Oxidative status and lipid profile in mono- and co-infection with canine monocytic ehrlichiosis

• Autorzy: Gultekin M. , Ural K. , Pasa S. , Balikci C. , Asici G.S.E.
• Języki publikacji: EN

Abstrakty

EN

Vector-borne diseases in dogs are a major health problem of zoonotic importance. Canine monocytic ehrlichiosis (CME) is one of the most common vector-borne infections in dogs. Co-infections with vectorborne diseases are reported to cause more severe pathological effects than mono-infections. The current study investigates the effects of mono- and co-infections with CME on oxidative status and lipid profiles in dogs. Dogs with vector-borne diseases were divided into two groups, mono-infected (n = 22) and co-infected (n = 23) with CME, and compared to a healthy group (n = 20). Double and triple co-infections with other vector-borne diseases included A. phagocytophilum, L. infantum, and D. immitis. The serum lipid profile (high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, and triglycerides) and the total and individual markers of oxidative status (total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), paraoxonase (PON-1), and arylesterase (ARE)) were evaluated. Significant decreases in PON-1 and ARE enzyme activities and HDL concentration, as well as increases in TOS level, MDA, LDL, and triglyceride concentrations were determined in both mono- and co-infected groups compared to the healthy control group. No significant differences between the groups were found in the TAC level or cholesterol concentration. In conclusion, alterations in lipid profile and increase in oxidative stress were observed in dogs with CME compared to the healthy control group, however, no significant differences were detected between mono- and co-infected dogs.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2017
• Tom: 73
• Numer: 12
• Opis fizyczny: p.797-781,fig.,ref.

Twórcy

autor

Gultekin M.

• Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydin, Turkey

autor

Ural K.

• Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydin, Turkey

autor

Pasa S.

• Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydin, Turkey

autor

Balikci C.

• Department of Internal Medicine, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydin, Turkey

autor

Asici G.S.E.

• Department of Biochemistry, Faculty of Veterinary Medicine, University of Adnan Menderes, Aydin, Turkey

