Charakterystyka nowego wirusa grypy typu D

• Autorzy: Markowska-Daniel I. , Mickiewicz M. , Witkowski L. , Kita J.

Warianty tytułu

EN

Characterization of a new influenza virus type D

• Języki publikacji: PL

Abstrakty

EN

Influenza is caused by viruses belonging to the Orthomyxoviridae family. Currently three types of influenza virus are known: A (Influenza A virus, IAV), B (IBV) and C (ICV). Despite the fact that all these viruses are derived from a common ancestor they differ from each other by the number of segments, the size and sequence of RNA segments, antigenicity, pathogenicity and the spectrum of natural reservoirs. In 2011, a new influenza virus was isolated in the USA from pigs manifesting influenza-like symptoms. The virus was the most closely related to ICV. It was able to replicate in vitro in different cell cultures and displayed much broader cell tropism than human ICV. Moreover, in contrast to ICV, it was able to replicate at 37°C. Electron microscopic studies demonstrated features characteristic of Orthomyxoviruses. Despite morphological and organizational similarities, the biological properties of the new virus, including biochemical activity, differ from that of other influenza viruses. Enzymatic assays revealed that the new virus had negligible neuraminidase but detectable O-acetyloesterase activity. Further studies evidenced that the new virus varied from ICV in receptor binding, despite its sharing a conserved array of functional domains in the viral RNA genome replication and viral entry machinery. Analysis conducted with the use of the model of crystal structure of the hemagglutinin-esterase fusion protein (HE) of the new virus and its receptor demonstrated that this protein was multifunctional. It catalyzes cellular receptor binding, receptor cleavage, as well as membrane fusion. Moreover, divergent receptor-binding sites than HE of ICV have been discovered in the new virus. These amino acid differences may alter the binding specificity and affinity of the HE protein to the receptor that in turn result in the observed differences in cellular tropism between the two viruses. It also possesses an open channel between the 230-helix and 270-loop in the receptor-binding site, which is a unique feature of this virus. This might explain why the new virus has a broad cell tropism. It is possible that the sequence variation in the fusion domain may influence the replication of this virus at a higher temperature when compared to ICV. Next-generation sequencing demonstrated that the genome of the new virus, similarly to ICV, had seven single-stranded negative-sense RNA segments coding 9 viral proteins. Deep RNA sequencing found aM1 protein expression strategy different from that of ICV. Studies aimed at evaluating of the evolutionary relationship of both viruses revealed that the new virus and ICV shared an approximately 69-72% mean pairwise identity in the PB1 gene, which is reported to be the most conserved influenza virus protein. Additionally, differences were detected at 5’ and 3’ends of noncoding regions, which are also highly conserved. They both may be responsible for the lack of in vitro reassortment between ICV of human origin and the new virus. In the study characterizing antigenic properties of the new virus, no cross-reactivity was observed using HI and AGID tests. This indicates the major differences in conserved proteins M1 and NP between both viruses. Summing up, despite the fact that new virus is the most closely related to human ICV, the number of important antigenic and genetic distinctions among them is the basis for suggesting that the International Committee of Virus Taxonomy classify it as a separate genus – D. There is no doubt that the discovery of a new influenza virus genus will have a great impact on influenza research and ecology.

Słowa kluczowe

PL

wirusologia; wirusy; wirus influenzy; nowe typy wirusa; wirus influenzy D; charakterystyka; taksonomia; wlasciwosci biologiczne; wlasciwosci antygenowe

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2016
• Tom: 72
• Numer: 09
• Opis fizyczny: s.531-535,bibliogr.

Twórcy

autor

Markowska-Daniel I.

• Samodzielna Pracownia Epidemiologii i Ekonomiki Weterynaryjnej, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, ul. Nowoursynowska 159c, 02-776 Warszawa

autor

Mickiewicz M.

• Samodzielna Pracownia Epidemiologii i Ekonomiki Weterynaryjnej, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, ul. Nowoursynowska 159c, 02-776 Warszawa

autor

Witkowski L.

• Samodzielna Pracownia Epidemiologii i Ekonomiki Weterynaryjnej, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, ul. Nowoursynowska 159c, 02-776 Warszawa

autor

Kita J.

