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2016 | 50 |
Tytuł artykułu

Evaluation of ursolic acid as the main component isolated from Catharanthus roseus against hyperglycemia

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Ursolic acid with large amount (0.67% of dried plant weight) along with 7 compounds, namely as spatozoate (1), kaurenoic acid (2), ursonic acid (3), 3-hydroxy-11-ursen-28,13-olide (4), ursolic acid (5), vindoline (6) and mixture of β-sitosterol and stigmasterol were isolated from dichloromethane and ethyl acetate extracts which have shown anti-glucosidase activity of the whole plant of C.roseus. Some isolated compounds and their derivatives were also tested for anti-glucosidase and cytotoxicity.Ursolic acid was examined for hypoglycemic activity in alloxan-induced diabetic mice with dose of 200 and 300 mg/kg/day, respectively. The results have shown that the blood glucose level were reduced by 45.75% and 51.31% to compare with the control group. This study has confirmed that the main component of Vietnamese C. roseus has had significant anti-hyperglycemia activity.
Wydawca
-
Rocznik
Tom
50
Opis fizyczny
p.7-17,fig.,ref.
Twórcy
autor
  • Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
autor
  • Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
autor
  • Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
  • Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
autor
  • Institute of Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam
autor
  • Department of Genetic Engineering, Agricultural Genetics Institute, Tuliem, Hanoi, Vietnam
autor
  • Department of Development Technology, Graduate School for International Development and Cooperation (IDEC), Hiroshima University, Japan
autor
  • Department of Genetic Engineering, Agricultural Genetics Institute, Tuliem, Hanoi, Vietnam
Bibliografia
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  • [3] L.Almagro, F.P. Francisco, M.A. Pedreno. Indole Alkaloids from Catharanthus roseus: Bioproduction and their effect on human health. Molecules. 20 (2015) 2973-3000.
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  • [6] P.H. Ho. Flora of Vietnam. Ho Chi Minh City: Youth Publishing House, 2000, 512 p.
  • [7] W. Kang, Y. Song, X. Gu. α-glucosidase inhibitory in vitro and antidiabetic activity in vivo of Osmanthus fragrans. J Med Plant Res. 6 (2012) 2850-2856.
  • [8] Y.P. Keepers, P.E. Pizao, G.J. Peter, J.V. Ark-Otte, B. Winograd, H.M. Pinedo. Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing. Eur. J. Cancer. 27 (1991) 897-900.
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  • [12] A. Natarajian, K.S.Z. Ahmed, S. Sundaresan, A. Sivaraj, K. Devi, B.S. Kumar. Effect aqueous flower extract of Cathanranthus roseus on alloxan induced diabetes in male albino rats. Inter J Pharm Sci Drug Res. 4 (2012) 150-153.
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  • [17] M.J. Siddiqui, Z. Ismail, A.F.A. Aisha, A.M.S. Abdul Majid. Cytotoxicity activity of Catharanthus roseus crude extracts and pure compounds against human coorctal carcinoma cell line. Inter J Pharm. 5 (2010) 43-47.
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  • [20] D.D. Thien, N.T. Tam, D.G. Thien, N.T.H. Anh, T.V. Sung.Synthesis and cytotoxic activity of ursolic acid derivatives. Zeitschrift für Naturforschung B. 68b (2013) 201-206.
  • [21] S.H. Tiong, C.Y. Looi, A. Arya, W.F. Wong, H. Hazni, M.R. Mustafa, K. Awang. Vindogentianine, a hypoglycemic alkaloid from Catharenthus roseus (L.) G.Don (Apocynaceae). Fitoterapia. 102 (2015)182-188.
  • [22] R. Van der Heijden, D.I. Jacobs, W. Snoeijer, D. Hallard, R. Verpoorte. The Catharanthus alkaloids: Pharmacognosy and biotechnology. Curr Med Chem. 11 (2004)1241-1253.
