Non Small Cell Lung Cancer: Is There a Relationship Between Bacterial Colonization of the Tumour Parenchyma and Postoperative Infectious Complications?

• Autorzy: Maciej Dancewicz , Maria Szymankiewicz , Janusz Kowalewski , Mariusz Bella
• Języki publikacji: EN

Abstrakty

EN

The aim of the study was to investigate the influence of bacterial colonisation of a neoplastic lung tumour on the frequency of infectious complications after radical surgical treatment of the malignancy.Material and methods. 49 patients operated on for non-small cell lung cancer (NSCLC) from 23rd January to 2nd November 2006 were included into the study. The analyzed group consisted of 39 men and 10 women, they were from 45 to 79 years old. Material for microbiological tests was collected in an operating theatre under sterile conditions directly after the resection of a tumour. A sample (5x5x5 mm) of the tumour was cultured for facultative anaerobes, obligate anaerobes and fungi. After the homogenisation of tumour tissues quantitative culture was also performed.Results. Potentially pathogenic microbes were cultured from tumours in 14 patients (28.6%). The most frequent bacterium was Propionibacterium acnes. It was found in six out of 49 tumours (12.2%). In 13 cases (26.6%) postoperative infectious complications were observed. They were as follows: infection of the lower airways - 8 cases (16.3%), surgical wound infection - 3 cases (6.1%), pleurisy - 1 case (2%) and pleural empyema - 1 case (2%). In 12 patients (24.5%) pathogenic microbes were isolated from biological material obtained from other sources than a tumour. In remaining 36 patients (73.5%) no infectious postoperative complications were observed. In 13 patients in whom bacteria were cultured from a tumour there were no postoperative infectious complications. Only in one patient the same bacterium (Staphylococcus aureus) was identified in a tumour and 35 days later in pleural effusion where four other pathogenic bacteria were isolated, too. In 12 patients whose postoperative course was complicated by infections had no pathogenic microbes cultured from a resected tumour. Statistical analysis showed no significant relations between the presence of pathogenic microbes within a lung malignant tumour and postoperative infectious complications in patients.Conclusions. The most frequent microbe cultured from non-small cell lung carcinoma is Propionibacterium acnes. There is no relation between the colonisation of a malignant tumour by bacteria and postoperative complications in patients treated surgically for NSCLC.

Słowa kluczowe

EN

lung carcinoma; postoperative complications; postoperative pneumonia

• Wydawca: Index Copernicus International
• Czasopismo: Polish Journal of Surgery
• Rocznik: 2008
• Tom: 80
• Numer: 1
• Strony: 21-25

Daty

wydano

2008-01-01

online

2008-02-18

Twórcy

autor

Maciej Dancewicz

• Department and Clinic of Thoracic Surgery and Tumors, The L. Rydygier Collegium Medicum in Bydgoszcz, Mikołaj Kopernik University, Toruń

autor

Maria Szymankiewicz

• Microbiology DPT of Oncology Center, Bydgoszcz

autor

Janusz Kowalewski

• Department and Clinic of Thoracic Surgery and Tumors, The L. Rydygier Collegium Medicum in Bydgoszcz, Mikołaj Kopernik University, Toruń

autor

Mariusz Bella

• Department and Clinic of Thoracic Surgery and Tumors, The L. Rydygier Collegium Medicum in Bydgoszcz, Mikołaj Kopernik University, Toruń

Bibliografia

• Ioanas M, Angrill J, Baldo X et al.: Bronchial bacterial colonization in patients with respectable lung carcinoma. Eur Respir J 2002; 19: 326-32.
• Algar FJ, Alvarez A, Salvatierra A et al.: Predicting pulmonary complications after pneumonectomy for lung cancer. European Journal of Cardio-thoracic Surgery 2003; 23: 201-08.
• Busch E, Verazin G, Antkowiak JG: Pulmonary complications in patients undergoing thoracotomy for lung carcinoma. Chest 1994; 105: 760-66.
• Mitsudomi T, Mizoue T, Yoshimatsu T et al.: Postoperative complications after pneumonectomy for treatment of lung cancer: multivariate analysis. J Surg Oncol 1996; 61: 218-22.
• Duque JL, Ramons G, Castrodeza J: Early complications in surgical treatment of lung cancer: a prospective multicenter study. Ann Thoracic Surg 1997; 63: 944-50.
• Belda J, Cavalcanti M, Ferrer M et al.: Bronchial colonization and postoperative respiratory infections in patients undergoing lung cancer surgery. Chest 2005; 128(3): 1571-79.
• Liao WY, Liaw YS, Wang HC et al.: Bacteriology of infected cavitating lung tumor. Am J Respir Crit Care Med 2000; 161: 1750-53.
• Seo SK: Infectious complications of lung cancer. Oncology 2005; 19(2): 185-94; discussion 195-6, 199-203, 207-08.
• Sok M, Dragas AZ, Erzen J et al.: Sources of pathogens causing pleuropulmonary infections after lung cancer resection. Eur J Cardio-thoracic Surg 2002; 22: 23-29.
• Schussler O, Alifano M, Dermine H et al.: Postoperative pneumonia after major lung resection. Am J Respir Crit Care Med 2006; 173: 1161-69.
• Sarihan S, Ercan I, Saran A et al.: Evaluation of infections in non-small cell lung cancer patients treated with radiotherapy. Cancer Detect Prev 2005; 29: 181-88.
• Klastersky J: The infectious complications of bronchial cancer. (in French). Rev Mal Respir 1998; 15(4): 451-59.[PubMed]
• Zając-Lenczewska I: Wpływ występowania drobnoustrojów beztlenowych w dolnych drogach oddechowych na przebieg pooperacyjny chorych na nowotwór płuca (rozprawa doktorska). Akademia Medyczna Gdańsk 2004.

Identyfikatory

DOI

10.2478/v10035-007-0128-1