Profile of adult acute cholinesterase inhibitors substances poisoning – a 30 years analysis

• Autorzy: Eugen N. Gazzi , Victorita Sorodoc , Irina M. Jaba , Catalina Lionte , Cristina Bologa , Catalina E. Lupusoru , Raoul Lupusoru , Laurentiu Sorodoc , Ovidiu Petris
• Języki publikacji: EN

Abstrakty

EN

Objectives: The objective of this study was to assess the pattern and outcome of acute cholinesterase inhibitors substances (CIS) poisoning cases, in a cohort from a regional tertiary care hospital. Methods: cases admitted in the Toxicology Clinic of “Sf. Spiridon” Emergency Clinic Hospital Iasi, Romania between 1983 and 2013 were studied. Results: a total number of 606 patients were included. The reason for exposures was intentional in 70% of cases and the commonest route of poisoning was oral in 92.2%. The highest percent of cases was females (56.4), the age group 20-29 (25.4%) and the majority (66.7%) coming from rural areas, 28.2% being agricultural workers. 36.6% of cases were severe clinical forms. Overall mortality rates were 3.8%, more than half of the death patients (65.2%) had concomitant alcohol intake. It was a significant statistical association between decrease level of serum cholinesterase on admittance and severe forms (p 0.000) and between survival and deaths groups (p 0.000). The pattern of poisoning described by our retrospective study suggests that CIS poisoning are mainly preventable. The main effective goals for prevention are restriction in free accessibility to toxic pesticides, together with sustained efforts in education concerning the life-threatening danger of pesticide poisoning.

Słowa kluczowe

EN

Epidemiology; pesticide; toxicity

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

otrzymano

2014-09-18

zaakceptowano

2015-03-31

online

2015-05-08

Twórcy

autor

Eugen N. Gazzi

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

autor

Victorita Sorodoc

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

autor

Irina M. Jaba

• Pharmacology – Toxicology Department,
  Faculty of Medicine, „Gr. T. Popa” University of Medicine
  and Pharmacy, Iasi, Romania

autor

Catalina Lionte

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

autor

Cristina Bologa

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

autor

Catalina E. Lupusoru

• Pharmacology – Toxicology Department,
  Faculty of Medicine, „Gr. T. Popa” University of Medicine
  and Pharmacy, Iasi, Romania

autor

Raoul Lupusoru

• Physiopathology Department, Faculty of Medicine,
  „Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

