Quiescent satellite glial cells of the adult trigeminal ganglion

• Autorzy: Mugurel Rusu , Valentina Mănoiu , Nicolae Mirancea , Gheorghe Nini
• Języki publikacji: EN

Abstrakty

EN

Sensory ganglia comprise functional units built up by neurons and satellite glial cells (SGCs). In animal species there was proven the presence of neuronoglial progenitor cells in adult samples. Such neural crest-derived progenitors were found in immunohistochemistry (IHC). These findings were not previously documented in transmission electron microscopy (TEM). It was thus aimed to assess in TEM if cells of the human adult trigeminal ganglion indeed have ultrastructural features to qualify for a progenitor, or quiescent phenotype. Trigeminal ganglia were obtained from fifteen adult donor cadavers. In TEM, cells with heterochromatic nuclei, a pancytoplasmic content of free ribosomes, few perinuclear mitochondria, poor developed endoplasmic reticulum, lack of Golgi complexes and membrane trafficking specializations, were found included in the neuronal envelopes built-up by SGCs. The ultrastructural pattern was strongly suggestive for these cells being quiescent progenitors. However, further experiments should correlate the morphologic and immune phenotypes of such cells.

Słowa kluczowe

EN

Sensory ganglion; Transmission electron microscopy; Satellite glial cells; Progenitor cells; Human trigeminal ganglion

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 9
• Numer: 3
• Strony: 500-504

Daty

wydano

2014-06-01

online

2014-07-08

Twórcy

autor

Mugurel Rusu,

autor

Valentina Mănoiu

• Faculty of Geography, University of Bucharest, 050107, Bucharest, Romania

autor

Nicolae Mirancea

• Institute of Biology of Bucharest — The Romanian Academy, 060031, Bucharest, Romania

autor

Gheorghe Nini

• Faculty of Medicine, Pharmacy and Dental Medicine, “Vasile Goldiş” Western University, 310045, Arad, Romania

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Identyfikatory

DOI

10.2478/s11536-013-0285-z