Surgical treatment of gastrointestinal autonomic nerve tumors (GANT) in children-2 case reports

• Autorzy: Zoran Marjanovic , Andjelka Slavkovic , Marijana Krstic , Ivona Djodjevic , Dragan Dimov
• Języki publikacji: EN

Abstrakty

EN

Gastrointestinal autonomic nerve tumors form an uncommon subcategory of stromal tumors of the intestinal tract although their histologic appearance is similar to other gastrointestinal stromal tumors. Our aim was to evaluate our experience in the diagnosis and therapy of these kinds of tumors. Two patients were admitted to the Pediatric Surgery Clinic in Niš with abdominal pain and a palpable mass in the abdomen. After excision, the tumor tissue was sampled, sent for histopathological diagnosis, and examined by light microscopy, immunohistochemistry, and electron microscopy. Postoperatively, both patients recovered without complications. The patient with the tumor bulk in the mesentery of the small bowel had no evidence of tumor progression 6 years after surgery. In the second case, a giant tumor was present along the greater curvature of gaster. Even with a tumor of this size, there were no signs of progression 10 years after surgery. Radical surgical resection of gastrointestinal autonomic nerve tumors seems to be the curative approach to date, and long-term survival is possible even with large tumors.

Słowa kluczowe

EN

Autonomic nerve tumor; Immunohistochemistry; Children

• Czasopismo: Open Medicine
• Rocznik: 2011
• Tom: 6
• Numer: 4
• Strony: 395-399

Daty

wydano

2011-08-01

online

2011-06-01

Twórcy

autor

Zoran Marjanovic

• Pediatric Surgery Clinic, Clinical Center Nis, 18000, Nis, Republic of Serbia

autor

Andjelka Slavkovic

• Pediatric Surgery Clinic, Clinical Center Nis, 18000, Nis, Republic of Serbia

autor

Marijana Krstic

• Pediatric Surgery Clinic, Clinical Center Nis, 18000, Nis, Republic of Serbia

autor

Ivona Djodjevic

• Pediatric Surgery Clinic, Clinical Center Nis, 18000, Nis, Republic of Serbia,

autor

Dragan Dimov

• Institute of Pathology, Clinical Center Nis, 18000, Nis, Republic of Serbia

Bibliografia

• [1] Herrera GA, Pinto De Moraes H, Grizzle WE, Han SG. Malignant small bowel neoplasm of enteric plexus derivation (plexosarcoma). Light and electron microscopic study confirming the origin of the neoplasm. Dig Dis Sci 1984;29:275–284 http://dx.doi.org/10.1007/BF01296263[Crossref]
• [2] Herrera GA. Small bowel neoplasm. Dig Dis Sci 1985;30:698 http://dx.doi.org/10.1007/BF01308423[Crossref]
• [3] Lam KY, Law SY, Chu KM, Ma LT. Gastrointestinal autonomic nerve tumor of the esophagus. A clinic opathologic,immunohistochemical, ultrastructural study of a case and review of the literature. Cancer 1996; 78: 1651–1659 http://dx.doi.org/10.1002/(SICI)1097-0142(19961015)78:8<1651::AID-CNCR3>3.0.CO;2-H[Crossref]
• [4] Shek TW, Luk IS, Loong F, Ip P, Ma L. Inflammatory cell-rich gastrointestinal autonomic nerve tumor. An expansion of its histologic spectrum. Am J Surg Pathol 1996; 20: 325–331 http://dx.doi.org/10.1097/00000478-199603000-00009[Crossref]
• [5] Reid I, Suvarna SK, Wagner BE, Rogers K. Plexosarcoma of the bladder. Eur J Surg Oncol 1997; 23: 463–465 http://dx.doi.org/10.1016/S0748-7983(97)93737-9[Crossref]
• [6] Donner LR. Gastrointestinal autonomic nerve tumor: a common type of gastrointestinal stromal neoplasm. Ultrastruct. Pathol 1997; 21: 419–424 http://dx.doi.org/10.3109/01913129709021940[Crossref]
• [7] Erlandson RA, Klimstra DS, Woodruff JM. Subclassification of gastrointestinal stromal tumors based on evaluation by electron microscopy and immunohistochemistry. Ultrastruct Pathol 1996; 20: 373–393 http://dx.doi.org/10.3109/01913129609016340[Crossref]
• [8] Lev D, Kariv Y, Messer GY, Isakov J, Gutman M. Gastrointestinal autonomic nerve (GAN) tumor of the rectum. J Clin Gastroenterol 2000; 30: 438–440 http://dx.doi.org/10.1097/00004836-200006000-00018[Crossref]
• [9] Shek TWH, Luk ISC, Loong F, Ip P, Ma L. Inflammatory cellrich gastrointestinal autonomic nerve tumor: an expansion of its histologic spectrum. Am J Surg Pathol 2003;20:325–331 http://dx.doi.org/10.1097/00000478-199603000-00009[Crossref]
• [10] Hellies R, Sulis R, Puliga A, Pala M, Pietrangeli M. GIST: surgical treatment of34 cases. Tumori 2003;89(4 Suppl): 133–134
• [11] Bucher P, Villiger P, Egger.IF, Bubier LI-I, Morel P. Management of gastrointestinal stromal tumors: from diagnosis to treatment. Swiss Med Wkly 2004;134(11–12):145–153
• [12] Lee JR, Joshi V, Griffin JW Jr, Lasota J, Miettinen M. Gastrointestinal autonomic nerve tumor: immunohistochemical and molecular identity with gastrointestinal stromal tumor. Am J Surg Pathol 2001; 25: 979–987 http://dx.doi.org/10.1097/00000478-200108000-00001[Crossref]
• [13] Kerr JZ, Hicks MJ, Nuchtern GJ, Saldivar V, Hall JH, Shah S et al. Gastrointestinal Autonomic Nerve Tumors in the Pediatric Population. A Report of Four Cases and a Review of the Literature. Cancer January 1999; 85(1): 220–230
• [14] Lauwers GY, Erlandson RA, Casper ES, Brennan MF, Woodruff M. Gastrointestinal autonomic nerve tumors. A clinicopathological,immunohistochemica l, and ultrastructural study of 12 cases. Am J Surg Pathol 1993; 17:887–897 http://dx.doi.org/10.1097/00000478-199309000-00004[Crossref]
• [15] Joensuu H, Fletcher C, Dimitrijevic S, Silberman S, Roberts P, Demetri G. Management of malignant gastrointestinal stromal tumours. Lancet Oncol 2002; 3: 655–664 http://dx.doi.org/10.1016/S1470-2045(02)00899-9[Crossref]
• [16] Bucher P, Villiger P, Egger.IF, Bubier LI-I, Morel P. Management of gastrointestinal stromal tumors: from diagnosis to treatment. Swiss Med Wkly 2004;134(11–12):145–153
• [17] Hellies R, Sulis R, Puliga A, Pala M, Pietrangeli M. GIST: surgical treatment of34 cases. Tumori 2003;89(4 Suppl): 133–134
• [18] Stift A, Friedl J, Gnant M, Herbst F, Jakesz R, Wenzl E. Gastrointestinal autonomic nerve tumors: A surgical point of view. World J Gastroenterol 2004;10(16):2447–2451 [PubMed]

Identyfikatory

DOI

10.2478/s11536-011-0030-4