• Samodzielna Pracownia Epidemiologii i Ekonomiki Weterynaryjnej, Wydział Medycyny Weterynaryjnej, Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, ul. Nowoursynowska 159c, 02-776 Warszawa

Bibliografia

• Antón A., Marcos M. A., Codoner F. M., de Molina P., Martinez A., Cardeñosa N., Godoy P., Torner N., Martínez M. J., Ramón S., Tudó G., Isanta R., Gonzalo V., Jiménez de Anta M. T., Pumarola T.: Influenza C virus surveillance during the first influenza A(H1N1)2009 pandemic wave in Catalonia, Spain. Diagn. Microbiol. Infect. Dis. 2011, 69, 419-427.
• Bodewes R., Morick D., de Mutsert G., Osinga N., Bestebroer T., van der Vliet S., Smits S. L., Kuiken T., Rimmelzwaan G. F., Fouchier R. A. M., Osterhaus A. D. M. E.: Recurring influenza B virus infections in seals. Emerg. Infect. Dis. 2013, 19, 511-512.
• Collin E. A., Sheng Z., Lang Y., Ma W., Hause B. M., Li F.: Cocirculation of two distinct genetic and antigenic lineages of proposed influenza D virus in cattle. J. Virol. 2015, 89, 1036-1042.
• Crawford P. C., Dubovi E. J., Castleman W. L., Stephenson I., Gibbs E. P. J., Chen L., Smith C., Hill R. C., Ferro P., Pompey J., Bright R. A., Medina M. J., Jonson C. M., Olsen C W., Cox N. J., Klimov A. I., Katz J. M., Donnis R. O.: Transmission of equine influenza virus to dog. Science 2005, 310, 482-485.
• Ferguson L., Eckard L., Epperson W. B., Long L. P., Smith D., Huston C., Genova S., Webby R., Wan X. F.: Influenza D virus infection in Mississippi beef cattle. Virol. 2015, 486, 28-34.
• Forrest H. L., Webster R. G.: Perspectives on influenza evolution and the role of research. Anim. Health Res. Rev. 2010, 11, 3-18.
• Gatherer D.: Tempo and mode in the molecular evolution of Influenza C. PLOS Currents Influenza. 2010, 7, doi: 10.1371/currents.RRN1199.
• Guo Y., Jin F., Wang P., Wang M., Zhu J.: Isolation of influenza C virus from pigs and experimental infection of pigs with influenza C virus. J. Gen. Virol. 1983, 64, 177-182.
• Hause B. M., Collin E. A., Liu R., Huang B., Sheng Z., Lu W., Wang D., Nelson E. A., Li F.: Characterization of a novel influenza virus in cattle and swine: proposal for a new genus in the Orthomyxoviridae family. mBio. 2014, 5, 1-10.
• Hause B. M., Ducatez M., Collin E. A., Ran Z., Liu R., Sheng Z., Armien A., Kaplan B., Chakravarty S., Hoppe A. D., Webby R. J., Simonson R. R., Li F.: Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses. PLOS Pathogens 2013, 9, 1-11.
• Hensley S. E., Das S. R., Bailey A. L., Schmidt L. M., Hickman H. D., Jayaraman A., Viswanathan K., Raman R., Sasisekharan R., Bennink J. R., Yewdell J. W.: Hemagglutinin receptor binding avidity drives influenza A virus antigenic drift. Science 2009, 326, 734-736.
• Keawcharoen J., Oraveerakul K., Kuiken T., Fouchier R. A. M., Amonsin A., Payungporn S., Noppornpanth S., Wattanodorn S., Theamboonlers A., Tantilertcharoen R., Pattanarangsan R., Arya N., Ratanakorn P., Osterhaus A. D. M. E., Poovorawan Y.: Avian Influenza H5N1 in tigers and leopards. Emerg. Infect. Dis. 2004, 10, 2189-2191.
• Kimura H., Abiko C., Peng G., Muraki Y., Sugawara K., Hongo S., Kitame F., Mizuta K., Numazaki Y., Suzuki H., Nakamura K.: Interspecies transmission of influenza C virus between humans and pigs. Virus Res. 1997, 48, 71-79.
• Manuguerra J. C., Hannoun C.: Natural infection of dogs by influenza C virus. Res. Virol. 1992, 143, 199-204.
