Population pharmacokinetic of antiepileptic drugs in different populations

• Autorzy: Jasmina Milovanovic , Slobodan Jankovic
• Języki publikacji: EN

Abstrakty

EN

This article reviews a population pharmacokinetics studies conducted during the past few years in Serbia. Studies have included three the most frequently used antiepileptic drugs (valproate, carbamazepine and lamotrigine) and different populations of epileptic patients: children, adults and heterogeneous population composed of both children and adults. The review compares obtained values of population pharmacokinetic models of clearance of these drugs, and factors that are significantly determined, making brief comments on the results of other authors on the same topic. Individualization of drug dosage is the basis of rational therapy, and factors of variability will always be subject of scientific research.

Słowa kluczowe

EN

Population pharmacokinetics; ENONMEM; Valproate; Carbamazepine; Lamotrigine

• Czasopismo: Open Medicine
• Rocznik: 2013
• Tom: 8
• Numer: 4
• Strony: 383-391

Daty

wydano

2013-08-01

online

2013-06-12

Twórcy

autor

Jasmina Milovanovic

• Pharmacology Department, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia,

autor

Slobodan Jankovic

• Pharmacology Department, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

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Identyfikatory

DOI

10.2478/s11536-013-0158-5