Czasopismo
Tytuł artykułu
Warianty tytułu
Języki publikacji
Abstrakty
The proteins of the fibrinolytic system - urokinase plasminogen activator(uPA), tissue plasminogen activator (tPA)and plasminogen activator inhibitor type IPAI-I) - play important roles in fibrotization in various organs and including peritoneum. To study the cellular localization of PAI-1, tPA and uPA within the adipose tissue of the peritoneal membrane in patients at the onset of peritoneal dialysis(PD) we determined the initial expression of these proteins in relationship to multiple clinical variables. Methods: routinely performed parietal peritoneal biopsies in 12 patients undergoing peritoneal catheter implantation were examined. We used formalinfixed, paraffin-embedded specimens for immunohistochemical localization of these proteins along with the stereological pointcounting method for quantification of their expression within the peritoneal adipose tissue. Results: strong positive mutual correlation between the expression of PAI-1 and both uPA (SpearmanR=0.66) and tPA (R=0.59) as well as between the expression of uPA and tPA (R=0.77) was found without any relatioship to BMI, age, peritoneal transport characteristic or diabetes status. Conclusion: Adipose tissue within the peritoneum is capable of producing fibrinolysis regulators (independently on clinical parameters) thus possibly affecting the fibrotization and function of peritoneum as dialysis membrane. The effect of dialysis solution dosing, composition and other dialysis related factors should be clarified in future studies.
Słowa kluczowe
Czasopismo
Rocznik
Tom
Numer
Strony
604-609
Opis fizyczny
Daty
wydano
2012-10-01
online
2012-07-28
Twórcy
autor
- Charles University Medical School and Teaching Hospital, 30166, Pilsen, Czech Republic, opatrna@fnplzen.cz
autor
autor
- Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, 30166, Pilsen, Czech Republic
autor
- Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, 30166, Pilsen, Czech Republic
autor
- Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, 30166, Pilsen, Czech Republic
autor
- Department of Preventative Medicine and Hygiene, Faculty of Medicine in Pilsen, Charles University in Prague, 30166, Pilsen, Czech Republic
Bibliografia
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- [2] Higuchi C, Tanihata Y, Nishimura H, Naito T, Sanaka T. Effects of glucose and plasminogen activator inhibitor-1 on collagen metabolism in the peritoneum. Ther Apher Dial 2005;9:173–181 http://dx.doi.org/10.1111/j.1774-9987.2005.00232.x
- [3] Kurata K Maruyama S, Kato S et al. Tissue-type plasminogen activator deficiency attenuates peritoneal fibrosis in mice. Am J Renal Physiol 2009;297:F1510–F157 http://dx.doi.org/10.1152/ajprenal.90330.2008[WoS][Crossref]
- [4] Aroeira LS, Aguilera A, Sánchez-Tomero JA, et al. Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions. J Am Soc Nephro. 2007;18:2004–2013 http://dx.doi.org/10.1681/ASN.2006111292[WoS][Crossref]
- [5] Yang J, Shultz RW, Mars WM et al. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest 2002;110:1525–1538 [Crossref][PubMed]
- [6] Sitter T, Spannagl M, Schiffl H, Held E, van Hinsbergh VW, Kooistra T. Imbalance betweein intraperitoneal coagulation and fibrinolysis during peritonitis of CAPD patients: the role of mesothelial cells. Nephrol Dial Tranpsplant 1995;10:677–683
- [7] Sitter T, Toet K, Fricke H, Schiffl H, Held E, Kooistra T. Modulation of procoagulant and fibrinolytic system components of mesothelial cells by inflammatory mediators. Am J Physiol Regul Integr comp Physiol 1996;271:1256–1263
- [8] Alessi MC, Bastelica D, Morange P et al. Plasminogen Activator Inhibitor 1, Transforming Growth Factor-β1, and BMI are closely associated in human adipose tissue during morbid obesity. Diabetes 2000;40: 1374–1380 http://dx.doi.org/10.2337/diabetes.49.8.1374[Crossref]
- [9] Samad F, Pandey M, Bell PA, Loskutoff DJ. Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insuline-resistant mice and adipocytes. Mol Med 2000;6:680–692
- [10] Salame MY, Samani NJ, Masood I, deBono DP. Expression of the plasminogen activator system in the human vascular wall. Atherosclerosis 2000;152:19–28 http://dx.doi.org/10.1016/S0021-9150(99)00441-4[Crossref]
- [11] Venugopal J, Hanashiro K, Nagamine Y. Regulation of PAI-1 gene expression during adipogenesis. J Cell Biochem 2007;101:369–380 http://dx.doi.org/10.1002/jcb.21173
- [12] Costa E, Rocha S, Rocha-Ferreira P et al. Crosstalk between inflammation, coagulation/fibrinolysis and vascular access in hemodialysis patients. J Vasc Access 2008:9:248–253
- [13] Irish AB. Plasminogen Activator Inhibitor-1 Activity in Chronic Renal Disease and Dialysis. Metabolism 1997:46(1):36–40 http://dx.doi.org/10.1016/S0026-0495(97)90164-5
- [14] Pini M, Rhodes DH, Fantuzzi G. Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice. Cytokine 2011:56:708–716 http://dx.doi.org/10.1016/j.cyto.2011.09.015[Crossref][WoS]
- [15] Peppa M, Uribarri J, Cai W, Lu M, Vlassara H. Glycoxidation and Inflammation in Renal Failure Patients. Am J Kidney Dis 2004:43(4):690–695 http://dx.doi.org/10.1053/j.ajkd.2003.11.022[Crossref]
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- [17] Faber DR, de Groot PG, Visseren FLJ. Role of adipose tissue in haemostasis, coagulation and fibrinolysis. Obesity Reviews 2009;10:554–563 http://dx.doi.org/10.1111/j.1467-789X.2009.00593.x[WoS][Crossref]
- [18] Bouchard L, Vohl MC, Lebel S et al. Contribution of genetic and metabolic syndrome to omental adipose tissue PAI-1 gene mRNA and plasma levels in obesity. Obes Surg 2010;20:492–499 http://dx.doi.org/10.1007/s11695-010-0079-1
- [19] Gabriely I, Yang XM, Cases JA, Ma XH, Rossetti L, Barzilai N. Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway. Atherosclerosis 2002;160:115–122 http://dx.doi.org/10.1016/S0021-9150(01)00574-3
Typ dokumentu
Bibliografia
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bwmeta1.element.-psjd-doi-10_2478_s11536-012-0042-8