Voltammetric quantitation at the mercury electrode of the anticholinergic drug flavoxate hydrochloride in bulk and in a pharmaceutical formulation

• Autorzy: M.M. Ghoneim , M.A. El-Attar , S.A. Razeq
• Języki publikacji: EN

Abstrakty

EN

Flavoxate hydrochloride, 2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4-H-chromene-8-carboxylate, is a smooth muscle antispasmodic. Its electrochemical behavior was studied at the mercury electrode in buffered solutions containing 30% (v/v) methanol using dc-polarography, differential-pulse polarography, cyclic voltammetry, and linear sweep-and square-wave adsorptive stripping voltammetry. Sensitive and precise procedures were developed for determination of bulk flavoxate hydrochloride and in the pharmaceutical formulation Genurin® S.F, without sample pretreatment or extraction. Limits of quantitation (LOQ) of 1 × 10−5, 5 × 10−6, 1 × 10−8 and 1 × 10−9 M flavoxate hydrochloride were achieved by dc-polarography, differential-pulse polarography, linear sweep and square-wave adsorptive stripping voltammetric, respectively. [...]

Słowa kluczowe

EN

Flavoxate hydrochloride; Genurin® tablets; polarography; cyclic voltammetry; adsorptive stripping voltammetry; quantitation

• Czasopismo: Open Chemistry
• Rocznik: 2007
• Tom: 5
• Numer: 2
• Strony: 496-507

Daty

wydano

2007-06-01

online

2007-02-02

Twórcy

autor

M.M. Ghoneim

• Analytical Chemistry Research Unit, Chemistry Department, Faculty of Science, Tanta University, 31527, Tanta, Egypt,

autor

M.A. El-Attar

• Analytical Chemistry Research Unit, Chemistry Department, Faculty of Science, Tanta University, 31527, Tanta, Egypt

autor

S.A. Razeq

• Department of Analytical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, 11754, Nacer City-Cairo, Egypt

Bibliografia

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Identyfikatory

DOI

10.2478/s11532-007-0011-2