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2018 | 25 | 1 |
Tytuł artykułu

Dietary nitrates - to consume or to restrict?

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
After years of concerns that nitrates present in the diet or water may cause cancer or birth defects, there are more and more reports inquiring that their consumption may, however, imply a number of health benefits. The impact of nitrates is related primarily to nitric oxide effects in individual cells and tissues. Double reduction, observed in NO₃ ⁻ → NO₂ ⁻ → NO metabolic pathway, provides an alternative way of nitric oxide production, especially in ischemic or hypoxic conditions, when its obtaining from L-arginine is limited. Studies have shown that nitrate-rich diet improves bacteriostatic activity and positively impacts the cardiovascular system by increasing peripheral circulation and lowering systemic blood pressure. The relationship between nitrate intake and improvement of gastric epithelial function, mitochondrial metabolism and exercise tolerance was also confirmed. Although results of recent studies seem optimistic it has to be considered that most of them were conducted in a very small research groups and not all gave unequivocal results. So, to reliably answer the title question one still have to wait for more comprehensive research projects’ results.
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Tom
25
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1
Opis fizyczny
p.5-12,fig.,ref.
Twórcy
  • Department of Tourism and Recreation, Adam Mickiewicz University in Poznan, Poznan, Poland
autor
  • Faculty of Food Science and Nutrition, Poznan University of Life Sciences, Poznan, Poland
Bibliografia
  • 1. Australian Institute of Sport. 2017. Retrieved July 21, 2017, from: http://www.ausport.gov.au/ais/nutrition/ supplements/groupa.
  • 2. Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, DiMenna FJ, Wilkerson DP, et al. Dietary nitrate supplementation reduces the O₂ cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol. 2009; 107: 1144-1155. DOI: 10.1152/japplphysiol.00722.2009.
  • 3. Benjamin N, O’Driscoll F, Dougall H, Duncan C, Smith L, Golden M, Mckenzie H. Stomach NO synthesis. Nature. 1994; 368(6471): 502. DOI: 10.1038/368502a0.
  • 4. Bescos R, Ferrer-Rocca V, Galilea PA, Roig A, Drobnic F, Sureda A, et al. Sodium Nitrate Supplementation Does Not Enhance Performance of Endurance Athletes. Med Sci Sport Exer. 2012; 44(12): 2400-2409. DOI: 10.1249/ MSS.0b013e3182687e5c.
  • 5. Bescos R, Rodriguez FA, Iglesias X, Ferrer MD, Iborra E, Pons A. Acute administration of inorganic nitrate reduces VO₂ peak in endurance athletes. Med Sci Sport Exer. 2011; 43: 1979-1986. DOI: 10.1249/MSS.0b013e318217d439.
  • 6. Björne HH, Petersson J, Phillipson M, Weitzberg E, Holm L, Lundberg JO. Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest. 2004; 113: 106-114.
  • 7. Bondonno CP, Liu AH, Croft KD, Ward NC, Yang X, Considine MJ, et al. Short-term effects of nitrate-rich green leafy vegetables on blood pressure and arterial stiffness in individuals with high-normal blood pressure. Free Radical Bio Med. 2014; 77: 353-362. DOI: 10.1016/j.freeradbiomed.2014.09.021.
  • 8. Brown GC, Borutaite V. Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. BBA-Bioenergetics. 2004; 1658(1-2): 44-49. DOI: 10.1016/j.bbabio.2004.03.016.
  • 9. Bryan NS, Alexander DD, Coughlin JR, Milkowski AL, Boffetta P. Ingested nitrate and nitrite and stomach cancer risk: An updated review. Food Chem Toxicol. 2012; 50: 3646-3665. DOI: 10.1016/j.fct.2012.07.062.
  • 10. Bryan NS, van Grinsven H. The role of nitrate in human health. Adv Agron. 2013; 119(3): 153-182. DOI: 10.1016/ B978-0-12-407247-3.00003-2.
