Canine renal amyloidosis: a case report

• Autorzy: Szczepankiewicz B. , Paslawska U. , Grzegory M. , Jonkisz P. , Borecka P. , Marzec M. , Brzozowska M. , Nowak M.
• Języki publikacji: EN

Abstrakty

EN

Amyloidosis is a disease caused by the deposition of amorphous extracellular protein, leading to impaired kidney function. Canine and feline amyloidosis is associated with the deposition of AA protein. The disease is hereditary and is related to breed but not sex. Predisposed breeds include the Shar Pei dog and Abyssinian cat. Proteinuria resulting in hypoalbuminemia due to changes in renal glomeruli is the first clinical sign. In addition, a decreased appetite, anorexia, vomiting, lethargy, polyuria and polydipsia may be observed. In order to diagnose the disease, serum amyloid A levels may be measured. However, a definitive diagnosis is made on the basis of an intravital renal biopsy and the presence of amyloid in the histopathological examination. The main goal of treatment is to reduce inflammation and proteinuria. If nephrotic syndrome occurs, the prognosis is guarded to poor, and the majority of patients do not survive one year. The definitive diagnosis is based on the post-mortem examination, in which the presence of amyloid deposits is confirmed in the kidney tissue. We present the case of a 7-year-old female Shar Pei diagnosed with kidney amyloidosis, on the basis of which we have developed a prevention scheme for clinical practice.

Słowa kluczowe

EN

animal disease; dog; kidney; renal amyloidosis; amyloidosis; proteinuria

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2018
• Tom: 74
• Numer: 05
• Opis fizyczny: p.320-323,fig.,ref.

Twórcy

autor

Szczepankiewicz B.

• Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Pl.Grunwaldzki 47, 50-375 Wroclaw, Poland

autor

Paslawska U.

• Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Pl.Grunwaldzki 47, 50-375 Wroclaw, Poland

autor

Grzegory M.

• Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Pl.Grunwaldzki 47, 50-375 Wroclaw, Poland

autor

Jonkisz P.

• Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Pl.Grunwaldzki 47, 50-375 Wroclaw, Poland

autor

Borecka P.

• Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50-375 Wroclaw, Poland

autor

Marzec M.

• Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50-375 Wroclaw, Poland

autor

Brzozowska M.

• Department and Clinic of Veterinary Surgery, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Pl. Grunwaldzki 51, 50-366 Wrocław

autor

Nowak M.

• Department of Pathology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50-375 Wroclaw, Poland

Bibliografia

• Bugbee A., Coleman A., Wang A., Woolcock A., Brown A.: Telmisartan of refractory proteinuria in dogs. J. Vet. Intern. Med. 2014, 28, 1871-1874.
• Ceron J., Eckersall P., Martinez-Subiela S.: Acute phaseprotein in dogs and cats: Current knowledge and future perspectives. Vet. Clin. Pathol. 2005, 34, 85-99.
• Cook A., Cowgill L.: Clinical and pathological features of protein-losing glomerular disease in the dog: a review of 137 cases (1985-1992). J. Am. Anim. Hosp. Assoc. 1996, 32, 313-322.
• DiBartola S., Benson M.: The pathogenesis of reactive systemic amyloidosis. J. Vet. Intern. Med. 1989, 3, 31-41.
• DiBartola S., Tarr M., Benson M.: Tissue distribution of amyloid deposits in Abyssinian cats with familial amyloidosis. J. Comp. Pathol. 1986, 96, 387-398.
• Dudley A., Thomason J., Fritz S., Grady J., Stokes J., Wills R., Pinchuk L., Mackin A., Lunsford K.: Cyclooxygenase expression and platelet function in healthy dogs receiving low-dose aspirin. J. Vet. Intern. Med. 2013, 27, 141-149.
• Jull B.: Zakrzepica płucna i amyloidoza kłębuszków nerkowych u psa. Weterynaria po Dyplomie 2000, 1, 66-67.
• Lees G., Brown S., Elliott J., Grauer G., Vaden S.: Assessment and management of proteinuria in dogs and cats: 2005 ACVIM forum consensus statement (small animal). J. Vet. Intern. Med. 2005, 19, 377-385.
• Littman M.: Protein-losing nephropathy in small animals. Vet. Clin. North. A. Small Anim. Pract. 2011, 41, 40-42.
• Paltrinieri S.: The feline acute phase reaction. Vet. J. 2008, 177, 26-35.
• Pressler B., Vaden S.: Managing renal amyloidosis in dogs and cats. Vet. Med. 2003, 98, 320-323.
• Sasaki K., Ma Z., Khatlani T., Okuda M., Inokuma M., Inishi T.: Evaluation of feline serum amyloid A (SAA) as an inflammatory marker. J. Vet. Med. Sci. 2003, 65, 545-548.
• Segev G., Cowgill L., Jessen S., Berkowitz A., Mohr A., Aroch I.: Renal Amyloidosis in Dogs: A Retrospective Study of 91 Cases with Comparison of the Disease between Shar-Pei and Non-Shar-Pei Dogs. Vet. Intern. Med. 2012, 26, 259-268.
• Shtrasburg S., Gal R., Gruys E., Perl S., Martin B., Kaplan B., Koren R., Nyska A., Pras M., Livneh A.: An ancillary tool for the diagnosis of amyloid A amyloidosis in a variety of domestic and wild animals. Amer. Coll. Vet. Path. 2005, 42, 132-139.
• Slauson D., Gribble D., Russell S.: A clinicopathological study of renal amyloidosis in dogs. J. Comp. Pathol. 1970, 80, 335-343.
• Veglio F., Paglieri C., Rabbia F., Bisbocci D., Bergui M., Cerrato P.: Hypertension and cerebrovascular damage. Atheroscler. 2009, 205, 331-341.

Identyfikatory

DOI

10.21521/mw.6038