Synthesis of a series of vicinal diamines with potential biological activity

• Autorzy: Vanya Kurteva , Maria Lyapova
• Języki publikacji: EN

Abstrakty

EN

A broad range of vicinal diamines based on styrene oxide are synthesisedvia mixtures of regioisomeric amino alcohols. The ring opening of the intermediate aziridinium ions by primary amines proceeds with high regioselectivity, leading to the target diamines as single regioisomers for all reaction series. The compounds are of potential biological interest as ligands for cisplatin analogues. Anticancer activity tests of both groups of compounds are in progress.

Słowa kluczowe

EN

Amino alcohols; aziridinium ion; ring opening; vicinal diamines; regioselectivity

• Czasopismo: Open Chemistry
• Rocznik: 2004
• Tom: 2
• Numer: 4
• Strony: 686-695

Daty

wydano

2004-12-01

online

2004-12-01

Twórcy

autor

Vanya Kurteva

• Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl.9, 1113, Sofia, Bulgaria,

autor

Maria Lyapova

• Institute of Organic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl.9, 1113, Sofia, Bulgaria

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Identyfikatory

DOI

10.2478/BF02482731