Mental retardation and consanguinity in a selected region of the Israeli Arab community

• Autorzy: Rajach Sharkia , Abdussalam Azem , Qassem Kaiyal , Nathanel Zelnik , Muhammad Mahajnah
• Języki publikacji: EN

Abstrakty

EN

The prevalence of genetic diseases and congenital malformation in the Israeli Arab community is relatively high, but its distribution is not uniform. The aim of this study was to estimate the frequency of mental retardation disorders in children living in 5 Israeli Arab villages and determine its association with consanguinity. Mental retardation was found to affect 300 children in the screened population, yielding an overall prevalence of 14.5 per 1000. Most of those affected (68%) were the offspring of consanguineous marriages. One village with a high prevalence (4.3%) of neurological hereditary diseases was studied in detail. The prevalence of neurological hereditary diseases and mental retardation associated with consanguinity in these children highlights the need to implement appropriate preventive program.

Słowa kluczowe

EN

Mental Retardation; Consanguinity; Hereditary diseases

• Czasopismo: Open Medicine
• Rocznik: 2010
• Tom: 5
• Numer: 1
• Strony: 91-96

Daty

wydano

2010-02-01

online

2010-01-29

Twórcy

autor

Rajach Sharkia,

autor

Abdussalam Azem

• Department of Biochemistry, Faculty of Life Sciences, Tel-Aviv University, 69978, Tel-Aviv, Israel

autor

Qassem Kaiyal

• Rappaport Faculty of Medicine, Technion, Child Neurology and Development Center, Carmel Medical Center, 31096, Haifa, Israel

autor

Nathanel Zelnik

• Rappaport Faculty of Medicine, Technion, Child Neurology and Development Center, Carmel Medical Center, 31096, Haifa, Israel

autor

Muhammad Mahajnah

• Rappaport Faculty of Medicine, Technion, Child Neurology and Development Center, Carmel Medical Center, 31096, Haifa, Israel

Bibliografia

• [1] Zlotogora J., Genetic disorders among Palestinian Arabs: 1. Effects of consanguinity, Am. J. Med. Genet., 1997, 68, 472–475 http://dx.doi.org/10.1002/(SICI)1096-8628(19970211)68:4<472::AID-AJMG20>3.0.CO;2-O[Crossref]
• [2] Bener A., Hussain R., Teebi A.S., Consanguineous marriages and their effects on common adult diseases: studies from an endogamous population, Med. Princ. Pract., 2007, 16, 262–267 http://dx.doi.org/10.1159/000102147[WoS][Crossref]
• [3] Teebi A.S., Teebi S.A., Genetic diversity among the Arabs, Community Genet., 2005, 8, 21–26 http://dx.doi.org/10.1159/000083333[Crossref]
• [4] Jaber L., Merlob P., Bu X., Rotter J.I., Shohat M., Marked parental consanguinity as a cause for increased major malformations in an Israeli Arab community, Am. J. Med. Genet., 1992, 44, 1–6 http://dx.doi.org/10.1002/ajmg.1320440102[Crossref]
• [5] Zlotogora J., Haklai Z., Rotem N., Georgi M., Berlovitz I., Leventhal A., Amitai, Y., Relative prevalence of malformations at birth among different religious communities in Israel, Am. J. Med. Genet., A, 2003, 122, 59–62 http://dx.doi.org/10.1002/ajmg.a.20229[Crossref]
• [6] Sharkia R., Zaid M., Athamna A., Cohen D., Azem A., Zalan A., The changing pattern of consanguinity in a selected region of the Israeli Arab community, Am. J. Hum. Biol., 2008, 20, 72–77 http://dx.doi.org/10.1002/ajhb.20678[Crossref][WoS]
• [7] Zlotogora J., Molecular basis of autosomal recessive diseases among the Palestinian Arabs, Am. J. Med. Genet., 2002, 109, 176–182 http://dx.doi.org/10.1002/ajmg.10328[Crossref]
• [8] Mental Retardation: Classification and Systems of Supports, American Association on Mental retardation, 2002, 10th edn, Washington.
• [9] McLaren J., Bryson S.E., Review of recent epidemiological studies of mental retardation: prevalence, associated disorders, and etiology, Am. J. Ment. Retard., 1987, 92, 243–254
• [10] Ropers H.H., Hamel B.C., X-linked mental retardation, Nat. Rev. Genet., 2005, 6, 46–57 http://dx.doi.org/10.1038/nrg1501[Crossref]
• [11] Kleefstra T., Hamel B.C., X-linked mental retardation: further lumping, splitting and emerging phenotypes, Clin. Genet., 2005, 67, 451–467 http://dx.doi.org/10.1111/j.1399-0004.2005.00434.x[Crossref]
• [12] Basel-Vanagaite L., Attia R., Yahav M., Ferland R.J., Anteki L., Walsh C. K., et al., The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation, J. Med. Genet., 2005, 43, 203–210 http://dx.doi.org/10.1136/jmg.2005.035709[Crossref]
• [13] Santos C., Rodriguez-Revenga L., Madrigal I., Badenas, C., Pineda M., Mila M., A novel mutation in JARID1C gene associated with mental retardation, Eur. J. Hum. Genet., 2006, 14, 583–586 http://dx.doi.org/10.1038/sj.ejhg.5201608[Crossref]
• [14] Basel-Vanagaite L., Taub E., Halpern G.J., Drasinover V., Magal N., Davidov B., et al., Genetic screening for autosomal recessive nonsyndromic mental retardation in an isolated population in Israel, Eur. J. Hum. Genet., 2007, 15, 250–253 http://dx.doi.org/10.1038/sj.ejhg.5201750[Crossref][WoS]
• [15] Uyguner O., Kayserili H., Li Y., Karaman B., Nurnberg G., Hennies H. C., et al., A new locus for autosomal recessive non-syndromic mental retardation maps to 1p21.1–p13.3, Clin. Genet., 2007, 71, 212–219 http://dx.doi.org/10.1111/j.1399-0004.2007.00762.x[Crossref]
• [16] Stromme P., Valvatne K., Mental retardation in Norway: prevalence and sub-classification in a cohort of 30037 children born between 1980 and 1985, Acta. Paediatr. 1998, 87, 291–296 http://dx.doi.org/10.1080/08035259850157345
• [17] Durkin M.S., Hasan Z.M., Hasan K.Z., Prevalence and correlates of mental retardation among children in Karachi, Pakistan, Am. J. Epidemiol. 1998, 147, 281–288 [Crossref]
• [18] Kiely M., The prevalence of mental retardation, Epidemiol. Rev., 1987, 9, 194–218
• [19] Jaber L., Halpern G.J., Shohat T., Trends in the frequencies of consanguineous marriages in the Israeli Arab community, Clin. Genet., 2000, 58, 106–110 http://dx.doi.org/10.1034/j.1399-0004.2000.580203.x[Crossref]

Identyfikatory

DOI

10.2478/s11536-009-0112-8