P-R interval in porcine model of chronic tachycardia-induced cardiomyopathy

• Autorzy: Skrzypczak P. , Zysko D. , Paslawska U. , Noszczyk-Nowak A. , Janiszewski A. , Kiczak L. , Bania J. , Zacharski M. , Tomaszek A. , Rybinska I. , Nicpon J. , Paslawski R. , Gajek J. , Jankowska E. A. , Ponikowski P.
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to assess the atrioventricular conduction in the model of porcine pacing induced tachycardiomyopathy. Fifty-one swine were examined: 27 were paced and 24 served as a control group. Every 4 weeks, the animals were anaesthetised for 1 h and an ECG Holter was performed. Thirty minutes after the onset of anaesthesia, P-R and R-R intervals were measured. Each result was assigned to the subgroup according to the animal's weight and the presence or absence of previous pacing. P-R interval was longer in animals after at least 4 weeks of rapid ventricular stimulation than in adjusted group of the animals according to the body mass. Multivariate analysis has showed that longer P-R interval was related to male gender, higher body mass, slower heart rate, and history of previous pacing. Chronic ventricular pacing led to the slowing of atrioventricular conduction. The presence of differences in the duration of R-R intervals between groups was only found in swine weighing 120-139 kg. The R-R interval was shorter in paced animals, whereas PR interval was longer in that group, indicating that PR prolongation is related to electrical or structural remodelling of the cardiac conductive tissue but not increased sympathetic nervous system activity, which is expected to produce corresponding changes in PR and R-R intervals.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2013
• Tom: 57
• Numer: 3
• Opis fizyczny: p.437-441,fig.,ref.

Twórcy

autor

Skrzypczak P.

• Department of Surgery, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Zysko D.

• Department of Emergency Medicine, Wroclaw Medical University, 50-366 Wroclaw, Poland Research and Development Centre 3Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland

autor

Paslawska U.

• Department of Internal Diseases with Clinic for Horses, Dogs, and Cats, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland
• Department of Food Hygiene and Consumer Health Protection, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Noszczyk-Nowak A.

• Department of Internal Diseases with Clinic for Horses, Dogs, and Cats, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland
• Department of Food Hygiene and Consumer Health Protection, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Janiszewski A.

• Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland

autor

Kiczak L.

• Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland
• Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Bania J.

• Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland
• Department of Food Hygiene and Consumer Health Protection, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Zacharski M.

• Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland
• Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Tomaszek A.

• Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland
• Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Rybinska I.

• Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland
• Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Nicpon J.

• Department of Internal Diseases with Clinic for Horses, Dogs, and Cats, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland
• Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland

autor

Paslawski R.

• Regional Specialist Hospital in Wroclaw, 51-124 Wroclaw, Poland
• Department and Clinic of Internal and Occupational Diseases and Hypertension, Wroclaw University of Environmental and Life Sciences, 50-366 Wroclaw, Poland

autor

Gajek J.

• Department of Heart Diseases, Wroclaw Medical University, 50-367 Wroclaw, Poland

autor

Jankowska E. A.

• Centre for Heart Diseases, Military Hospital, 50-891 Wroclaw, Poland

autor

Ponikowski P.

