Hypovitaminosis D and cardiometabolic risk factors among non-obese youth

• Autorzy: Nasser Al-Daghri , Omar Al-Attas , Majed Alokail , Khalid Alkharfy , Mansour Yousef , Hesham Nadhrah , Abdulaziz Al-Othman , Yousef Al-Saleh , Shaun Sabico , George Chrousos
• Języki publikacji: EN

Abstrakty

EN

Hypovitaminosis D and increased cardiometabolic risk have been well established in adults. This study aims to determine whether or not vitamin D also influences cardiometabolic risk in children and adolescents. To test this hypothesis, we recruited 186 boys (mean age 12.4 ± 3.7 years) and 114 girls (11.6 ± 3.7) in a cross-sectional observational study. Anthropometrics were obtained and morning fasting blood samples were collected. Serum glucose and lipid profile were determined using routine methods. Serum 25-hydroxyvitamin D was quantified using an enzyme-linked immunosorbent assay. In our population, approximately 10% of subjects had severe 25-hydroxyvitamin D deficiency (< 12.5 nmol/L), while 50% of the boys and 40% of the girls had mild vitamin D deficiency (12.5–24.9 nmol/L). Circulating 25-hydroxyvitamin D concentrations were inversely correlated with age, body mass index (BMI), blood pressure, waist and hip circumferences and serum triglyceride concentrations, and positively associated with HDL-cholesterol. Age and systolic blood pressure were significant predictors of 25-hydroxyvitamin D, explaining about 30% of the variance (p = 0.0005). In conclusion, significant associations between serum 25-hydroxyvitamin D and cardiometabolic parameters support promising cardioprotective benefits from vitamin D sufficiency at an early age. Follow-up with prospective clinical intervention studies are needed to validate this hypothesis.

Słowa kluczowe

EN

25-Hydroxycholecalciferol; Hypovitaminosis D; Children

• Czasopismo: Open Medicine
• Rocznik: 2010
• Tom: 5
• Numer: 6
• Strony: 752-757

Daty

wydano

2010-12-01

online

2010-10-07

Twórcy

autor

Nasser Al-Daghri

• Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia,

autor

Omar Al-Attas

• Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia

autor

Majed Alokail

• Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia

autor

Khalid Alkharfy

• Clinical Pharmacy Department, College of Pharmacy, King Saud University, 11451, Riyadh, Kingdom of Saudi Arabia

autor

Mansour Yousef

• Health Affairs for Riyadh Region, Ministry of Health, 11176, Riyadh, Kingdom of Saudi Arabia

autor

Hesham Nadhrah

• Health Affairs for Riyadh Region, Ministry of Health, 11176, Riyadh, Kingdom of Saudi Arabia

autor

Abdulaziz Al-Othman

• College of Applied Medical Sciences, King Saud University, 11451, Riyadh, Kingdom of Saudi Arabia

autor

Yousef Al-Saleh

• King Abdulaziz Medical City, 11426, Riyadh, Kingdom of Saudi Arabia

autor

Shaun Sabico

• Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Riyadh, Kingdom of Saudi Arabia

