The index of insulin resistance (FIRI) is not associated with plasma homocysteine levels in young, non-obese healthy men and women

• Autorzy: Anna Czajkowska , Grażyna Lutosławska , Krzysztof Mazurek , Jadwiga Ambroszkiewicz , Piotr Żmijewski
• Języki publikacji: EN

Abstrakty

EN

Study aim: To evaluate plasma homocysteine (Hcy), insulin and glucose levels in blood and the insulin resistance index (FIRI) in young, healthy non-obese men and women.Material and methods: A total of 152 young, healthy, non-obese (BMI<30) men (n = 81) and women (n = 71) participated in the study. The following substances were assayed in blood using commercial kits: total plasma homocysteine by fluorescence polarisation immunoassay, plasma glucose - by the oxidase method, and insulin by radioimmunoassay using monoclonal antibodies. From the latter two, the index of insulin resistance (FIRI) was computed.Results: Mean plasma homocysteine concentration in men was significantly (p<0.001) higher than in women (10.3 ± 3.0 and 8.4 ± 2.4 μmol/l, respectively) and that of FIRI was significantly (p<0.001) lower than in women (1.310 ± 0.483 and 1.437 ± 0.420, respectively). Neither in men nor in women were plasma homocysteine concentrations correlated with FIRI.Conclusions: Although no association between circulating homocysteine and FIRI was found in young, non-obese men and women, the existence of such association in Type 2 diabetes cannot be ruled out.

Słowa kluczowe

EN

Homocysteine; Insulin resistance index; Non-obese subjects

• Czasopismo: Biomedical Human Kinetics
• Rocznik: 2011
• Tom: 3
• Strony: 14-17

Daty

wydano

2011-01-01

online

2011-03-03

Twórcy

autor

Anna Czajkowska

• Department of Physiology, University of Physical Education, Warsaw, Poland

autor

Grażyna Lutosławska

• Department of Biochemistry, University of Physical Education, Warsaw, Poland

autor

Krzysztof Mazurek

• Department of Sports Medicine, University of Physical Education, Warsaw, Poland

autor

Jadwiga Ambroszkiewicz

• Department of Newborn Screening, Institute of Mother and Child, Warsaw, Poland

autor

Piotr Żmijewski

• Department of Physiology, Institute of Sport, Warsaw, Poland

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Identyfikatory

DOI

10.2478/v10101-011-0004-7