Association between the ACE I/D polymorphism and physical activity in Polish women

• Autorzy: Cieszczyk P. , Jastrzebski Z. , Zarebska A. , Sawczyn M. , Drobnik-Kozakiewicz J. , Leonska-Duniec A , Zmijewski P. , Murawska-Cialowicz E. , Petr M. , Contro V. , Proia P. , Zaremba A. , Szumilo P.
• Języki publikacji: EN

Abstrakty

EN

Angiotensin converting enzyme gene (ACE) is the most frequently investigated genetic marker in the context of genetic conditioning of athletic predispositions. However, the knowledge of ACE’s potential modifying effect on changes in selected body traits achieved through a training programme is still limited. Therefore, we have decided to check whether selected body mass, body composition variables, oxygen uptake parameters as well as strength/speed parameters observed in physically active participants will be modulated by the ACE I/D polymorphism. The genotype distribution was examined in a group of 201 young healthy women measured for chosen traits before and after the completion of a 12-week moderate-intensive aerobic training programme. Our results revealed the significant genotype × training interactions for VEmax and power of countermovement jump, whereas training improvements were demonstrated for almost all parameters. In addition, main effects of the ACE I/D genotype on TGL, HDL, glucose and 10 m run were observed. A significant increase in VEmax was demonstrated for II and DD genotypes, but not for ID heterozygotes. The greatest gain in power of countermovement jump was observed in II homozygotes, although DD and ID were associated with a significant increase as well. Our study indicated that the polymorphism was associated with changes in VEmax and power of countermovement jump in response to a 12-week aerobic training programme in Caucasian women. However, more experimental studies are needed to establish the ACE gene × physical activity interactions.

• Wydawca: -
• Czasopismo: Trends in Sport Sciences
• Rocznik: 2016
• Tom: 23
• Numer: 4
• Opis fizyczny: p.203-210,ref.

Twórcy

autor

Cieszczyk P.

• Functional and Structural Human Research Centre, University of Szczecin, Szczecin, Poland

autor

Jastrzebski Z.

• Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Gdansk, Poland

autor

Zarebska A.

• Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Gdansk, Poland

autor

Sawczyn M.

• Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Gdansk, Poland

autor

Drobnik-Kozakiewicz J.

• Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Gdansk, Poland

autor

Leonska-Duniec A

• Functional and Structural Human Research Centre, University of Szczecin, Szczecin, Poland
• Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, Gdansk, Poland

autor

Zmijewski P.

• Institute of Sport, Warsaw, Poland

autor

Murawska-Cialowicz E.

• Department of Physiology and Biochemistry, University School of Physical Education in Wroclaw, Wroclaw, Poland

autor

Petr M.

• Charles University in Prague, Prague, Czech Republic

autor

Contro V.

• Department of Psychological, Pedagogical and Educational Sciences, University of Palermo, Palermo, Italy

autor

Proia P.

• Department of Psychological, Pedagogical and Educational Sciences, University of Palermo, Palermo, Italy

autor

Zaremba A.

• West Pomeranian Technical University of Szczecin, Szczecin, Poland

autor

Szumilo P.