Bibliografia

• Bauer J. E.: Lipoprotein-mediated transfer of dietary and synthesized lipids and lipid abnormalities of dogs and cats. J. Am. Vet. Med. Assoc. 2004, 224, 668-675.
• Bottari N. B., Crivellenti L. Z., Borin-Crivellenti S., Oliveira J. R., Coelho S. B., Contin C. M., Tatsch E., Moresco R. N., Santana A. E., Tonin A. A., Tinucci-Costa M.: Iron metabolism and oxidative profile of dogs naturally infected by Ehrlichia canis: Acute and subclinical disease. Microb. Pathog. 2016, 92, 26-29.
• Cardoso L., Mendão C., de Carvalho L. M.: Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in apparently healthy and CVBD-suspect dogs in Portugal – a national serological study. Parasit. Vectors 2012, 5, 62.Cardoso L., Yisaschar-Mekuzas Y., Rodrigues F. T., Costa Á., Machado J., Diz-Lopes D., Baneth G.: Canine babesiosis in northern Portugal and molecular characterization of vector-borne co-infections. Parasit. Vectors 2010, 3, 27.
• Carpentier Y. A., Scruel O.: Changes in the concentration and composition of plasma lipoproteins during the acute phase response. Curr. Opin. Clin. Nutr. Metab. Care 2002, 5, 153-158.
• Chaudhuri S., Varshney J. P., Patra R. C.: Erythrocytic antioxidant defense, lipid peroxides level and blood iron, zinc and copper concentrations in dogs naturally infected with Babesia gibsoni. Res. Vet. Sci. 2008, 85, 120-124.
• Cunha B. A., Crean J., Rosenbaum G.: Lipid abnormalities in babesiosis. Am. J. Med. 2000, 108, 758-759.
• Da Silva A. S., Tonin A. A., Thorstenberg M. L., Leal D. B., Fighera R., Flores M. M., Lopes S. T.: Relationship between butyrylcholinesterase activity and liver injury in mice acute infected with Toxoplasma gondii. Pathol. Res. Pract. 2013, 209, 95-98.
• De Tommasi A. S., Otranto D., Dantas-Torres F., Capelli G., Breitschwerdt E. B., de Caprariis D.: Are vector-borne pathogen co-infections complicating the clinical presentation in dogs? Parasit. Vectors 2013, 6, 97.
• Durgut R., Dalkilinc D., Güzel M.: Evaluation of the serum lipid profiles in dogs with symptomatic Visceral Leishmaniasis. Kafkas University of Veterinary Fak. Derg. 2012, 18, 585-588.
• Elkiran E. T., Mar N., Aygen B., Gursu F., Karaoglu A., Koca S.: Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population. BMC Cancer 2007, 7, 48.
• Erel O.: A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin. Biochem. 2004, 37, 277-285.
• Erel O.: A new automated colorimetric method for measuring total oxidant status. Clin. Biochem. 2005, 38, 1103-1111.
• Gaunt S., Beall M., Stillman B., Lorentzen L., Diniz P., Chandrashekar R., Breitschwerdt E.: Experimental infection and co-infection of dogs with Anaplasma platys and Ehrlichia canis: hematologic, serologic and molecular findings. Parasit. Vectors 2010, 3, 33.
• Harrus S., Waner T.: Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): an overview. Vet. J. 2011, 187, 292-296.
• Karnezi D., Ceron J. J., Theodorou K., Leontides L., Siarkou V. I., Martinez S., Tvarijonaviciute A., Harrus S., Koutinas C. K., Pardali D., Mylonakis M. E.: Acute phase protein and antioxidant responses in dogs with experimental acute monocytic ehrlichiosis treated with rifampicin. Vet. Microbiol. 2016, 184, 59-63.
• Kocaturk M., Tvarijonaviciute A., Martinez Subiela S., Tecles F., Eralp O., Yilmaz Z., Ceron J. J.: Inflammatory and oxidative biomarkers of disease severity in dogs with parvoviral enteritis. J. Small Anim. Pract. 2015, 56, 119-124.
• Kogika M. M., Lustoza M. D., Hagiwara M. K., Caragelasco D. S., Martorelli C. R., Mori C. S.: Evaluation of oxidative stress in the anemia of dogs with chronic kidney disease. Vet. Clin. Pathol. 2014, 44, 70-78.
• Kuleš J., de Torre-Minguela C., Rafaj R. B., Gotić J., Nižić P., Ceron J. J., Mrljak V.: Plasma biomarkers of SIRS and MODS associated with canine babesiosis. Res. Vet. Sci. 2016, 105, 222-228.
• Kuleš J., Mrljak V., Rafaj R. B., Selanec J., Burchmore R., Eckersall P. D.: Identification of serum biomarkers in dogs naturally infected with Babesia canis canis using a proteomic approach. BMC Vet. Res. 2014, 10, 111.
