Carotid ultrasound for pulmonary arteriovenous malformation screening

• Autorzy: Anita Yanna-Schulze , Günther Schneider , Alexander Maßmann , Stefan Gräber , Urban W. Geisthoff
• Języki publikacji: EN

Abstrakty

EN

Objective: In patients with hereditary hemorrhagic telangiectasia (HHT), pulmonary arteriovenous malformations (PAVMs) can cause serious neurological complications. Our aim was to evaluate the potential of contrast-enhanced Doppler ultrasound (CE-US) of the common carotid artery as a screening test for detection of PAVMs. Methods: A total of 124 consecutive patients with HHT or a positive family history underwent screening for PAVMs with CE-US and thoracic contrast-enhanced magnetic resonance angiography (CE-MRA). CE-US was performed after receiving (D)-galactose microparticulate, and CE-MRA with gadobenate dimeglumine. Twenty-five patients with confirmed PAVMs were referred to conventional pulmonary catheter angiography (PA). Findings on CE-US and CE-MRA were evaluated using contingency tables and McNemar’s test. Results: Using CE-MRA as the reference test, CE-US had a sensitivity of 100%, a specificity of 87%, and a negative predictive value of 100%. In 25 patients who underwent PA, PAVMs that had been diagnosed on CE-US and CE-MRA were confirmed. Of the PAVMs detected by CE-MRA, 24% were not identified on PA. Conclusion: CE-US is a simple, minimally invasive screening method that can easily be performed in different settings. CE-US can predict PAVMs with high probability of success. CE-US may be a simple alternative to transthoracic echocardiography in the assessment of PAVMs in certain HHT-patients.

Słowa kluczowe

EN

Hereditary hemorrhagic telangiectasia; pulmonaryarteriovenous malformation; screening; contrast-enhancedultrasound

• Czasopismo: Open Medicine
• Rocznik: 2014
• Tom: 10
• Numer: 1

Daty

otrzymano

2014-12-19

zaakceptowano

2015-04-04

online

2015-05-11

Twórcy

autor

Anita Yanna-Schulze

• Department of Cardiology,
  Städtisches Krankenhaus Pirmasens gGmbH, Pettenkoferstr.
  22, 66955 Pirmasens, Germany

autor

Günther Schneider

• Medical Faculty of the Saarland University,
  66421 Homburg/Saar, Germany
• Department of Diagnostic and Interventional
  Radiology, Saarland University Hospital, 66421 Homburg/Saar,
  Germany

autor

Alexander Maßmann

• Department of Diagnostic and Interventional
  Radiology, Saarland University Hospital, 66421 Homburg/Saar,
  Germany

autor

Stefan Gräber

• Department of Medical Biometry, Epidemiology and
  Medical Informatics, Saarland University Hospital, 66421 Homburg/
  Saar, Germany

autor

Urban W. Geisthoff

• Department of Otorhinolaryngology, Essen
  University Hospital, 45147 Essen, Germany

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Identyfikatory

DOI

10.1515/med-2015-0040