IgA Myeloma and Still’s Disease in a patient with bilateral silicone breast implants

• Autorzy: Punit Yadav , Iwona Ordyniec , Salem Madi
• Języki publikacji: EN

Abstrakty

EN

We report a case of a woman with bilateral silicone breast implants who presented with recurrent high grade fever, joint and muscle aches. An extensive workup failed to indicate an infectious source of her illness, so based on her symptoms a clinical diagnosis of Adult Onset Still’s disease was made. However, subsequent investigations revealed raised IgA paraprotein levels in her serum which led to a bone marrow examination. Bone marrow examination was consistent with IgA Myeloma. Chemotherapy was commenced which led to a decrease in the paraprotein level. In addition, she was treated with non steroidal anti-inflammatory drugs and intraarticular steroid injections which provided marked symptomatic relief. The case indicates a possible association of Myeloma and Adult Onset Still’s Disease in a patient with bilateral silicone breast implant.

Słowa kluczowe

EN

Silicone; Breast implants; Myeloma; Adult Onset Still’s Disease; Antigenic stimulation

• Czasopismo: Open Medicine
• Rocznik: 2008
• Tom: 3
• Numer: 2
• Strony: 229-231

Daty

wydano

2008-06-01

online

2008-04-09

Twórcy

autor

Punit Yadav

• Staffordshire General Hospital, ST16 3SA, Stafford, United Kingdom,

autor

Iwona Ordyniec

• Royal Albert Edward Infirmary, WN1 2NN, Wigan, United Kingdom

autor

Salem Madi

• Royal Albert Edward Infirmary, WN1 2NN, Wigan, United Kingdom

Bibliografia

• [1] Jenkins M.E., Friedman H.I., von Recum A.F., Breast Implants: Facts, Controversy, and Speculations for Future Research, J. Invest. Surg., 1996, 9, 1–12 http://dx.doi.org/10.3109/08941939609012455[Crossref]
• [2] Pasqualetti P., Collacciani A., Casale R., Risk of monoclonal gammopathy of undetermined significance: A case-referent study, Am. J. Hemat., 1996, 52, 217–20 http://dx.doi.org/10.1002/(SICI)1096-8652(199607)52:3<217::AID-AJH15>3.0.CO;2-C[Crossref]
• [3] Vojdani A., Campbell A., Brautbar N., Immune functional impairment in patients with clinical abnormalities and silicone breast implants, Toxicol. Industr. Health, 1992, 8, 415–29
• [4] Potter M., Morrison S., Wiener F., Zhang X.K., Miller F.W., Induction of plasmacytomas with silicone gel in genetically susceptible strains of mice, J Nat. Cancer Institute, 1994, 86, 1058–65 http://dx.doi.org/10.1093/jnci/86.14.1058[Crossref]
• [5] Efthimiou P., Kontzias A., Ward C.M., Ogden N.S., Adult-onset Still’s disease: can recent advances in our understanding of its pathogenesis lead to targeted therapy? Nature Clin. Pract. Rheumatol., 2007, 3, 328–35 http://dx.doi.org/10.1038/ncprheum0510[Crossref][WoS]
• [6] Yoshida S.H., Teuber S.S., German J.B., Gershwin M.E., Immunotoxicity of silicone: implications of oxidant balance towards adjuvant activity, Food Chem. Toxicol., 1994, 32, 1089–100 http://dx.doi.org/10.1016/0278-6915(94)90150-3[Crossref]
• [7] Surgical implants and other foreign bodies, IARC monograph on the evaluation of carcinogenic risks to humans. International agency for research on cancer. Volume 74, Lyon (France), IARC Press, 1999

Identyfikatory

DOI

10.2478/s11536-008-0025-y