Considering the ticking network of the intergeniculate leaflet neurons of the rat-in vitro studies

• Autorzy: Paluch K. , Chrobok L. , Lewandowski M. H.
• Języki publikacji: EN

Abstrakty

EN

The intergeniculate leaflet (IGL) is a small part of the biological clock mechanism. The well known IGL function is the integration of photic and non-photic information and then such integrated message is delivered to the master biological clock – suprachiasmatic nuclei. IGL consists of two main neuronal populations: enkephalinergic (ENK) and neuropeptide Y (NPY) positive neurons. In both populations GABA is expressed. During our study using patch clamp technique we investigated how the two kinds of IGL non-photic inputs: orexin and serotonin, can modulate the functioning of this structure. Moreover, we checked how local neurotransmitter (GABA) can affect IGL neuronal network. We observed that both orexin and serotonin can mainly activate target IGL neurons. In case of GABA we observed both inhibition and depolarization. Our data indicates that various IGL neurons can differently respond to non-photic signals what probably leads to modulation of output information.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.334

Twórcy

autor

Paluch K.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland

autor

Chrobok L.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland

autor

Lewandowski M. H.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland