Low pressure mediated enhancement of nanoparticle and macromolecule loading into porous silicon structures

• Autorzy: Fransisca Leonard , Katherine Margulis , Xuewu Liu , Srimeenakshi Srinivasan , Shlomo Magdassi , Biana Godin
• Języki publikacji: EN

Abstrakty

EN

Ensuring drug loading efficiency and consistency is one of the most critical stages in engineering drug delivery vectors based on porous materials. Here we propose a technique to significantly enhance the effciency of loading by employing simple and widely available methods: applying low pressure with and without centrifugation. Our results point toward the advantages of the proposed method over the passive loading, especially when the difference between the dimensions of loaded materials and the pore diameter is small, an increase of up to 20-fold can be observed. The technique described in this study can be used for efficient and reproducible loading of porous materials with therapeutic molecules, nanoparticles and contrast imaging agents for biomedical applications.

• Czasopismo: Mesoporous Biomaterials
• Rocznik: 2014
• Tom: 1
• Numer: 1

Daty

online

2014-05-29

Twórcy

autor

Fransisca Leonard

• Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA

autor

Katherine Margulis

• Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
• Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA

autor

Xuewu Liu

• Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA

autor

Srimeenakshi Srinivasan

• Houston Methodist Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA

autor

Shlomo Magdassi

• Casali Institute of Applied Chemistry, Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

autor

Biana Godin

• Houston Methodist Research Institute, Department of Nanomedicine, 6670 Bertner Ave, R7-122, Houston, TX 77030. Tel: [phone], Fax: [phone], Email:
  [e-mail]

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Identyfikatory

DOI

10.2478/mesbi-2014-0002