MCNP simulation of the dose distribution in liver cancer treatment for BNC therapy

• Autorzy: Dragana Krstic , Zoran Jovanovic , Vladimir Markovic , Dragoslav Nikezic , Vlade Urosevic
• Języki publikacji: EN

Abstrakty

EN

The Boron Neutron Capture Therapy (BNCT) is based on selective uptake of boron in tumour tissue compared to the surrounding normal tissue. Infusion of compounds with boron is followed by irradiation with neutrons. Neutron capture on 10B, which gives rise to an alpha particle and recoiled 7Li ion, enables the therapeutic dose to be delivered to tumour tissue while healthy tissue can be spared. Here, therapeutic abilities of BNCT were studied for possible treatment of liver cancer using thermal and epithermal neutron beam. For neutron transport MCNP software was used and doses in organs of interest in ORNL phantom were evaluated. Phantom organs were filled with voxels in order to obtain depth-dose distributions in them. The result suggests that BNCT using an epithermal neutron beam could be applied for liver cancer treatment.

Słowa kluczowe

EN

Boron Neutron Capture Therapy (BNCT); Monte Carlo simulation; depth-dose distributions; liver cancer

• Czasopismo: Open Physics
• Rocznik: 2014
• Tom: 12
• Numer: 10
• Strony: 714-718

Daty

wydano

2014-10-01

online

2014-08-16

Twórcy

autor

Dragana Krstic

• Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia,

autor

Zoran Jovanovic

• Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia

autor

Vladimir Markovic

• Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia

autor

Dragoslav Nikezic

• Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia

autor

Vlade Urosevic

• Faculty of Technical Science, University of Kragujevac, Svetog Save 65, 32000, Cacak, Serbia

Bibliografia

• [1] D. L. Bleuel, W. T. Chu, R. J. Donahue, B. A. Ludewigta, J. Vujic, Med. Phys. 25, 1725 (1998) http://dx.doi.org/10.1118/1.598353[Crossref]
• [2] F. El Moussaoui, T. El Bardouni, M. Azahra, A. Kamili, H. Boukhal, Cancer/Radiotherapie 12, 360 (2008) http://dx.doi.org/10.1016/j.canrad.2008.03.005[Crossref]
• [3] A. Zonta et al., Appl. Radiat. Isot. 67, S67 (2009) http://dx.doi.org/10.1016/j.apradiso.2009.03.087[Crossref]
• [4] G. Gambarini, G. G. Daquino, R. L. Moss, M. Carrara, V. A. Nievaart, E. Vanossi, Radiat. Prot. Dosim. 126, 604 (2007) http://dx.doi.org/10.1093/rpd/ncm123[Crossref]
• [5] T. Pinelli et al., Eighth International Symposium, 1998, Los Angeles, CA, USA (Kluwer Academic/Plenum Publishers, New York, 2001) 1427
• [6] A. Zonta et al., J. Phys.: Conference Series 41, 484 (2006) http://dx.doi.org/10.1088/1742-6596/41/1/054[Crossref]
• [7] S. Bortolussi et al., Appl. Radiat. Isot. 69, 1924 (2011) http://dx.doi.org/10.1016/j.apradiso.2011.03.034[Crossref]
• [8] L. Kankaanranta et al., Int. J. Radiation Oncol. Biol. Phys. 69, 475 (2007) http://dx.doi.org/10.1016/j.ijrobp.2007.03.039[Crossref]
• [9] I. Porras, Phys. Med. Biol. 57, L1 (2008) http://dx.doi.org/10.1088/0031-9155/53/7/L01[Crossref]
• [10] I. Porras, Appl. Radiat. Isot. 69, 1838 (2011) http://dx.doi.org/10.1016/j.apradiso.2011.04.002[Crossref]
• [11] H. Horiguchi, T. Nakamura, H. Kumada, H. Yanagie, M. Suzuki, H. Sagawa, Appl. Radiat. Isot. 69, 1882 (2011) http://dx.doi.org/10.1016/j.apradiso.2011.03.036[Crossref]
• [12] D. Krstic, V. M. Markovic, Z. Jovanovic, B. Milenkovic, D. Nikezic, J. Atanackovic, Radiat. Prot. Dosim. DOI:10.1093/rpd/nct365. [Crossref]
• [13] K. F. Eckerman, M. Cristy, J. C. Ryman The ORNL Mathematical Phantom Series, Oak Ridge National Laboratory Report, (Oak Ridge, TN, USA, 1996) Updated 08 April (2009)
• [14] D. Krstic, D. Nikezic, Comp. Phys. Commun. 176, 33 (2007) http://dx.doi.org/10.1016/j.cpc.2006.06.016[Crossref]
• [15] X-5 Monte Carlo Team, MCNP’a General Monte Carlo N-Particle Transport Code, Version 5 Vol. I: Overview and Theory (Los Alamos National Laboratory, Los Alamos, 2003)
• [16] T. Matsumoto, Nucl. Instrum. Meth. A 580, 552 (2007) http://dx.doi.org/10.1016/j.nima.2007.05.233[Crossref]

Identyfikatory

DOI

10.2478/s11534-014-0507-2