Warianty tytułu
Języki publikacji
Abstrakty
We study the mechanisms of neurogenesis in order to implement them for neuronal repair. I will present unpublished work about the molecular function of Trnp1, a novel nuclear protein, with key roles in promoting neural stem cell self‑renewal and neurogenesis. Trnp1 shows unprecedented functions in regulating several nuclear processes by its N-terminal intrinsically disordered region, which is highly conserved in mammals. I will then show that Trnp1 is also critical for direct neuronal reprogramming and provide an update on the recent breakthrough in direct glia-to-neuron conversion after brain injury. I will then move on to discuss the integration of replaced neurons into the circuitry of the murine cerebral cortex – that normally does not integrate new neurons at adult stages – and present unpublished data about the mechanisms regulating this integration. Taken together, our knowledge about basic mechanisms of neurogenesis allows us to make great strides towards neuronal repair.
Wydawca
Czasopismo
Rocznik
Tom
Numer
Opis fizyczny
p.XX
Twórcy
autor
- Helmholtz Center Munich and Biomedical Center, Institute for Stem Cell Research, University of Munich, Munich, Germany
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-0401b22b-f6af-48e5-8471-0ed51302f23c