State of HPV16 integration in Lithuanian women with cervical neoplasia

• Autorzy: Agne Sepetiene , Zivile Gudlevicienė , Zana Bumbuliene , Grazina Drasutiene , Janina Didziapetriene
• Języki publikacji: EN

Abstrakty

EN

Cervical cancer morbidity and mortality in Lithuania is one of the biggest in the European Union. The main risk factor of cervical cancer is human papillomavirus (HPV). The deletion of the HPV E2 gene influences HPV DNA integration into the cell genome, as well as a rapid progression of cervical lesions. The purpose of this study is to determine HPV, its types, and HPV 16 integration in different grades of cervical intraepithelial neoplasias (CIN). 253 women with cytological lesions were involved in the study. After a histology, 31 women were diagnosed with CIN I, 35 with CIN II, and 51 with CIN III. The biggest prevalence of HPV infection was detected in women younger than 25 years old (69.7%) and in women with CIN II (90.9%). HPV 16 was detected in 67.8% of all cases, with the highest prevalence in CIN III (84.4%). A partial integration form was detected in 65.0% of HPV 16 infected women, a complete virus integration in 26.5%, and an episomal form in 8.4% of cases. Our study concludes that in all the cases confirmed using a histology, the partial virus integration form of CIN was identified the most. It was less frequently detected in CIN I cases (60.0%), but more frequently in CIN II and CIN III cases (72.8 and 69.3%, respectively).

Słowa kluczowe

EN

HPV prevalence; HPV 16 integration; Cervical intraepithelial neoplasia

• Czasopismo: Open Medicine
• Rocznik: 2011
• Tom: 6
• Numer: 2
• Strony: 205-212

Daty

wydano

2011-04-01

online

2011-02-17

Twórcy

autor

Agne Sepetiene,

autor

Zivile Gudlevicienė

• Institute of Oncology, Vilnius University, Santariskiu 1, LT-08660, Vilnius, Lithuania

autor

Zana Bumbuliene

autor

Grazina Drasutiene

• Faculty of Medicine, Clinic of Obstetrics and Gynecology, Vilnius University, M.K. Ciurlionio 21, LT-03101, Vilnius, Lithuania

autor

Janina Didziapetriene

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Identyfikatory

DOI

10.2478/s11536-011-0004-6