autor

Laurentiu Sorodoc

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

autor

Ovidiu Petris

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

Bibliografia

• [1] Kishi M, Ladou J. International pesticide use. Int J OccupEnviron Health 2001; 7: 259-265[Crossref]
• [2] Chen SY, Zhou J, Li ZJ, Wu YQ. A survey of emergency treatmentof pesticides poisoning in comprehensive hospitals. ZhonghuaLao Dong Wei Sheng Zhi Ye Bing Za Zhi 2004; 22: 364-367
• [3] Zhang M, Fang X, Zhou L, Su L, Zheng J, Jin M, Zou H, ChenG. Pesticide poisoning in Zhejiang, China: a retrospectiveanalysis of adult cases registration by occupational diseasesurveillance and reporting systems from 2006 to 2010. BMJOpen 2013;3:e003510. doi:10.1136/bmjopen-2013-003510[WoS][Crossref]
• [4] Eddleston M, Sudarshan K, Senthilkumaran M, Reginald K,Karalliedde L, Senarathna L, de Silva D, Rezvi Sheriff MH,Buckley NA, Gunnell DJ. Patterns of hospital transfer forself-poisoned patients in rural Sri Lanka: implications forestimating the incidence of self-poisoning in the developingworld. Bull World Health Organ 2006; 84: 276-282[Crossref]
• [5] Kora SA, Doddamani GB, Halagali GR, Vijayamahantesh SN,Boke U. Sociodemographic Profile of the OrganophosphorusPoisoning Cases in Southern India. Journal of Clinical andDiagnostic Research 2011; 5(5): 953-956
• [6] Dash SK, Mohanty MK, Patnaik KK, Mohanty S. The sociodemographicprofile of the poisoning cases. J. Ind.Acad. Forensicmed 2005; 3:133-138
• [7] Kim HJ, Cha ES, Ko Y, Kim J, Kim SD, Lee WJ. Pesticidepoisonings in South Korea: Findings from the NationalHospital Discharge Survey 2004–2006. Hum Exp Toxicol 2012;31:751-758[Crossref][WoS]
• [8] Chataut J, Adhikari RK, Sinha NP, Marahatta SB. Pattern oforganophosphorous poisoning: a retrospective communitybased study. Kathmandu Univ Med J 2011; 34(2):31-34
• [9] Gunnell D, Eddleston M, Phillips MR, Konradsen F. The globaldistribution of fatal pesticide self poisoning: systematic review.BMC Public Health 2007; 7:357[WoS][Crossref]
• [10] Klein-Schwartz W, Smith GS. Agricultural and horticulturalchemical poisonings: mortality and morbidity in the UnitedStates. Ann Emerg Med 1997; 29(2): 232-238[Crossref]
• [11] Persson H, Palmborg M, Irestedt B, and Westberg U. Pesticidepoisoning in Sweden: actual situation and changes over a 10year period. Przegl Lek 1997; 54(10): 657-661
• [12] Badakhsh R, Lackovic M, Ratard R. Characteristics of pesticiderelatedhospitalizations, Louisiana, 1998-2007. Public HealthRep 2010; 125(3): 457-467[Crossref]
• [13] Lamminpaa A, Riihimaki V. Pesticide-related incidents treatedin Finnish hospitals: a review of cases registered over a 5-yearperiod. Hum Exp Toxicol 1992; 11(6): 473-479[Crossref]
• [14] van der Hoek W, Konradsen F. Risk factors for acute pesticidepoisoning in Sri Lanka. Trop Med Int Health 2005; 10(6):589-596[Crossref]
• [15] Wesseling C, Castillo L, Elinder CG. Pesticide poisonings inCosta Rica. Scand J Work Environ Health 1993; 19(4): 227-235[Crossref]
• [16] Murali R, Bhalla A, SinghD, Singh S. Acute pesticide poisoning:15 years experience of a large North-West Indian hospital. ClinToxicol (Phila) 2009; 47(1): 35-38[Crossref][WoS]
• [17] Nagami H, Nishigaki Y, Matsushima S, Matsushita T, AsanumaS, Yajima N, Usuda M, Hirosawa M. Hospital-based survey ofpesticide poisoning in Japan, 1998-2002. Int J Occup EnvironHealth 2005; 11(2): 180-184[Crossref]
• [18] Garry VF. Pesticides and children. Toxicol Appl Pharmacol 2004;198(2): 152-163[Crossref]
• [19] Banerjee I, SK Tripathi, Roy AS. Clinico-EpidemiologicalCharacteristics of Patients Presenting with OrganophosphorusPoisoning. N Am J Med Sci. 2012; 4(3): 147-150[Crossref]
• [20] Rehiman S, Lohani SP, Bhattarai MC. Correlation of serumcholinesterase level, clinical score at presentation and severityof organophosphorous poisoning. J Nepal Med Assoc.2008;47:47-52
• [21] Gannur DG, Maka P, Reddy N. Organophosphorus compoundpoisoning in Gulbargaregion - A five year study. Indian JForensic Med Toxicol. 2008
• [22] Sorodoc V, Jaba IM, Lionte C, Mungiu OC, Sorodoc L.Epidemiology of acute drug poisoning in a tertiary center fromIași county, Romania. Hum Exp Toxicol 2011; 30(12):1896-1903[Crossref]
• [23] Eddleston M, Buckley NA, Konradsen F. Identification ofstrategies to prevent death after pesticide self-poisoning usingHaddon matrix. Inj Prev 2006; 12(5):333-337[Crossref]
• [24] Risal A, Sharma PP, Karkib R. Psychiatric Illnesses among thePatients Admitted for Self-poisoning in a Tertiary Care Hospitalof Nepal. Journal of Advances in Internal Medicine 2013;02(01):10-3
• [25] Haw C, Hawton K, Houston K, Townsend E. Psychiatric andpersonality disorders in deliberate self harm patients. Br JPsychiatry 2001; 178:48-54[Crossref]
• [26] Exiara T, Mavrakanas TA, Papazoglou L, Christakidis D, MaltezosE. A prospective study of acute poisonings in a sample of Greekpatients. Cent Eur J Public Health 2009; 17:158-160
• [27] Eddleston M, Eyer P, Worek F, Sheriff M, Buckley NA. Predictingoutcome using butyrylcholinesterase activity in organophosphoruspesticide self poisoning. QJM 2008; 101:467-474[WoS][Crossref]
• [28] Li Y, Tse ML, Gawarammana I, Buckley N, Eddleston M.Systematic review of controlled clinical trials of gastric lavagein acute organophosphorus pesticide poisoning. Clin Toxicol(Phila) 2009; 47:179-192[WoS][Crossref]
• [29] Eddleston M, Haggalla S, Reginald K, Sudarshan K, SenthilkumaranM, Karalliedde L, Ariaratnam A, Sheriff MHR, WarrellDA, Buckley NA. The hazards of gastric lavage for intentionalself-poisoning in a resource poor location. Clinical Toxicology2007; 45:136-143[WoS][Crossref]
• [30] Naderi S, Sud P, Acerra J, Pardo S, D Amore JZ, Ward MF,Mathias M, Miele K, Bose RA, Alagappan K. The Use of GastricLavage in India for Poisoned Patients. J Clin Toxicol 2012; 2:118[Crossref]
• [31] Rhalem R, Achour S, Soulaymani A, Soulaymani R. PesticidePoisoning: Experience of Poisoning Control Centre of Morocco.Clinical Toxicology 2008; 46:391-391
• [32] Lin T, Walter F, Hung D, Tsai J, Hu S, Chang J, Deng J, Chase P,Denninghoff K, Chan H. Epidemiology of organophosphatepesticide poisoning in Taiwan. Clinical Toxicology 2008;46(9):794-801[WoS][Crossref]
• [33] Eddleston M, Gunnell D, von Meyer L, Eyer P. Relationshipbetween blood alcohol concentration on admission andoutcome in dimethoate organophosphorus self-poisoning.British Journal of Clinical Pharmacology 2009; 68:916-919[Crossref]
• [34] Lin TJ, Jiang DD, Chan HM, Hung DZ, Li HP. Prognostic factors oforganophosphate poisoning between the death and survivalgroups. Kaohsiung J Med Sci 2007; 23:176-182[WoS][Crossref]

Identyfikatory

DOI

10.1515/med-2015-0041