  • 11. Ceranowicz P, Warzecha Z, Dembiński A, Thor P, Niemiec J, Konturek SJ. Wpływ endogennego tlenku azotu na żołądkowo-jelitową aktywność motoryczną przewodu pokarmowego oraz wzrost błony śluzowej żołądka u szczurów (Effect of endogenous nitric oxide on the gastro-intestinal motor activity and growth of the gastric mucosa in rats’ gastrointestinal tract). Gastroenterol Pol. 1998; 5(2): 115-120 (in Polish).
  • 12. Christensen PM, Nyberg M, Bangsbo J. Influence of nitrate supplementation on VO₂ kinetics and endurance of elite cyclists. Scand J Med Sci Sports. 2013; 23(1): e21-e31. DOI: 10.1111/sms.12005.
  • 13. Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004; 109(III): 27-32. DOI: 10.1161/01.CIR.0000131515.03336.f8.
  • 14. Duncan C, Dougall H, Jahnston P, Green S, Brogan R, Leifert C, et al. Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat Med. 1995; 1(6): 546-551.
  • 15. Duranski MR, Greer JJM, Dejam A, Jaganmohan S, Hogg N, Langston W, et al. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest. 2005; 115(5): 1232-1240. DOI: 10.1172/JCI22493.
  • 16. Dykhuizen RS, Frazer R, Duncan C, Smith CC, Golden M, Benjamin N, Leifert C. Antimicrobial effect of acidified nitrite on gut pathogens: Importance of dietary nitrate in host defense. Antimicrob Agents Chemother. 1996; 40(6): 1422-1425.
  • 17. Eich RF, Li T, Lemon DD, Doherty DH, Curry SR, Aitken JF, et al. Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry-US. 1996; 22: 6976-6983. DOI: 10.1021/bi960442g.
  • 18. Garay RP. Cellular mechanisms of smooth muscle contraction. Rev Mal Respir. 2000; 17: 531-533.
  • 19. Gautier C, van Faassen E, Mikula I, Martasek P, Slama-Schwok A. Endothelial nitric oxide synthase reduces nitrite anions to NO under anoxia. Biochem Bioph Res Co. 2006; 341(3): 816-821. DOI: 10.1016/j. bbrc.2006.01.031.
  • 20. Gee LC, Ahluwalia A. Dietary Nitrate Lowers Blood Pressure: Epidemiological, Pre-clinical Experimental and Clinical Trial Evidence. Curr Hypertens Rep. 2016; 18: 17. doi: 10.1007/s11906-015-0623-4.
  • 21. Gnaiger E, Lassnig B, Kuznetsov A, Rieger G, Margreiter R. Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase. J Exp Biol. 1998; 201: 1129-1139.
  • 22. Govoni M, Jansson EA, Weitzberg E, Lundberg JO. The increase in plasma nitrite after dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide. 2008; 19: 333-337. doi: 10.1016/j.niox. 2008.08.003.
  • 23. Hord NG. Dietary nitrates, nitrites, and cardiovascular disease. Curr Atheroscler Rep. 2011; 13(6): 484-492. DOI: 10.1007/s11883-011-0209-9.
  • 24. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. P Natl Acad Sci USA. 1987; 84(24): 9265-9269.
  • 25. Joint Food and Agricultural Organization/World Health Organization Expert Committee on Food Additives. Nitrate (and Potential Endogenous Formation of N-Nitroso Compounds). 2003; Geneva: World Health Organization. WHO Food Additive Series, No. 50.
  • 26. Jungersten L, Ambring A, Wall B, Wenmalm A. Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. J Appl Physiol. 1997; 82(3): 760-764.
  • 27. Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, et al. Inorganic nitrate supplementation lowers blood pressure in humans role for nitrite-derived NO. Hypertension. 2010; 56: 274-281. DOI: 10.1161/ HYPERTENSIONAHA.110.153536
  • 28. Kenjale AA, Ham KL, Stabler T, Robbins JL, Johnson JL, VanBruggen M, et al. Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. J Appl Physiol. 2011; 110: 1582-1591. DOI: 10.1152/japplphysiol.00071.2011.
  • 29. Kowalczyk E, Kopff A, Kopff M, Błaszczyk J, Fijałkowski P, Kowalski J. Metabolizm tlenku azotu (Nitric oxide metabolizm). Wiad Lekar. 2006; LIX11-12: 889-93 (in Polish).
