Immune stress up regulates TLR4 and Tollip gene expression in the hypothalamus of ewes

• Autorzy: Herman A.P. , Herman A. , Haziak K. , Tomaszewska-Zaremba D.
• Języki publikacji: EN

Abstrakty

EN

Bacterial endotoxin, LPS, is recognized by Toll-like receptor-4 (TLR4) and induces a signaling cascade leading to synthesis of proinflammatory cytokines and induction of sickness behavior in animals. Transduction of the TLR4 signal is controlled by a potent negative regulator—Toll-interacting protein. The presented study concerns the effect of intravenously injected LPS on the level of expression of TLR4 and Tollip genes in the hypothalamus of ewes. Endotoxin increased (P < 0.01) cortisol release and expression of TLR4 and Tollip genes in the preoptic area (1.87 ± 0.42 and 1.31 ± 0.15), anterior hypothalamus (1.77 ± 0.22 and 1.27 ± 0.13), medial basal hypothalamus (2.53 0.65 and 1.43 ± 0.15), and median eminence (2.93 ± 0.46 and 1.73 ± 0.10), respectively, in comparison with non-treated animals. Our results show that immune stress increases TLR4 gene expression in the hypothalamus. Increased transcription of Tollip may be an attempt to reduce the effect of TLR4 stimulation.

• Wydawca: -
• Czasopismo: Journal of Animal and Feed Sciences
• Rocznik: 2013
• Tom: 22
• Numer: 1
• Opis fizyczny: p.13-18,fig.,ref.

Twórcy

autor

Herman A.P.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

autor

Herman A.

• The Academy of Cosmetics and Health Care in Warsaw, 00-252 Warsaw, Poland

autor

Haziak K.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

autor

Tomaszewska-Zaremba D.

• The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jablonna, Poland

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