autor

George Chrousos

Bibliografia

• [1] Molina J.A., Heng B.H., Global trends in cardiology and cardiothoracic surgery - an opportunity or a threat?, Ann. Acad. Med. Singapore 2009, 38, 541–545
• [2] Al-Nozha M.M., Abdullah M., Arafah M.R., Khalil M.Z., Khan N.B., Al-Mazrou Y.Y., et al., Hypertension in Saudi Arabia, Saudi Med. J. 2007, 28,77–84
• [3] Al-Nozha M.M., Arafah M.R., Al-Maatouq M.A., Khalil M.Z., Khan N.B., Al-Marzouki K., et al., Hyperlipidemia in Saudi Arabia, Saudi Med. J. 2008, 29, 282–287
• [4] Al-Nozha M., Al-Khadra A., Arafah M.R., Al-Maatouq M.A., Khalil M.Z., Khan N.B., et al., Metabolic syndrome in Saudi Arabia, Saudi Med. J. 2005, 26, 1918–1925
• [5] El-Mouzan M.I., Al-Herbish A., Al-Salloum A.A., Al-Omar A.A., Qurachi M.M., Trends in the nutritional status of Saudi children, Saudi Med. J. 2008, 29, 884–887 [PubMed]
• [6] Al-Hazzaa H.M., Prevalence of physical inactivity in Saudi Arabia: a brief review, East Mediterr. Health J. 2004, 10, 663–670
• [7] Bawazeer N., Al-Daghri N., Valsamakis G., Al-Rubeaan K., Valsamakis G, Sabico S., et al., Sleep duration and quality associated with obesity among Arab children, Obesity 2009, 17, 2251–2253 http://dx.doi.org/10.1038/oby.2009.169[Crossref]
• [8] Camhi S.M., Katzmarzyk P.T., Tracking of cardiometabolic risk factor clustering from childhood to adulthood, Int. J. Pediatr. Obes. 2009, 1–8 [Crossref]
• [9] Jiang S., Bao Y., Hou X., Fang O., Wang C., Pan J., et al., Serum C-reactive protein and risk of cardiovascular events in middle-aged and older Chinese population, Am. J. Cardiol. 2009, 103, 1727–1731 http://dx.doi.org/10.1016/j.amjcard.2009.02.028[Crossref]
• [10] Zhou J., Austin R.C., Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms, Biofactors 2009, 35, 120–129 http://dx.doi.org/10.1002/biof.17[WoS][Crossref]
• [11] Mithal A., Wahl D.A., Bonjour J.P., Burckhardt P., Dawson-Hughes B., Eisman J.A., et al., Global vitamin D status and determinants of hypovitaminosis D, Osteoporosis Int. 2009, 20, 1807–1820 http://dx.doi.org/10.1007/s00198-009-0954-6[WoS][Crossref]
• [12] Judd S.E., Tangpricha V., Vitamin D deficiency and risk of cardiovascular disease, Am. J. Med. Sci. 2009, 338, 40–44 http://dx.doi.org/10.1097/MAJ.0b013e3181aaee91[Crossref]
• [13] Forouhi N.G., Luan J., Cooper A., Boucher B.J., Wareham N.J., Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990–2000, Diabetes 2008, 57, 2619–2625 http://dx.doi.org/10.2337/db08-0593[WoS]
• [14] Moradzadeh K., Larijani B., Keshtar A., Hossein-Nezhad A., Rajabian R., Nabipour I., et al., Normative values of vitamin D among Iranian population: a population based study, Int. J. Osteoporosis Metabolic Disorders 2008, 1, 8–15 http://dx.doi.org/10.3923/ijom.2008.8.15[Crossref]
• [15] Rovner A.J., O’Brien K.O., Hypovitaminosis D among healthy children in the United States, Arch. Pediatr. Adolesc. Med. 2008, 162, 513–519 http://dx.doi.org/10.1001/archpedi.162.6.513[Crossref]
• [16] Bener A., Al-Ali M., Hoffman G.F., High prevalence of vitamin D deficiency in young children in a highly sunny humid country: a global health problem, Minerva Pediatr. 2009, 61, 15–22
• [17] Sedrani S.H., Elidrissy A.W., El Arabi K.M., Sunlight and vitamin D status in normal Saudi subjects, Am. J. Clin. Nutr. 1983, 38, 129–132
• [18] Al-Atawi M.S., Al-Alwan I.A., Al-Mutair A.N., Tanim H.M., Al-Jurayyan N.A., Epidemiology of nutritional rickets in children, Saudi J. Kidney Dis. Transpl. 2009, 20, 260–265
• [19] McCarty M.F., Poor vitamin D status may contribute to high risk for insulin resistance, obesity and cardiovascular disease in Asian Indians, Med. Hypotheses 2009, 72, 647–651 http://dx.doi.org/10.1016/j.mehy.2008.12.031[Crossref][WoS]
• [20] Nemerovski C.W., Dorsch M.P., Simpson R.U., Bone H.G., Aaronson K.D., Bleske B.E., Vitamin D and cardiovascular disease, Pharmacotherapy 2009, 29, 691–708 http://dx.doi.org/10.1592/phco.29.6.691[Crossref][WoS]
• [21] Matias P.J., Ferreira C., Jorge C., Borges M., Aires I., Amaral T., 25-Hydroxyvitamin D3, arterial calcifications and cardiovascular risk markers in haemodialysis patients, Nephrol. Dial. Transplant 2009, 24, 611–618 http://dx.doi.org/10.1093/ndt/gfn502[Crossref]
• [22] Alemzadeh R., Kichler J., Babar G., Calhoun M., Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity and season, Metabolism 2008, 57, 183–191 http://dx.doi.org/10.1016/j.metabol.2007.08.023[Crossref]
• [23] Gannage-Yared M.H., Chedid R., Khalife S., Azzi E., Zoghbi F., Halaby G., Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population, Eur. J. Endocrinol. 2009, 160, 965–971 http://dx.doi.org/10.1530/EJE-08-0952[Crossref]
• [24] Forman J.P., Giovannucci E., Holmes M.D., Bischoff-Ferrari H.A., Tworoger S.S., Willett W.C., et al., Plasma 25-hydroxyvitamin D levels and risk of incident hypertension, Hypertension 2007, 49, 1063–1069 http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.087288[Crossref]
• [25] Hsia J., Heiss G., Ren H., Allison M., Dolan N.C., Greenland P., et al., Calcium/vitamin D supplementation and cardiovascular events, Circulation 2007, 115, 846–854 http://dx.doi.org/10.1161/CIRCULATIONAHA.106.673491[Crossref]

Identyfikatory

DOI

10.2478/s11536-010-0045-2