Sulfochitosan inhibits P-selectin-mediated HL-60 leukocyte adhesion under flow conditions

• Autorzy: Huang J. , Wang R. , Liu X. , Zeng X. , Wei M.
• Języki publikacji: EN

Abstrakty

EN

Excessive trafficking of leukocytes can lead to serious tissue injury. Here, four regioselectively sulfated chitosans were assessed as inhibitors of HL-60 leukocyte binding to P-selectin, by investigating their effect on leukocyte adhesion to CHO cells expressing human P-selectin under static and flow conditions. The results show that the sulfochitosans exhibit inhibitory activity in this general order: heparin > N-sulfated/6-O-sulfated chitosan ≥ 3-O,6-O-sulfated chitosan > 6-O-sulfated chitosan ≫ N-sulfated chitosan. This suggests that the sulfation of the double site in chitosan is essential for efficient inhibition of P-selectin-mediated HL-60 leukocyte adhesion and that such sulfochitosans may have potential as therapeutic agents against inflammatory disease.

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2013
• Tom: 18
• Numer: 2
• Opis fizyczny: p.200-208,fig.,ref.

Twórcy

autor

Huang J.

• Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University, Changchun 130024, P.R.China

autor

Wang R.

autor

Liu X.

autor

Zeng X.

autor

Wei M.

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