• Centre for Heart Diseases, Military Hospital, 50-891 Wroclaw, Poland

Bibliografia

• 1. Bimer C., Husser O., Jeron A., Rihm M., Fredersdorf S., Resch M., Schmid P., Endemann D., Riegger G., Luchner A.: Differential expression of potassium channels and abnormal conduction in experimental tachycardia induced heart failure. Naunyn Schmiedebergs Arch Pharmacol 2012. (Epub ahead of print).
• 2. Cabasson A., Meste O., Blain G., Bermon S.: Quantifying the PR interval pattern during dynamic exercise and recovery. IEEE Trans Biomed Eng 2009, 56, 2675-2683.
• 3. Cha T.J., Ehrlich J.R., Zhang L., Nattel S.: Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure. Circulation 2004, 110, 1520-1526.
• 4. Craft N., Schwartz J.: Effects of age on intrinsic heart rate, heart rate variability, and AV conduction in healthy humans. Am J Physiol 1995, 268, 1441-1452.
• 5. Doering W., König E., Sturm W.: Digitalis intoxication: specifity and significance of cardiac and extracardiac symptoms. Part I. Patients with digitalis induced arrhythmias. Z Kardiol 1977, 66, 121-128.
• 6. Fleg J.L., Das D.N., Wright J., Lakatta E.G.: Age-associated changes in the components of atrioventricular conduction in apparently healthy volunteers. J Gerontol 1990, 45, 95-100.
• 7. Hadian D., Zipes D.P., Olgin J.E., Miller J.M.: Short-term rapid atrial pacing produces electrical remodeling of sinus node function in humans J Cardiovasc Electrophysiol 2002, 13, 584- 586.
• 8. Han W., Chartier D., Li D., Nattel S.: Ionic remodeling of cardiac Purkinje cells by congestive heart failure. Circulation 2001, 104, 2095-2100.
• 9. Hanson B., Tuna N., Bouchard T., Heston L., Eckert E., Lykken D., Segal N., Rich S.: Genetic factors in the electrocardiogram and heart rate of twins reared apart and together Am J Cardiol 1989, 63, 606-609.
• 10. Kannankeril P.J., Donahue B.S., Roden D.M., Darbar D.: ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling. Heart Rhythm 2009, 6, 1327-1332.
• 11. Kinoshita S., Konishi G.: Mechanisms of atypical atrioventricular Wenckelbach periodicity. J Electrocardiol 1989, 22, 227- 233.
• 12. Koike Y., Shimamura K., Shudo I., Saito H.: Pharmacokinetics of verapamil in man. Res Commun Chem Pathol Pharmacol 1979, 24, 37-47.
• 13. Laitinen T., Lyyra-Laitinen T., Huopio H., Vauhkonen I., Halonen T., Hartikainen J., Niskanen L., Laakso M.: Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects. Ann Noninvasive Electrocardiol 2008, 13, 97-105.
• 14. Levy M.N., Zieske H.: Autonomic control of cardiac pacemaker activity and atrioventricular transmission. J App Physiol 1969, 27, 465-470.
• 15. Li D., Melnyk P., Feng J., Wang Z., Petrecca K., Shrier A., Nattel S.: Effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation 2008, 101, 2631-2638.
• 16. Mathers J.A., Osborne R.H., Degeorge F.V.: Studies of blood pressure, heart rate, and the electrocardiogram in adult twins Am Heart J 1961, 62, 634-642.
• 17. Meijler F.L., Strackee J., Stokhof A.A., Wassenaar C.: Scaling of atrioventricular transmission in mammalian species: an evolutionary riddle! J Cardiovasc Electrophysiol 2002, 13, 826- 830.
• 18. Nattel S.: New ideas about atrial fibrillation 50 years on. Nature 2002, 415, 219-226.
• 19. O'Connor M., McDaniel N., Brady W.J.: The pediatric electrocardiogram: part I: Age-related interpretation. Am J Emerg Med 2008, 26, 506-512.
• 20. Pasławska U., Zyślo D., Noszczyk-Nowak A., Pasławski R.: Short-term and long-term PQ, QT and R-R intervals' variability at the resting condition and after exercise testing in healthy Anglo-Arabian horses. Polish J Vet Sci 2012, 15, 55-59.
• 21. Pasławska U., Gajek J., Kiczak L., Noszczyk-Nowak A., Skrzypczak P., Bania J., Tomaszek A., Zacharski M., Sambor I., Dziegiel P., Zysko D., Banasiak W., Jankowska E.A., Ponikowski P.: Development of porcine model of chronic tachycardia-induced cardiomyopathy. Int J Cardiol 2011, 153, 36-41.
• 22. Pasławska U., Noszczyk-Nowak A., Kungl K., Bioły K., Popiel J., Nicpoń J.: Thyroid hormone activity and ECG picture in dog. Polish J Vet Sci 2006, 9, 253-257.
• 23. Ramirez R.J., Nattel S., Courtemanche M.: Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling. Am J Physiol Heart Cire Physiol 2000, 279, 1767-1785.
• 24. Skasa M., Jungling E., Picht E., Schondube F., Luckhoff A.: L-type calcium currents in atrial myocytes from patients with persistent and non-persistent atrial fibrillation. Basic Res Cardiol 2001, 96, 151-159.
• 25. Smith R.F., Stanton K., Stoop D., Janusz W., King P.H.: Quantitative electrocardiography during extended space flight: the second manned skylab mission. Aviat Space Environ Med 1976, 47, 353-359.
• 26. Stambler B.S., Fenelon G., Shepard R.K., Cierno H.F., Guiraudon C.M.: Characterization of sustained atrial tachycardia in dogs with rapid ventricular pacing-induced heart failure. J Cardiovasc Electrophysiol 2003, 14, 499-507.
• 27. Taneja T., Mahnert B.W., Passman R., Goldberger J., Kadish A.: Effects of sex and age on electrocardiographic and cardiac electrophysiological properties in adults. Pacing Clin Electrophysiol 2001, 24, 16-21.
• 28. White P.D.: The follow-up of the normal heart. Isr J Med Sci 1965, 1, 875-882.
• 29. Workman A.J., Kane K.A., Rankin A.C.: The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovasc Res 2001, 52, 226-235.
• 30. Yue L., Feng J., Gaspo R., Li G.R., Wang Z., Nattel S.: Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res 1997, 81, 512-525.
• 31. Yue L., Melnyk P., Gaspo R., Wang Z., Nattel S.: Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. Circ Res 1999, 84, 776-784.
• 32. Zyśko D.. Gajek J., Koźluk E., Mazurek W.: Electrocardio-graphic characteristics of atrioventricular block induced by tilt testing. Europace 2009, 11, 225-230.

Identyfikatory

DOI

10.2478/bvip-2013-0076