Complexes of platinum and palladium with 4-nitrobenzoic hydrazide: synthesis and cytotoxic activity

• Autorzy: Gustavo Souza , Mônica Rodrigues , Lucianno Fernandes , Priscila Silva , Reinaldo Ruggiero , Elene Pereira-Maia , Wendell Guerra
• Języki publikacji: EN

Abstrakty

EN

New complexes of platinum and palladium were isolated with 4-nitrobenzoic hydrazide (4-NH) and characterized by spectroscopic techniques. Results show that the ligand is coordinated to metallic ions by the basic nitrogen of NH2 group and have the general structure cis-[M(4-NH)2X2] where M= Pt or Pd and x = Cl or I. The compound III, [Pt(4-NH)2I2], was found to display cytotoxicity (IC50 = 0.96 µmol L−1) against the K562 tumoral cell line. This complex is significantly more cytotoxic than cisplatin. [...]

Słowa kluczowe

EN

Platinum complexes; Palladium complexes; Hydrazones; Cytotoxic activity

• Czasopismo: Open Chemistry
• Rocznik: 2013
• Tom: 11
• Numer: 2
• Strony: 290-294

Daty

wydano

2013-02-01

online

2012-11-29

Twórcy

autor

Gustavo Souza

• Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil

autor

Mônica Rodrigues

• Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil

autor

Lucianno Fernandes

• Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil

autor

Priscila Silva

• Chemistry Department, Federal University of Minas Gerais, Campus Pampulha, 31, 270-901, Belo Horizonte — MG, Brazil

autor

Reinaldo Ruggiero

• Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil

autor

Elene Pereira-Maia

• Chemistry Department, Federal University of Minas Gerais, Campus Pampulha, 31, 270-901, Belo Horizonte — MG, Brazil

autor

Wendell Guerra

• Chemistry Institute, Federal University of Uberlândia, Campus Santa Mônica, 38, 400-902, Uberlândia — MG, Brazil,

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Identyfikatory

DOI

10.2478/s11532-012-0156-5