• Kumar A., Varshney J. P., Patra R. C.: A comparative study on oxidative stress in dogs infected with Ehrlichia canis with or without concurrent infection with Babesia gibsoni. Vet. Res. Commun. 2006, 30, 917-920.
• Lin M., Rikihisa Y.: Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival. Infect. Immun. 2003, 71, 5324-5331.
• Litvinov D., Mahini H., Garelnabi M.: Antioxidant and anti-inflammatory role of paraoxonase 1: implication in arteriosclerosis diseases. N. Am. J. Med. Sci. 2012, 4, 523-532.
• Martinez-Subiela S., Cerón J. J., Strauss-Ayali D., Garcia-Martinez J. D., Tecles F., Tvarijonaviciute A., Caldin M., Baneth G.: Serum ferritin and paraoxonase-1 in canine leishmaniosis. Comp. Immunol. Microbiol. Infect. Dis. 2014, 37, 23-29.
• Mrljak V., Kučer N., Kuleš J., Tvarijonaviciute A., Brkljačić M., Crnogaj M., Rafaj R. B.: Serum concentrations of eicosanoids and lipids in dogs naturally infected with Babesia canis. Vet. Parasitol. 2014, 201, 24-30.
• Nakamura T., Reicher H., Sattler W.: Comparison of RRR-α-and all-rac-α-tocopherol uptake by permanent rat skeletal muscle myoblasts (L6 cells): effects of exogenous lipoprotein lipase. Lipids 1998, 33, 1001-1008.
• Nieto C. G., Barrera R., Habela M. A., Navarrete I., Molina C., Jiménez A., Serrera J. L.: Changes in the plasma concentrations of lipids and lipoprotein fractions in dogs infected with Leishmania infantum. Vet. Parasitol. 1992, 44, 175-182.
• Otranto D., Dantas-Torres F., Breitschwerdt E. B.: Managing canine vector-borne diseases of zoonotic concern: part one. Trends Parasitol. 2009a, 25, 157-163.
• Otranto D., Dantas-Torres F., Breitschwerdt E. B.: Managing canine vector-borne diseases of zoonotic concern: part two. Trends Parasitol. 2009b, 25, 228-235.
• Rikihisa Y.: Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nat. Rev. Microbiol. 2010, 8, 328-339.
• Rossi G., Ibba F., Meazzi S., Giordano A., Paltrinieri S.: Paraoxonase activity as a tool for clinical monitoring of dogs treated for canine leishmaniasis. Vet. J. 2014, 199, 143-149.
• Rubio C. P., Hernández-Ruiz J., Martinez-Subiela S., Tvarijonaviciute A., Ceron J. J.: Spectrophotometric assays for total antioxidant capacity (TAC) in dog serum: an update. BMC Vet. Res. 2016, 12, 166.
• Rudoler N., Harrus S., Martinez-Subiela S., Tvarijonaviciute A., van Straten M., Cerón J. J., Baneth G.: Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. Parasit. Vectors 2015, 8, 175.
• Ruiz-Tapia P., Zaragoza-Bayle C., Duque-Carrasco F. J., Barrera-Chacón R.: Changes in plasma lipid profile in dogs with cutaneous diseases. Rev. Cient-Fac. Cien. V. 2014, 24, 502-508.
• Sainz Á., Roura X., Miró G, Estrada-Peña A., Kohn B., Harrus S., Solano-Gallego L.: Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. Parasit. Vectors 2015, 8, 75.
• Sarma K., Mondal D., Saravanan M., Mahendran K.: Evaluation of haemato-biochemical and oxidative indices in naturally infected concomitant tick borne intracellular diseases in dogs. Asian Pac. J. Trop. Dis. 2015, 5, 60-66.
• Siewert S., Gonzalez I. I., Lucero R. O., Ojeda M. S.: Association of cholesteryl ester transfer protein genotypes with paraoxonase 1 activity, lipid profile and oxidative stress in type 2 diabetes mellitus: A study in San Luis, Argentina. J. Diabetes Investig. 2015, 6, 67-77.
• Tunc H. O., Aktas M. S.: Tick-Borne Diseases in Dogs in Turkey. Erciyes Univ. Vet. Fak. Derg. 2016, 13, 223-230.
• Tvarijonaviciute A., García Martínez J. D., Caldin M., Martínez-Subiela S., Tecles F., Pastor J., Ceron J. J.: Serum paraoxonase 1 (PON1) activity in acute pancreatitis of dogs. J. Small Anim. Pract. 2015, 56, 67-71.
• Ural K., Gultekin M., Atasoy A., Ulutas B.: Spatial distribution of vector borne disease agents in dogs in Aegean region, Turkey. Rev. MVZ Córdoba 2014, 19, 4086-4098.
• Yoshoiko T., Kawada K., Shimada T.: Lipid peroxidation in maternal and cord blood and protective mechanism against activated-oxygen toxicity in the blood. Am. J. Obstet. Gynecol. 1979, 135, 372-376.

Identyfikatory

DOI

10.21521/mw.5817