  • 30. Lansley KE, Winyard PG, Fulford J, Vanhatalo A, Bailey SJ, Blackwell JR, et al. Dietary nitrate supplementation reduces the O₂ cost of walking and running: a placebocontrolled study. J Appl Physiol. 2010; 110: 591-600. DOI: 10.1152/japplphysiol.01070.2010.
  • 31. Lara J, Ashor AW, Oggioni C, Ahluwalia A, Mathers JC, Siervo M. Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and metaanalysis. Eur J Nutr. 2016; 55: 451-459. DOI: 10.1007/s00394-015-0872-7.
  • 32. Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 2011; 13: 149-159. DOI: 10.1016/j.cmet.2011.01.004.
  • 33. Larsen FJ, Schiffer TA, Ekblom B, Mattsson MP, Checa A, Wheelock CE, et al. Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans. Am J Clin Nutr. 2014; 99: e843-e850. DOI: 10.3945/ajcn.113.079491.
  • 34. Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radical Bio Med. 2010; 48: 342-347. doi: 10.1016/j. freeradbiomed.2009.11.006.
  • 35. Lundberg JO, Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radical Bio Med. 2004; 37: 395-400. DOI: 10.1016/j. freeradbiomed.2004.04.027.
  • 36. Lundberg JO, Weitzberg E. Biology of nitrogen oxides in the gastrointestinal tract. Gut. 2013; 62: 616-629. DOI: 10.1136/gutjnl-2011-301649.
  • 37. McKnight GM, Smith LM, Drummond RS, Duncan CW, Golden M, Benjamin N. Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans. Gut. 1997; 40: 211-214.
  • 38. Millar J. The nitric oxide/ascorbate cycle: How neurones may control their own oxygen supply. Med Hypotheses. 1995; 45(1): 21-26.
  • 39. Mowbray M, McLintock S, Weerakoon R, Lomatschinsky N, Jones S, Rossi AG, et al. Enzymeindependent NO stores in human skin: Quantification and influence of UV radiation. J Invest Dermatol. 2009; 129: 834-842. DOI: 10.1038/jid.2008.296.
  • 40. Nitrate in vegetables Scientific Opinion of the Panel on Contaminants in the Food chain. The EFSA Journal. 2008; 689: 1-79.
  • 41. Omar SA, Webb AJ, Lundberg JO, Weitzberg E. Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases. J Intern Med. 2016; 279: 315-336. DOI: 10.1111/joim.12441.
  • 42. Pawlak-Chaouch M, Boissiere J, Gamelin FX, Cuvelier G. Effect of dietary nitrate supplementation on metabolic rate during rest and exercise in human: A systematic review and a meta-analysis. Nitric Oxide 53. 2016: e65-e76. DOI: 10.1016/j.niox.2016.01.001
  • 43. Peacock O, Tjǿnna AE, James P, Wislǿff U, Welde B, Böhlke N, et al. Dietary nitrate does not enhance running performance in elite cross-country skiers. Med Sci Sport Exer. 2012; 44(11): 2213-2219. DOI: 10.1249/ MSS.0b013e3182640f48.
  • 44. Pereira C, Ferreira NR, Rocha BS, Barbosa RM, Laranjinha J. The redox interplay between nitrite and nitric oxide: From the gut to the brain. Redox Biology. 2013; 1: 276-284. DOI: 10.1016/j.redox. 2013.04.004.
  • 45. Petersson J, Phillipson M, Jansson EA, Patzak A, Lundberg JO, Holm L. Dietary nitrate increases gastric mucosal blood flow and mucosal defense. Am J Physiol Gastrointest Liver Physiol. 2007; 292: G718-G724. DOI: 10.1152/ajpgi.00435.2006.
  • 46. Pospieszna B, Wochna K, Jerszyński D, Gościnna K, Czapski J. Ergogenic effect of dietary nitrates in female swimmers. Trends Sport Sci. 2016; 1(23): 13-20.
  • 47. Presley TD, Morgan AS, Bechtold E, Clodfelter W, Dove RW, Jennings JM, et al. Acute effect of high nitrate diet on brain perfusion in older adults. Nitric Oxide-Biol Ch. 2011; 24(1): 34-42. DOI: 10.1016/j. niox.2010.10.002.