• Matsuzaki Y., Abiko C., Mizuta K., Sugawara K., Takashita E., Muraki Y., Suzuki H., Mikawa M., Shimada S., Sato K., Kuzuya M., Takao S., Wakatsuki K., Itagaki T., Hongo S., Nishimura H.: A nationwide epidemic of influenza C virus infection in Japan in 2004. J. Clin. Microbiol. 2007, 45, 783-788.
• Mänz B., Schwemmle M., Brunotte L.: Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier. J. Virol. 2013, 87, 7200-7209.
• Muraki Y., Hongo S., Sugawara K., Kitame F., Nakamura K.: Evolution of the haemagglutynin-esteraze gene of influenza C virus. J. Gen. Virol. 1996, 77, 673-679.
• Palese P., Shaw M. L.: Orthomyxoviridae: the viruses and their replication, [w:] Lippincott W. & Wilkins (red.): Fields virology. Philadelphia, USA 2007, s. 1647-1689.
• Parrish C. R., Murcia P. R., Holmes E. C.: Influenza virus reservoirs and intermediate hosts: dogs, horses, and new possibilities for influenza virus exposure of humans. J. Virol. 2015, 89, 2990-2994.
• Reperant L. A., Rimmelzwaan G. F., Kuiken T.: Avian influenza viruses in mammals. Rev. sci. tech. Off. int. Epiz. 2009, 28, 137-159.
• Saira K., Lin X., DePasse J. V., Halpin R., Twaddle A., Stockwell T., Angus B., Cozzi-Lepri A., Delfino M., Dugan V., Dwyer D. E., Freiberg M., Horban A., Losso M., Lynfield R., Wentworth D. N., Holmes E. C., Davey R., Wentworth D. E., Ghedin E.: INSIGHT FLU002 Study Group, INSIGHT FLU003 Study Group.: Sequence analysis of in vivo defective interfering-like RNA of influenza A H1N1 pandemic virus. J. Virol. 2013, 87, 8064-8074.
• Sandt C. E. van de, Bodewes R., Rimmelzwaan G. F., de Vries R. D.: Influenza B viruses: not to be discounted. Future Microbiol. 2015, 10, 1447-1465.
• Sheng Z., Ran Z., Wang D., Hoppe A. D., Simonson R., Chakravarty S., Hause B. M., Li F.: Genomic and evolutionary characterization of a novel influenza-C-like virus from swine. Arch. Virol. 2014, 159, 249-255.
• Song H., Qi J., Khedri Z., Diaz S., Yu H., Chen X., Varki A., Shi Y., Gao G. F.: An open receptor-binding cavity of hemagglutinin-esterase-fusion glycoprotein from newly-identified influenza D virus: basis for its broad cell tropism. PLOS Pathog. 2016, 12, 1-24.
• Songserm T., Amonsin A., Jam-On R., Sae-Heng N., Meemak N., Pariyothorn N., Payungporn S., Theamboonlers A., Poovorawan Y.: Avian influenza H5N1 in naturally infected domestic cat. Emerg. Infect. Dis. 2006, 12, 681-683.
• Tong S., Zhu X., Li Y., Shi M., Zhang J., Bourgois M., Yang H., Chen X., Recuenco S., Gomez J., Chen L. M., Johnsos A., Tao Y., Dreyfus C., Yu W., McBride R., Carney P. J., Gilbert A. T., Chang J., Guo Z., Davis C. T., Paulson J. C., Stevens J., Rupprecht C. E., Holmes E. C., Wilson I. A., Donis R. O.: New world bats harbor diverse influenza A viruses. PloS Pathog. 2013, 9, 1-12.
• Webster R. G., Bean W. J., Gorman O. T., Chambers T. M., Kawaoka Y.: Evolution and ecology of influenza A viruses. Microbiol. Rev. 1992, 56, 152-179.
• Yuanji G., Desselberger U.: Genome analysis of influenza C viruses isolated in 1981/82 from pigs in China. J. Gen. Virol. 1984, 65, 1857-1872.
• Yuanji G., Fengen J., Ping W., Min W., Jiming Z.: Isolation of influenza C virus from pigs and experimental infection of pigs with influenza C virus. J. Gen. Virol. 1983, 64, 177-182.

Identyfikatory

DOI

10.21521/mw.5565