• Department of Sport, University of Szczecin, Szczecin, Poland

Bibliografia

• 1. Adhihetty PJ, et al. Plasticity of skeletal muscle mitochondria in response to contractile activity. Exp Physiol. 2003; 88(1): 99-107.
• 2. Massidda M, Scorcu M, Calò CM. New genetic model for predicting phenotype traits in sports. Int J Sports Physiol Perform. 2014; 9(3): 554-560.
• 3. Leońska-Duniec A. Genetic research in modern sport. Central Eur J Sport Sci Med. 2013; 3(3): 19-26.
• 4. Leońska-Duniec A, Ahmetov II, Zmijewski P. Genetic variants influencing effectiveness of exercise training programmes in obesity – an overview of human studies. Biol Sport. 2016; 33(3): 207-214.
• 5. Proia P, et al. PPARα gene variants as predicted performance-enhancing polymorphisms in professional Italian soccer players. Open Access J Sports Med. Dec. 2014; 8(5): 273-278. Available at: https://www.ncbi. nlm.nih.gov/pmc/articles/PMC4266416.
• 6. Massidda M, Corrias L, Scorcu M, Vona G, Calò MC. ACTN-3 and ACE genotypes in elite male Italian athletes. Anthropol Rev. 2012; 75(1): 51-59.
• 7. Jones A, Montgomery HE, Woods DR. Human performance: a role for the ACE genotype? Ex Sport Sci Rev. 2002: 30(4): 184-190.
• 8. Gordon SE, et al. ANG II is required for optimal overload-induced skeletal muscle hypertrophy. Am J Physiol Endocrinol Metabol. 2001; 280(1): E150-159.
• 9. Moreau ME, et al. The kallikrein-kinin system: current and future pharmacological targets. J Pharmacol Sci. 2005; 99(1): 6-38.
• 10. Rigat B, et al. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res. 1992; 20(6): 1433.
• 11. Villard E, Soubrier F. Molecular biology and genetics of the angiotensin-I-converting enzyme: potential implications in cardiovascular diseases. Cardiovasc Res. 1996; 32(6): 999-1007.
• 12. Rigat B, et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990; 86(4): 1343-1346.
• 13. Myerson S, et al. Human angiotensin I-converting enzyme gene and endurance performance. J Appl Physiol. 1999; 87(4): 1313-1316.
• 14. Woods DR, Humphries SE, Montgomery HE. The ACE I/D polymorphism and human physical performance. Trends Endocrinol Metabol: TEM. 2000; 11(10): 416-420.
• 15. Lehnert M, Stastny P, Sigmund M, Xaverova Z, Hubnerova B, Kostrzewa M. The effect of combined machine and body weight circuit training for women on muscle strength and body composition. J Physical Edu Sport. 2015; 15(3): 561-568.
• 16. Štastny P, Fiala M, Petr M. The differences between ice-hockey academic national team and first Czech icehockey league players in speed and strenght premises by anaerobic Wingate test. Studia Kinanthropologica. 2010a; 11(2): 94-101.
• 17. Štastný P, Fiala M, Petr M. Srovnání poměrného tělesného složení s rychlostně silovými předpoklady hráčů akademické reprezentace v ledním hokeji dle anaerobního Wingate testu. Česká Kinantropologie. 2010b; 14(2): 46-58.
• 18. Cięszczyk P, et al. The angiotensin converting enzyme gene I/D polymorphism in Polish rowers. Int J Sports Med. 2009; 5(1): 624-627.
• 19. Alvarez R, et al. Genetic variation in the renin-angiotensin system and athletic performance. Eur J Appl Physiol. 2000; 82(1-2); 117-120.
• 20. Montgomery HE, et al. Human gene for physical performance. Nature. 1998; 393(6682); 221-222.
• 21. Williams AG, et al. The ACE gene and muscle performance. Nature. 2000; 403(6770); 614.
• 22. Defoor J, et al. The CAREGENE study: ACE gene I/D polymorphism and effect of physical training on aerobic power in coronary artery disease. Heart (British Cardiac Society). 2006; 92(4): 527-528.
• 23. Gosker HR, Pennings H-J, Schols AMWJ. ACE gene polymorphism in COPD. Am J Resp Critical Med. 2004; 170(5): 572, author reply 572-573.
• 24. Cam S, et al. ACE I/D gene polymorphism and aerobic endurance development in response to training in a nonelite female cohort. J Sports Med Physical Fitness. 2007; 47(2): 234-238.
• 25. Rankinen T, et al. Angiotensin-converting enzyme ID polymorphism and fitness phenotype in the HERITAGE Family Study. J Appl Physiol. 2000; 88(3): 1029-1035.
• 26. Folland J, et al. Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload. Exp Physiol. 2000; 85(5): 575-579.
• 27. Giaccaglia V, et al. Interaction between angiotensin converting enzyme insertion/deletion genotype and exercise training on knee extensor strength in older individuals. Int J Sports Med. 2008; 29(1): 40-44.
• 28. Pescatello LS, et al. ACE ID genotype and the muscle strength and size response to unilateral resistance training. Med Sci Sports Ex. 2006; 38(6): 1074-1081.