  • [23] P.P. Wu, K. Zhang, Y.J. Lu, P. He, S.Q. Zhao. In vitro and in vivo evaluation of the antidiabetic activity of ursolic acid derivatives. Eur J Med Chem. 80 (2014) 502-508.
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  • DOI References
  • [2] F. Afrapoli-Moradi, B. Asghari, S. Saeidnia, Y. Ajani, M. Mirjai, M. Malmir, R.D. Bazaz, A. Hadjakhoondi, P. Salehi, M. Hamburger, N. Yassa. In vitro α-glucosidase inhibitory activity of phenolic constituents from aerial parts of Polygonum hyrcanicum. Daru J Pharm Sci. 20 (2012). 10.1186/2008-2231-20-37
  • [3] L. Almagro, F.P. Francisco, M.A. Pedreno. Indole Alkaloids from Catharanthus roseus: Bioproduction and their effect on human health. Molecules. 20 (2015) 2973-3000. 10.3390/molecules20022973
  • [7] W. Kang, Y. Song, X. Gu. α-glucosidase inhibitory in vitro and antidiabetic activity in vivo of Osmanthus fragrans. J Med Plant Res. 6 (2012) 2850-2856. 10.5897/jmpr11.1402
  • [8] Y.P. Keepers, P.E. Pizao, G.J. Peter, J.V. Ark-Otte, B. Winograd, H.M. Pinedo. Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing. Eur. J. Cancer. 27 (1991) 897-900. 10.1016/0277-5379(91)90142-z
  • [9] R.J. Marles, N.R. Farnsworth. Antidiabetic plants and their active constitutents. Phytomedicine. 2 (1995)137-189. 10.1016/s0944-7113(11)80059-0
  • [10] A. Monks, D. Scudiero, P. Skehan, R. Shoemaker, K. Paull, D. Vistica, C. Hose, J. Langley, P. Cronise, A. Vaigro-Wolff, M. Gray-Goodrich, H. Campbell, J. Mayo, M. Boyd. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst. 83 (1991). 10.1093/jnci/83.11.757
  • [14] S.C. Ohadoma, H.U. Michael. Effects of co-administration of methanol leaf extract of Catharanthus roseus on the hypoglycemic activity of metformin and glibenclamide in rats. Asian Pac J Trop Med. 4 (2014) 475-477. 10.1016/s1995-7645(11)60129-6
  • [15] M.M. Rahman, M.N. Hasan, A.K. Das, M.T. Hossain, R. Jahan, M.A. Khatun, M. Rahmatullah. Effect of Delonix regia leaf extract on glucose tolerance in glucose induced hyperglycemic mice. Afr Tradit Complement Altern Med. 8 (2011) 34-36. 10.4314/ajtcam.v8i1.60505
  • [17] M.J. Siddiqui, Z. Ismail, A.F.A. Aisha, A.M.S. Abdul Majid. Cytotoxicity activity of Catharanthus roseus crude extracts and pure compounds against human coorctal carcinoma cell line. Inter J Pharm. 5 (2010) 43-47. 10.3923/ijp.2010.43.47
  • [20] D.D. Thien, N.T. Tam, D.G. Thien, N.T.H. Anh, T.V. Sung. Synthesis and cytotoxic activity of ursolic acid derivatives. Zeitschrift für Naturforschung B. 68b (2013) 201-206. 10.5560/znb.2013-2261
  • [21] S.H. Tiong, C.Y. Looi, A. Arya, W.F. Wong, H. Hazni, M.R. Mustafa, K. Awang. Vindogentianine, a hypoglycemic alkaloid from Catharenthus roseus (L. ) G. Don (Apocynaceae). Fitoterapia. 102 (2015)182-188. 10.1016/j.fitote.2015.01.019
  • [23] P.P. Wu, K. Zhang, Y.J. Lu, P. He, S.Q. Zhao. In vitro and in vivo evaluation of the antidiabetic activity of ursolic acid derivatives. Eur J Med Chem. 80 (2014) 502-508. 10.1016/j.ejmech.2014.04.073
Typ dokumentu
Bibliografia
Identyfikator YADDA
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