  • 48. Rassaf T, Feelish M, Kelm M. Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues. Free Radic Biol Med. 2004; 36(4): 413-422. DOI: 10.1016/j.freeradbiomed.2003.11.011.
  • 49. Rocha BS, Gago B, Barbosa RM, Laranjinha J. Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation. Toxicology. 2009; 265: 41-48. DOI: 10.1016/j.tox.2009.09.008.
  • 50. Rocha BS, Gago B, Barbosa RM, Lundberg JO, Mann GE, Radi R. Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: a novel interaction between dietary nitrate and gut proteins. Free Radic Biol Med. 2013; 58: 26-34. DOI: 10.1016/j. freeradbiomed.2012.12.017.
  • 51. Rożek S. Czynniki wpływające na akumulację azotanów w plonie warzyw (Factors influencing the nitrate accumulation in vegetables yield). Zesz Nauk, AR Kraków, ser. Sesja Naukowa, 2000; 71, 19-31 (in Polish).
  • 52. Shiotani A, Iguchi M, Inoue I, Magari H, Yanaoka K, Tamai H, et al. Association between gastric myoelectrical activity and intraluminal nitric oxide. Aliment Pharmacol Ther. 2002; 16(2): 44-51.
  • 53. Shiva S. Mitochondria as metabolizers and targets of nitrite. Nitric Oxide. 2010; 22(2): 64-74. DOI: 10.1016/j. niox.2009.09.002.
  • 54. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: A systematic review and metaanalysis. J Nutr. 2013; 143: 818-826. DOI: 10.3945/ jn.112.170233.
  • 55. Sindelar JJ, Milkowski AL. Human safety controversies surrounding nitrate and nitrite in the diet. Nitric Oxide. 2012; 26: 259-266. DOI: 10.1016/j.niox.2012.03.011.
  • 56. Sobko T, Marcus C, Govoni M, Kamiya S. Dietary nitrate in Japanese traditional foods lowers diastolic blood pressure in healthy volunteers. Nitric Oxide. 2010; 22: 136-140. DOI: 10.1016/j.niox.2009.10.007.
  • 57. Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, et al. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol-Reg I. 2010; 299(4): 1121-1131. DOI: 10.1152/ajpregu.00206.2010.
  • 58. Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008; 51(3): 784-790. DOI: 10.1161/ HYPERTENSIONAHA.107.103523.
  • 59. Weitzberg E, Lundberg JO. Nonenzymatic nitric oxide production in humans. Nitric Oxide-Biol Ch. 1998; 2: 1-7. DOI: 10.1006/niox.1997.0162.
  • 60. Wightman EL, Haskell-Ramsay CF, Thompson KG, Blackwell JR, Winyard PG, Forster J, et al. Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebocontrolled, crossover investigation. Physiol Behav. 2015; 149: 149-158. DOI: 10.1016/j.physbeh.2015.05.035.
  • 61. Wilkerson DP, Hayward GM, Bailey SJ, Vanhatalo A, Blackwell JR,Jones AM. Influence of acute dietary nitrate supplementation on 50 mile time trial performance in well-trained cyclists. Eur J Appl Physiol. 2012; 112(12): 4127-4134. DOI: 10.1007/s00421-012-2397-6.
  • 62. World Health Organization. Nitrate and nitrite in drinkingwater. Background document for development of WHO Guidelines for Drinking-water Quality. 2011. Retrieved July 21, 2016, from: http://www.who.int/water_ sanitation_health/dwq/chemicals/nitratenitrite2ndadd. pdf
  • 63. Wylie LJ, Kelly J, Bailey SJ, Blackwell JR, Skiba PF, Winyard PG, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol. 2013; 115: 325-336. DOI: 10.1152/ japplphysiol.00372.2013.
  • 64. Zgórska K, Grudzińska M. Rozmieszczenie azotanów (V) w różnych częściach wybranych warzyw i w bulwach ziemniaka (Nitrate location in different parts of selected vegetables and in potato tubers). Biul Nauk, UWM. 2009; 30: 103-109 (in Polish).
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