Mechanism and Effects of Cyanobacterial Hepatotoxin Action on Human Organism

• Autorzy: Aleksandra Zyska , Jolanta Jasik-Ślęzak
• Języki publikacji: EN

Abstrakty

EN

Eutrophication of waters and climate warming have created in the last decades favourable conditions for cyanobacteria colonization. The presence of cyanobacteria toxins in heavily polluted lake waters and fish ponds has become a current problem. These toxins belong to cyanobacteria secondary metabolites and are active in various fields of harmfulness to animals and humans. This group includes neurotoxins, dermatotoxins and hepatotoxins having a destructive influence on liver's cells. The group of hepatotoxins comprises microcystins and nodularin. The symptoms of hepatotoxin poisoning include stomach, intestine and liver disorders, intra-liver bleeding and physiological insufficiency of this organ. These compounds can induce apoptosis of liver cells and tumor promoters. From the above facts, it follows that hepatotox-ins can pose a very serious health problem on a global scale. This work presents the characteristic of cyanobacterial hepato-toxins, their chemical structure, properties, and mechanism of their action on human organism. The harmful influence caused by consuming products used in diet supplements, which contain microcystins was also pointed out.

Słowa kluczowe

EN

cyanobacteria; cyanobacterial hepatotoxins; toxic action mechanism

• Czasopismo: Polish Journal of Public Health
• Rocznik: 2015
• Tom: 124
• Numer: 3
• Strony: 156-159

Daty

online

2014-12-10

Twórcy

autor

Aleksandra Zyska

• Chair of Public Health, Technical University in Częstochowa, Poland,

autor

Jolanta Jasik-Ślęzak

• Chair of Public Health, Technical University in Częstochowa, Poland

Bibliografia

• 1. Briand JF, Jacquet S, Bernard C, Humbert JF. Health hazards for terrestrial vertebrates from toxic cyanobacteria in surfaces water ecosystems. Vet Res. 2003;34:361-7.[Crossref]
• 2. Seckbach J. Alge and cyanobacteria in extreme environments. Holandia: Springer, Dordrecht; 2007. p. 661-83.
• 3. Christiansen G, Molitor C, Philmus B, Kurmayer R. Nontoxic strains of cyanobacteria are the result of major gene deletion events induced by a transposable element. Mol Biol Evol. 2008;25:1695-704.[PubMed][Crossref][WoS]
• 4. Mazur-Marzec H, Borowczyk-Matusiak G, Forycka K, et al. Morfologi-cal, genetic, chemical and ecophysiological characterisation of two Mi-crocystis aeruginosa isolates from the Vistula Lagoon, southern Baltic. Oceanol. 2010;52:127-56.[Crossref]
• 5. Rogalska-Kupiec M, Bochnia T. Toksyny syntetyzowane przez sinice. Wiad Bot. 1998;42:11-9.
• 6. Codd G, Morrison LF, Metcalf JS. Cyanobacterial toxins: risk management for health protection. Toxicol. Appl Pharmacol. 2005;203:264-72.
• 7. Del Campo FF, Ouahid Y. Identyfication of microcystins from three col-lectoin strains of Microcystis aeruginosa. Environ Poll. 2010;158:2906-14.[Crossref]
• 8. Namikoshi M, Rinehart K L, Sakai R, et al. Structures of three new cyclic heptapeptide hepatotoxins produced by the cyanobacterium (blue-green alga) Nostoc sp. J Org Chem. 1990;55:6135-9.[Crossref]
• 9. Humpage A. Toxin types, toxicokinetics and toxicodynamics. Adv Exp Med Biol. 2008;619:383-415.
• 10. Chorus I, Falconer IR, Salas HJ, Bartram J. Health risks caused by freshwater cyanobacteria in recreational waters. J Toxicol Environ. Health Part B. 2000;3:323-47.
• 11. El-Shehawy R, Gorokhova E, Fernández-Piñas F, del Campo FF. Global warming and hepatotoxin production by cyanobacteria: What can we learn from experiments? Water Res. 2012;46:1420-9.[WoS]
• 12. Rinehart KL, Namikoshi M, Choi BW. Structure and Biosynthesis of toxins from blue-green algae (cyanobacteria). J Appl Physiol. 1994;6:159-76.
• 13. Botes DP, Kruger H, Viljoen CC. Isolation and characterisation of four toxins from the blue green alga Microcystis aeruginosa. Toxicon. 1982a;20:945-54.[Crossref]
• 14. Eriksson JE, Toivola D, Meriluo'o JAO, et al. Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphst-sses. Biochem Biophys Res Commun. 1990;173:1347-53.
• 15. Sivonen K. Cyanobacterial toxins and toxin production. Phycol. 1996;35:12-24.[Crossref]
• 16. Carmichael WW. Health effects of toxin-producing cyanobacteria, The Cyano Habs Hum Ecol Risk. Assessement. 2001;7:1393-407.[Crossref]
• 17. Dawson RM. The toxicology of microcystins. Toxicon. 1998;36:953-62[Crossref][PubMed]
• 18. Pearson LA, Neilan BA. The molecular genetics of cyanobacterial toxicity as a basis for monitoring water qality and public health risk. Cur Opin Biotech.2008;19:281-8.[Crossref]
• 19. Walker M, von Dohren H. Cyanobacterial peptides – nature's own combinatorial biosynthesis. FEMS Microbiol Rev. 2006;30:530-63.[Crossref]
• 20. Ding W-X, Shen H-M, Ong C-N. Microcystic cyanobacteria extract induces cytoskeletal disruption and intracellular glutathione alteration in hepatocytes. Environ. Health Perspec. 2000;108:605-9[Crossref]
• 21. Toivola DM, Eriksson JE, Brautigar DL. Identification of protein phos-phatase 2A as the primary target for microcystin-LR in rat liver homoge-nates. FEBS Lett. 1994;344:175-80.
• 22. McElhiney J, Lawton LA. Detection of the cyanobacterial hepatotoxins microcystins. Toxicol Appl Pharmacol. 2005;203:219-30
• 23. Honkanen RE, Dukelow M, Zwiller J, et al. Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases. Mol Pharmacol. 1991;40:577-83
• 24. McElhiney J, Lawton LA, Leifert C. Investigations into the inhibitory effects of microcystins on plant growth, and the toxicity of plant tissues following exposure. Toxicon. 2001;39:1411-20.[Crossref][PubMed]
• 25. Carmitchael WW. The toksins of cyanobacteria. Sci Am. 1994;270(1):78-86.
• 26. Małkowski P, Pacholczyk P, Łągiewska B, et al. Rak wąrtobowo-komórkowy – epidemiologia i leczenie. Przegl Epidemiol. 2006;60:731-40.
• 27. Falconer IR, Humpage AR. Health risk assessment of cyanobacte-rial (blue-green algal)toxins in drinking water. Int J Res Public Health. 2005;2:43-50.[Crossref]

Identyfikatory

DOI

10.2478/pjph-2014-0035