Effects of L-Arginine Supplementation on Blood Pressure Reduction Pre-, Peri-, and Post-Cardiovascular Stimulus in Hypertensive Subjects with Different Angiotensin-Converting-Enzyme Genotypes

• Autorzy: Carlos Ricardo Maneck Malfatti , João Luiz Lang Pavlak , Luiz Augusto da Silva , Thiago Emannuel Medeiros , Katia Cristina Alonso , Roberto Ferreira Artoni , Viviane Nogaroto , Janaína Angela Túrmina , Ana Osiecki , Raul Osiecki
• Języki publikacji: EN

Abstrakty

EN

Purpose. The present study investigated whether L-arginine supplementation reduces blood pressure (BP) in hypertensive subjects with different ACE genotypes. Methods. Eight male hypertensive patients received L-arginine (2 or 4 g/day) or a placebo for a period of 4 days prior an exercise test. Statistical analysis consisted of one-way analysis of variance. Results. L-arginine supplementation induced a statistically significant (p ⋋ 0.05) reduction in systolic BP measured during rest (reductions of 7.8% and 12.3% with 2 and 4 g/day, respectively), exercise (reductions of 11.8% and 10.4% with 2 and 4 g/day, respectively), and recovery (reductions of 11.7% and 10.7% with 2 and 4 g/day, respectively). The observed magnitude of BP reduction suggests an association with ACE polymorphism; a larger effect was seen with the II and DI genotypes compared with the DD genotype (II: 121 mmHg and DI: 133 mmHg vs. DD: 144 mmHg). Conclusions. The results showed that L-arginine supplementation at low doses was efficient in reducing BP and that vasodilator actions that occurred through the secretion of nitric oxide might be ACE genotype dependent.

Słowa kluczowe

EN

exercise; hypertension; nitric oxide; vasodilatation

• Czasopismo: Human Movement
• Rocznik: 2014
• Tom: 15
• Numer: 2
• Strony: 116-119

Daty

otrzymano

2013-04-08

zaakceptowano

2014-04-23

online

2014-08-15

Twórcy

autor

Carlos Ricardo Maneck Malfatti

• Department of Physiotherapy, Midwest State University of Parana Guarapuava, PR, Brazil,

autor

João Luiz Lang Pavlak

• Pharmaceutical Science Postgraduate Program, Midwest State University of Parana, Guarapuava, PR, Brazil

autor

Luiz Augusto da Silva

• Pharmaceutical Science Postgraduate Program, Midwest State University of Parana, Guarapuava, PR, Brazil

autor

Thiago Emannuel Medeiros

• Physical Education Postgraduate Program, State University of Santa Catarina, Florianópolis, SC, Brazil

autor

Katia Cristina Alonso

• Evolutionary Biology Postgraduate Program, State University of Ponta Grossa, Ponta Grossa, PR, Brazil

autor

Roberto Ferreira Artoni

• Evolutionary Biology Postgraduate Program, State University of Ponta Grossa, Ponta Grossa, PR, Brazil

autor

Viviane Nogaroto

• Evolutionary Biology Postgraduate Program, State University of Ponta Grossa, Ponta Grossa, PR, Brazil

autor

Janaína Angela Túrmina

• Pharmaceutical Science Postgraduate Program, Midwest State University of Parana, Guarapuava, PR, Brazil

autor

Ana Osiecki

• Department of Physical Education, Federal University of Paraná, Curitiba, PR, Brazil

autor

Raul Osiecki

• Department of Physical Education, Federal University of Paraná, Curitiba, PR, Brazil

Bibliografia

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Identyfikatory

DOI

10.2478/humo-2014-0012