Spinal cord, reticular formation and cerebellum-there and back again

• Autorzy: Hammar I.
• Języki publikacji: EN

Abstrakty

EN

Information on the activity within spinal premotor circuitry is vital for the performance of correct movements. This feedback is provided by ascending tract neurons forwarding information to the cerebellum either directly (via spinocerebellar pathways) or indirectly (via the reticular formation) and used by the cerebellum to modulate descending motor commands, thereby shaping the final motor output. We investigated whether ascending tract neurons also inform the cerebellum about descending motor commands, relayed by corticospinal- and reticulospinal tract neurons or the mesencephalic locomotor region (MLR). In a series of in vivo experiments axons of descending tract neurons were stimulated within the pyramids, the medial longitudinal fasciculus and the MLR. Responses evoked in individual spinal neurons of different subpopulations of spinocerebellar tracts were recorded both extracellularly and intracellularly. Descending motor commands are monitored by a number of spinocerebellar tracts. Monosynaptic excitation evoked by descending tract neurons was found in ventral spinocerebellar tracts neurons while only polysynaptic actions were found in dorsal spinocerebellar tract neurons and neurons of the indirect spinocerebellar tract projecting via the lateral reticular nucleus. Specific subpopulations of spinocerebellar projections forward information concerning the degree of activity in spinal circuitry related to centrally initiated and voluntary motor commands as well as the local neuronal circuitry [1–3]. Information forwarded between neurons in the spinal cord, cerebellum and the reticular formation may thus serve not only to correct but also to predict and prevent motor errors. 1. Hammar et al. (2011) J Physiol 589: 653–665; 2. Jankowska et al. (2011) J Physiol 589: 5709–5725; 3. Hammar et al. (2013) Society for Neuroscience Annual Meeting, San Diego, USA

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S29

Twórcy

autor

Hammar I.

• Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden