The influence of salsolinol on dopaminergic system activity within the mediobasal hypothalamus of anestrous sheep: A model for studies on the salsolinol-dopamine relationship

• Autorzy: Misztal T. , Hasiec M. , Tomaszewska-Zaremba D. , Dobek E. , Fulop F. , Romanowicz K.
• Języki publikacji: EN

Abstrakty

EN

Salsolinol with its derivatives has been considered as a potential neurotoxin for the dopaminergic system in the human and rat brain. Investigating a sheep model for studies on the action of salsolinol within the central nervous system we examined whether this compound is able to affect the hypothalamic neuroendocrine dopaminergic (NEDA) system during its high seasonal activity, when sheep entered to anestrus under the long day conditions. Therefore, salsolinol was infused into the third ventricle of the brain in combination with the in vivo push-pull perfusion of the mediobasal hypothalamus/median eminence (MBH/ME). The effects of this drug on either perfusate noradrenaline (NA) or plasma prolactin concentration were also studied. The infusion of salsolinol resulted in rapid and permanent diminution in dopamine (DA) release into the extracellular spaces of the MBH/ME up to an undetectable level and in the 57% decrease in DA metabolite 3,4- dihydroxyphenylacetic acid concentration, compared to the control. This effect of salsolinol was accompanied by the significant enhancement of the pituitary prolactin release into circulation. The concentration of other DA metabolite, homovanillic acid, as well as NA in the MBH/ME was not affected. Thus, our results in the anestrous sheep underline the role played by salsolinol as a neuromodulator for the hypothalamic NEDA system and as a signal transmitter for the pituitary prolactin release. We suggest that the hypothalamic NEDA system of anestrous sheep during its high secretory activity may be set as a model for studies on the salsolinol-dopamine relationship.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: 3
• Opis fizyczny: p.305-312,fig.,ref.

Twórcy

autor

Misztal T.

• Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition PAS, Jablonna, Poland

autor

Hasiec M.

• Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition PAS, Jablonna, Poland

autor

Tomaszewska-Zaremba D.

• Department of Neuroendocrinology, The Kielanowski Institute of Animal Physiology and Nutrition PAS, Jablonna, Poland

autor

Dobek E.

• Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition PAS, Jablonna, Poland

autor

Fulop F.

• Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Szeged, Hungary

autor

Romanowicz K.

• Department of Endocrinology, The Kielanowski Institute of Animal Physiology and Nutrition PAS, Jablonna, Poland

Bibliografia

• Anderson ST, Barclay JL, Fanning KJ, Kusters DHL, Waters MJ, Curlewis JD (2006) Mechanisms underlying the diminished sensitivity to prolactin negative feedback dur­ing lactation: reduced STST5 signalling and up-regulation of cytokine-inducible SH2 domain-containing protein (CIS) expression in tuberoinfundibular dopaminergic neurons. Endocrinology 147: 1195-1202.
• Antkiewicz-Michaluk L, Romańska I, Papla I, Michaluk J, Bakalarz M, Vetulani J, Krygowska-Wajs A, Szczudlik A (2000) Neurochemical changes induced by acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline and salsolinol in dopaminergic structures of rat brain. Neuroscience 96: 59-64.
• Antkiewicz-Michaluk L (2002) Endogenous risk factors in Parkinson's disease: dopamine and tetrahydroisoquino- lines. Pol J Pharm 54: 567-572.
• Bodnar I, Mravec B, Kubovcakova L, Toth B, Fulop F, Fekete MI, Kvetnansky R, Nagy GM (2004) Stress- as well as suckling-induced prolactin release is blocked by a structural analogue of the putative hypophysiotrophic prolactinreleasingfactor, salsolinol. J Neuroendocrinol 16: 208-213.
• Gorski K, Romanowicz K, Herman A, Molik E, Gajewska A, Tomaszewska-Zaremba D, Misztal T (2010a) The pos­sible involvement of salsolinol and hypothalamic prolac- tin in the central regulatory processes in Ewes during lactation. Reprod Dom Anim 45: e54-e60.
• Gorski K, Romanowicz K, Molik E, Fulop F, Misztal T (2010b) Effects of salsolinol and its antagonistic ana­logue, 1-MeDIQ, on growth hormone release in nursing sheep. Acta Neurobiol Exp (Wars) 70: 20-27.
• Hashizume T, Shida R, Suzuki S, Nonaka S, Yonezawa C, Yamashita T, Kasuya E, Sutoh M, Olah M, Szekacs D, Nagy GM (2008a) Salsolinol is present in the bovine posterior pituitary gland and stimulates the release of prolactin both in vivo and in vitro in ruminants. Domest Anim Endocrinol 34: 146-152.
• Hashizume T, Shida R, Suzuki S, Kasuya E, Kuwayama H, Suzuki H, Olah M, Nagy GM (2008b) Interaction between salsolinol (SAL) and thyrotropin-releasing hormone (TRH) or dopamine (DA) on the secretion of prolactin in ruminants. Domest Anim Endocrinol 34: 327-332.
• Hashizume T, Sawada T, Yaegashi T, Saito H, Ahmed AE, Goto Y, Nakajima Y, Jin J, Kasuya E, Nagy GM (2010) Characteristics of prolactin-releasing response to sal- solinol in vivo in cattle. Domest Anim Endocrinol 39: 21-25.
• Homicsko KG, Kertesz I, Randai B, Toth BE, Toth G, Fulop F, Fekete MI, Nagy GM (2003) Binding site of salsolinol: its properties in different regions of the brain and the pituitary gland of the rat. Neurochem Internat 42: 19-26.
• Kochman H, Kochman K (1977) Purifications of ovine and bovine prolactins on DEAE cellulose chromatography and preparative polyacrylamide gel electrophoresis. Bull Acad Polon Sci 25: 67-70.
• Lorenc-Koci E, Antkiewicz-Michaluk L, Kaminska A, Lenda T, Zieba B, Wieronska J, Smialowska M, Schulze G, Rommelspacher H (2008) The acute and chronic administration of 1,2-dimethyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline on the function of the nigrostriatal dopaminergic system in rats. Neuroscience 156: 973­986.
• Maruyama W, Takahashi T, Minami M, Takahashi A, Dostert P, Nagatsu T, Naoi M (1993) Cytotoxicity of dopamine- derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines. Adv Neurol 60: 224-230.
• Misztal T, Romanowicz K, Barcikowski B (1997) Natural and melatonin-stimulated changes in the circadian rhythm of prolactin secretion in the ewe during seasonal anestrus. Neuroendocrinology 66: 360-367.
• Misztal T, Gorski K, Tomaszewska-Zaremba D, Molik E, Romanowicz K (2008) Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its rela­tion to suckling-induced prolactin and growth hormone 425 release. J Endocrinol 198: 83-89.
• Misztal T, Gorski K, Tomaszewska-Zaremba D, Fulop F, Romanowicz K (2010a) Effects of a structural analogue of salsolinol, 1-MeDIQ, on pituitary prolactin release and dopaminergic activity in the mediobasal hypothalamus in nursing sheep. Brain Res 1307: 72-77.
• Misztal T, Tomaszewska-Zaremba D, Gorski K, Romanowicz K (2010b) Opioid-salsolinol relationship in the control of prolactin release during lactation. Neuroscience 170: 1165-1171.
• Moser A, Scholz J, Nobbe F, Vieregge P, Bohme V, Bamberg H (1995) Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease. J Neurol Sci 131: 183-189.
• Mravec B (2006) Salsolinol, a derivate of dopamine, is a possible modulator of catecholaminergic transmission: a review of recent developments. Physiol Res 55: 353­364.
• Naoi M, Maruyama W, Dostert P, Kohda K, Kaiya T (1996) A novel enzyme enantio-selectively synthesizes (R)sal- solinol, a precursor of a dopaminergic neurotoxin, N-methyl-(R)salsolinol. Neurosci Lett 212: 183-186.
• Naoi M, Maruyama W, Dostert P, Hashizume Y (1997) N-methyl-(R)salsolinol as a dopaminergic neurotoxin: from an animal model to an early marker of Parkinson's disease. J Neural Transm Suppl 50: 89-105.
• Naoi M, Maruyama W, Akao Y, Yi H (2002) Dopamine- derived endogenous N-methyl-(R)-salsolinol: its role in Parkinson's disease. Neurotoxicol Teratol 24: 579­591.
• Patsenka A, Antkiewicz-Michaluk L (2004) Inhibition of rodent brain monoamine oxidase and tyrosine hydroxy­lase by endogenous compounds - 1,2,3,4-tetrahydro-iso- quinoline alkaloids. Pol J Pharmacol 56: 727-734.
• Randai B, Kandar Z, Somogyvari-Vigh A, Mergl Z, Olah M, Fulop F, Vecsernyes M, Nagy GM (2005) Salsolinol induces a decrease in cyclic AMP at the median eminence and an increase at the adenohypophysis in lactating rats. Brain Res Bull 65: 105-110.
• Skipor J, Thiery J-C (2008) The choroids plexus - cerebro- spinal fluid system: undervaluated pathway of neuroen­docrine signaling into the brain. Acta Neurobiol Exp (Wars) 68: 414-428.
• Szekacs D, Bodnar I, Mravec B, Kvetnansky R, Vizi ES, Nagy GM, Fekete MI (2007a) The peripheral noradrener- gic terminal as possible site of action of salsolinol as prolactoliberin. Neurochem Internat 50: 427-434.
• Szekacs D, Bodnar I, Vizi ES, Nagy GM, Fekete MI (2007b) The role of catecholamines in the prolactin release induced by salsolinol. Neurochem Internat 51: 319-322.
• Thiery JC (1991) Monoamine content of the stalk-median eminence and hypothalamus in adult female sheep as affected by daylength. J Neuroendocrinol 3: 407-411.
• Tomaszewska-Zaremba D, Mateusiak K, Przekop F (2002) The involvement of GABAA receptors in the control of GnRH and p-endorphin release, and catecholaminergic activity in the preoptic area in anestrous ewes. Exp Clin Endocrinol Diabetes 110: 336-342.
• Toth BE, Homicsko K, Randai B, Maruyama W, DeMaria JE, Vecsernyes M, Fekete MI, Fulop F, Naoi M, Freeman ME, Nagy GM (2001) Salsolinol is a putative endogenous neuro-intermediate lobe prolactin-releasing factor. J Neuroendocrinol 13: 1042-1050.
• Toth BE, Bodnar I, Homicsko K, Fulop F, Fekete MIK, Nagy GM (2002) Physiological role of salsolinol: its hypophysiotrophic function in the regulation of pitu­itary prolactin secretion. Neurotoxicol Teratol 24: 655-666.
• Traczyk W, Przekop F (1963) Methods of investigation of the function of the hypothalamus and hypophysis in chronic experiments in sheep. Acta Physiol Polon 14: 217-226.
• Vetulani J, Antkiewicz-Michaluk L, Nalepa I, Sansone M (2003) A possible physiological role for cerebral tetrahy- droisoquinolines. Neurotox Res 5: 147-155.
• Wanpen S, Govitrapong P, Shavali S, Sangchot P, Ebadi M (2004) Salsolinol, a dopamine-derived tetrahydroisoqui- noline, induces cell death by causing oxidative stress in dopaminergic SH-SY5Y cells, and the said effect is attenuated by metallothionein. Brain Res 1005: 67-76.
• Welento J, Szteyn S, Milart Z (1969) Observations on the stereotaxic configuration of the hypothalamus nuclei in the sheep. Anatom Anz 124: 1-27.
• Wolińska E, Polkowska J, Domański E (1977) The hypotha- lamic centers involved in the control of production and release of prolactin in sheep. J Endocrinol 73: 21-29.
• Zhu W, Wang D, Zheng J, An Y, Wang Q, Zhang W, Jin L, Gao H, Lin L (2008) Effect of (R)-salsolinol and N-methyl- (R)-salsolinol on the balance impairment between dop- amine and acetylcholine in rat brain: involvement in pathogenesis of Parkinson disease. Clin Chem 54: 705­712.

Uwagi

Rekord w opracowaniu