European bison. Antibodies against neuronal marker Hu C/D were used to visualize intrapancreatic neurons. The expression of CART was detected in approx. 75% of Hu C/D-IR intrapancreatic neurons which may thus also act as interneurons. Additionally, in most intrapancreatic ganglia single CART-IR non-varicose nerve fibers running between neurons were found. Pancreatic blood vessels as well as intralobular ducts were sparsely innervated with CART-IR nerve fibers. Moderately numerous CART-IR nerve terminals were found to innervate the pancreatic endocrine and exocrine tissue. None of islet endocrine cells showed the expression of CART. No presence of CART-IR neuronal elements were found in external connective tissue capsule and septa penetrating inside to the organ. Our study is the first to outline the presence of some differences in CART-ergic innervation pattern of the pancreas between domestic and wild mammals. The lack of CART-IR endocrine islet cells in the pancreas of European bison is an interesting finding, nevertheless its significance is largely unknown at the moment and needs to be further investigated.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2019
• Tom: 75
• Numer: 11
• Opis fizyczny: p.669=672,fig.,ref.

Twórcy

autor

Mozel S.

• Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland

autor

Matysek M.

• Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland

autor

Zacharko-Siembida A.

• Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland

autor

Szalak R.

• Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland

autor

Krzysiak M.

• Bialowieza National Park, Park Palacowy 11, 17-230 Bialowieza, Poland
• Department of Food Hygiene and Public Health Protection, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland

autor

Arciszewski M.B.

• Department of Animal Anatomy and Histology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 13, 20-950, Lublin, Poland

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Identyfikatory

DOI

10.21521/mw.6295