Czasopismo
Tytuł artykułu
Autorzy
Warianty tytułu
Języki publikacji
Abstrakty
Insulin-like growth factor type 1 (IGF-1) belongs to the peptide hormones which regulate cell proliferation and differentiation as well as angiogenesis. The aim of the present study was the quantitative evaluation of immuohistochemical (IH) expression of IGF-1 and its two receptors (IGF-1Rα and IGF-1Rβ) parallel to changes of capillary lumen/whole capillary area (L/W) ratio during the perinatal period. Tissue samples from lungs from 19-, and 21-day fetuses as well as 1-, 3-, 5-day old newborns were processed for frozen sections that were used for IH staining and then used for quantitative analysis of antigens expression. In parallel, tissue samples were processed for transmission electron microscopy and used for capillaries morphometry. Our results were statistically evaluated. We found that the expression of IGF-1 in the peripheral part of the developing lung has a peak at the moment of birth when changes of vascular structure were reflected by L/W ratio. This is followed by the peak expression of the IGF-1Rα, but not of the IGF-1Rβ.
Czasopismo
Rocznik
Tom
Numer
Strony
2-11
Opis fizyczny
Daty
wydano
2006-03-01
online
2006-03-01
Twórcy
autor
- Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60-355, Poznan, Poland, amars@amp.edu.pl
autor
- Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60-355, Poznan, Poland
autor
- Department of Pathology, Oita Medical University, Oita, Japan
autor
- Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60-355, Poznan, Poland
autor
- Intensive Care Unit, Collegium Medicum Jagiellonian University, Kraków, Poland
autor
- Department of Pathology, Oita Medical University, Oita, Japan
Bibliografia
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- [4] A. Hellstrom, C. Perruzzi, M. Ju, E. Engstrom, A.L. Hard, J.L. Liu, K. Albertsson-Wikland, B. Carlsson, A. Niklasson, L. Sjodell, D. LeRoith, D.R. Senger and L.E. Smith: “Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity”, P. Natl. Acad. Sci. USA Vol. 98, (2001), pp. 5804–5808. http://dx.doi.org/10.1073/pnas.101113998[Crossref]
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- [6] A. Marszalek, M. Wasowicz and W. Biczysko: “Quantitative morphometry - an easy and inexpensive method for comparative studies of antigen expression during development”, Folia Histochem. Cyto., Vol. 39, (2001), pp. 199–200.
- [7] P.D. Kohlberger, F. Breitenecker, A. Kaider, A. Losch, G. Gitsch, G. Breitenecker and D.G. Kieback: “Modified true-color computer-assisted image analysis versus subjective scoring of estrogen receptor expression in breast cancer: a comparison”, Anticancer Res. Vol. 19, (1999), pp. 2189–2194.
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- [9] W.G. Guntheroth, D.L. Luchtel and I. Kawabori: “Functional implications of the pulmonary microcirculation. An update”, Chest Vol. 101, (1992), pp. 1131–1134.
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- [11] L.D. Wallen, W. Myint, K. Nygard, S. Shimasaki, D.R. Clemmons and V.K.M. Han: “Cellular distribution of insulin-like growth factor binding protein mRNA and peptides during rat lung development”, J. Endocrinol. Vol. 155, (1997), pp. 313–327. http://dx.doi.org/10.1677/joe.0.1550313[Crossref]
- [12] A. Marszalek, T. Daa, K. Kashima, I. Nakayama and S. Yokoyama: “Expression of vascular endothelial growth factor and its receptors in the developing rat lung”, Jpn. J. Physiol. Vol. 51, (2001), pp. 313–318. http://dx.doi.org/10.2170/jjphysiol.51.313[Crossref]
- [13] S. Buch, R.N. Han, J. Cabacungan, J. Wang, S. Yuan, R. Belcastro, J. Deimling, R. Jankov, X. Luo, S.J. Lye, M. Post and A.K. Tanswell: “Changes in expression of platelet-derived growth factor and its receptors in the lungs of newborn rats exposed to air or 60 % O(2)”, Pediatr. Res. Vol. 48, (2000), pp. 423–433.
- [14] A.C.C. Frasch, M.E. Itoiz and R.L. Cabrini: “Microspectrofotometric quantitation of the diaminobenzidine reaction for histochemical demonstration of cytochrome oxidase activity”, J. Histochem. Cytochem. Vol. 26, (1978), pp. 157–162.
Typ dokumentu
Bibliografia
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bwmeta1.element.-psjd-doi-10_2478_s11536-006-0003-1