Enriched environment increases the total number of CNPase positive cells in the corpus callosum of middle-aged rats

• Autorzy: Zhao Y.-Y. , Shi X.-Y. , Qiu X. , Zhang L. , Lu W. , Yang S. , Li C. , Cheng G.-H. , Yang Z.-W. , Tang Y.
• Języki publikacji: EN

Abstrakty

EN

It had been reported that enriched environment was beneficial for the brain cognition, neurons and synapses in cortex and hippocampus. With diffusion tensor imaging (DTI), several studies recently found the trained-induced larger corpus callosum. However, the effect of enriched environment on the oligodendrocytes in corpus callosum has not been explored with the unbiased stereological methods. In current study, the effect of enriched environment on the total number of 2',3'- cyclic nucleotide 3'-phosphodiesterase (CNPase) positive cells in middle-aged rat corpus callosum was investigated by means of immunohistochemical techniques and the unbiased stereological methods. We found that, when compared to standard rats, the spatial learning capacity of enriched-environment rats was significantly increased. The total number of the CNPase positive cells in the corpus callosum of enriched-environment middle-aged rats was significantly increased when compared to standard rats. The present study provided, to the best of our knowledge, the first evidence of environmental enrichment-induced increases in the total number of CNPase positive cells in the corpus callosum of middle-aged rats.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: 3
• Opis fizyczny: p.322-330,fig.,ref.

Twórcy

autor

Zhao Y.-Y.

• Department of Histology and Embryology, Chongqing Medical University, Chongqing, P.R. China
• Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, P.R. China

autor

Shi X.-Y.

• Department of Histology and Embryology, Chongqing Medical University, Chongqing, P.R. China
• Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, P.R. China
• Department of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing, P.R. China

autor

Qiu X.

• Key Laboratory of Diagnostic Medicine (Ministry of Education), Department of Laboratory Medicine, Chongqing Medical University, Chongqing, P.R. China

autor

Zhang L.

• Key Laboratory of Diagnostic Medicine (Ministry of Education), Department of Laboratory Medicine, Chongqing Medical University, Chongqing, P.R. China

autor

Lu W.

• Department of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing, P.R. China

autor

Yang S.

• Department of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing, P.R. China

autor

Li C.

• Department of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing, P.R. China

autor

Cheng G.-H.

• Department of Histology and Embryology, Chongqing Medical University, Chongqing, P.R. China
• Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, P.R. China

autor

Yang Z.-W.

• Morphometric Research Laboratory, North Sichuan Medical College, Nanchong, P.R. China

autor

Tang Y.

• Department of Histology and Embryology, Chongqing Medical University, Chongqing, P.R. China
• Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, P.R. China

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