Synthesis, characterization and antifungal testing of 3,4-dihydropyrimidin-2(1H)-(thio)ones containing boronic acids and boronate esters

• Autorzy: Dominique Duguay , Matthew Zamora , Johanna Blacquiere , Francis Appoh , Christopher Vogels , Susan Wheaton , Felix Baerlocher , Andreas Decken , Stephen Westcott
• Języki publikacji: EN

Abstrakty

EN

The addition of formylphenylboronic acid derivatives to thiourea and ethyl acetoacetate proceeds in the presence of an additional Lewis acid catalyst to give the corresponding 3,4-dihydropyrimidin-2(1H)-(thio)ones (Biginelli products) in moderate yield. Compounds were tested for antifungal activity against pure cultures of Aspergillus niger, Aspergillus flavus, Candida albicans and Saccharomyces cerevisiae but, unfortunately, none showed any appreciable activity. [...]

Słowa kluczowe

EN

Antifungal; Biginelli compounds; Boron; 3,4-dihydropyrimidin-2(1H)-(thio)ones; Monastrol

• Czasopismo: Open Chemistry
• Rocznik: 2008
• Tom: 6
• Numer: 4
• Strony: 562-568

Daty

wydano

2008-12-01

online

2008-10-28

Twórcy

autor

Dominique Duguay

• Department of Chemistry, Mount Allison University, Sackville, NB, E4L 1G8, Canada

autor

Matthew Zamora

• Department of Chemistry, Mount Allison University, Sackville, NB, E4L 1G8, Canada

autor

Johanna Blacquiere

• Department of Chemistry, Mount Allison University, Sackville, NB, E4L 1G8, Canada

autor

Francis Appoh

• Department of Chemistry, Mount Allison University, Sackville, NB, E4L 1G8, Canada

autor

Christopher Vogels

• Department of Chemistry, Mount Allison University, Sackville, NB, E4L 1G8, Canada

autor

Susan Wheaton

• Department of Chemistry, Mount Allison University, Sackville, NB, E4L 1G8, Canada

autor

Felix Baerlocher

• Department of Biology, Mount Allison University, Sackville, NB, E4L 1G7, Canada

autor

Andreas Decken

• Department of Chemistry, University of New Brunswick, Fredericton, NB, E3B 5A3, Canada

autor

Stephen Westcott

• Department of Chemistry, Mount Allison University, Sackville, NB, E4L 1G8, Canada,

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Identyfikatory

DOI

10.2478/s11532-008-0064-x